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    NUCB2 nucleobindin 2 [ Homo sapiens (human) ]

    Gene ID: 4925, updated on 10-Oct-2019

    Summary

    Official Symbol
    NUCB2provided by HGNC
    Official Full Name
    nucleobindin 2provided by HGNC
    Primary source
    HGNC:HGNC:8044
    See related
    Ensembl:ENSG00000070081 MIM:608020
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    NEFA; HEL-S-109
    Summary
    This gene encodes a protein with a suggested role in calcium level maintenance, eating regulation in the hypothalamus, and release of tumor necrosis factor from vascular endothelial cells. This protein binds calcium and has EF-folding domains. [provided by RefSeq, Oct 2011]
    Expression
    Broad expression in bone marrow (RPKM 51.4), salivary gland (RPKM 41.2) and 24 other tissues See more
    Orthologs

    Genomic context

    See NUCB2 in Genome Data Viewer
    Location:
    11p15.1
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    109.20190905 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (17260337..17349980)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (17281884..17371510)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha Neighboring gene ribosomal protein L29 pseudogene 21 Neighboring gene ribosomal protein S2 pseudogene 40 Neighboring gene uncharacterized LOC105376576 Neighboring gene natural killer cell cytotoxicity receptor 3 ligand 1 Neighboring gene uncharacterized LOC107984316

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    NHGRI GWAS Catalog

    Description
    Hundreds of variants clustered in genomic loci and biological pathways affect human height.
    NHGRI GWA Catalog

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • FLJ39156

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    G-protein alpha-subunit binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    calcium ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    negative regulation of appetite IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
     
    cytosol TAS
    Traceable Author Statement
    more info
    PubMed 
    endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
     
    endoplasmic reticulum-Golgi intermediate compartment IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    endoplasmic reticulum-Golgi intermediate compartment IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular exosome HDA PubMed 
    extracellular space HDA PubMed 
    nuclear outer membrane IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane TAS
    Traceable Author Statement
    more info
    PubMed 

    General protein information

    Preferred Names
    nucleobindin-2
    Names
    DNA-binding protein NEFA
    epididymis secretory protein Li 109
    gastric cancer antigen Zg4
    nesfatin 1
    novel DNA binding/EF-hand/leucine zipper protein
    nucleobinding 2
    prepronesfatin

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001330227.2NP_001317156.1  nucleobindin-2 isoform 2 preproprotein

      Status: VALIDATED

      Source sequence(s)
      AC107956, KF455328
      Consensus CDS
      CCDS81556.1
      UniProtKB/TrEMBL
      Q2L696
      Conserved Domains (1) summary
      cl25602
      Location:258369
      DUF3552; Domain of unknown function (DUF3552)
    2. NM_001352661.1NP_001339590.1  nucleobindin-2 isoform 3 preproprotein

      Status: VALIDATED

      Source sequence(s)
      AC107956, KF455328
      Conserved Domains (2) summary
      pfam13499
      Location:248324
      EF-hand_7; EF-hand domain pair
      cl25632
      Location:306399
      type_I_hlyD; type I secretion membrane fusion protein, HlyD family
    3. NM_001352662.1NP_001339591.1  nucleobindin-2 isoform 4 preproprotein

      Status: VALIDATED

      Source sequence(s)
      AC107956, KF455328
      Conserved Domains (1) summary
      cl25602
      Location:259370
      DUF3552; Domain of unknown function (DUF3552)
    4. NM_001352663.1NP_001339592.1  nucleobindin-2 isoform 3 preproprotein

      Status: VALIDATED

      Source sequence(s)
      AC107956, KF455328
      Conserved Domains (2) summary
      pfam13499
      Location:248324
      EF-hand_7; EF-hand domain pair
      cl25632
      Location:306399
      type_I_hlyD; type I secretion membrane fusion protein, HlyD family
    5. NM_001352664.1NP_001339593.1  nucleobindin-2 isoform 1 preproprotein

      Status: VALIDATED

      Source sequence(s)
      AC107956, KF455328
      Consensus CDS
      CCDS41623.1
      Conserved Domains (2) summary
      pfam13499
      Location:247323
      EF-hand_7; EF-hand domain pair
      cl25632
      Location:305398
      type_I_hlyD; type I secretion membrane fusion protein, HlyD family
    6. NM_001352665.1NP_001339594.1  nucleobindin-2 isoform 2 preproprotein

      Status: VALIDATED

      Source sequence(s)
      AC107956, KF455328
      Consensus CDS
      CCDS81556.1
      Conserved Domains (1) summary
      cl25602
      Location:258369
      DUF3552; Domain of unknown function (DUF3552)
    7. NM_001352666.1NP_001339595.1  nucleobindin-2 isoform 2 preproprotein

      Status: VALIDATED

      Source sequence(s)
      AC107956, KF455328
      Consensus CDS
      CCDS81556.1
      Conserved Domains (1) summary
      cl25602
      Location:258369
      DUF3552; Domain of unknown function (DUF3552)
    8. NM_001352667.1NP_001339596.1  nucleobindin-2 isoform 2 preproprotein

      Status: VALIDATED

      Source sequence(s)
      AC107956, KF455328
      Consensus CDS
      CCDS81556.1
      Related
      ENSP00000408702.2, ENST00000458064.6
      Conserved Domains (1) summary
      cl25602
      Location:258369
      DUF3552; Domain of unknown function (DUF3552)
    9. NM_001352668.1NP_001339597.1  nucleobindin-2 isoform 1 preproprotein

      Status: VALIDATED

      Source sequence(s)
      AC107956, KF455328
      Consensus CDS
      CCDS41623.1
      Conserved Domains (2) summary
      pfam13499
      Location:247323
      EF-hand_7; EF-hand domain pair
      cl25632
      Location:305398
      type_I_hlyD; type I secretion membrane fusion protein, HlyD family
    10. NM_001352669.1NP_001339598.1  nucleobindin-2 isoform 1 preproprotein

      Status: VALIDATED

      Source sequence(s)
      AC107956, KF455328
      Consensus CDS
      CCDS41623.1
      Related
      ENSP00000320168.6, ENST00000323688.10
      Conserved Domains (2) summary
      pfam13499
      Location:247323
      EF-hand_7; EF-hand domain pair
      cl25632
      Location:305398
      type_I_hlyD; type I secretion membrane fusion protein, HlyD family
    11. NM_001352670.1NP_001339599.1  nucleobindin-2 isoform 1 preproprotein

      Status: VALIDATED

      Source sequence(s)
      AC107956, KF455328
      Consensus CDS
      CCDS41623.1
      Conserved Domains (2) summary
      pfam13499
      Location:247323
      EF-hand_7; EF-hand domain pair
      cl25632
      Location:305398
      type_I_hlyD; type I secretion membrane fusion protein, HlyD family
    12. NM_001352671.1NP_001339600.1  nucleobindin-2 isoform 2 preproprotein

      Status: VALIDATED

      Source sequence(s)
      AC107956, KF455328
      Consensus CDS
      CCDS81556.1
      Conserved Domains (1) summary
      cl25602
      Location:258369
      DUF3552; Domain of unknown function (DUF3552)
    13. NM_001352672.1NP_001339601.1  nucleobindin-2 isoform 1 preproprotein

      Status: VALIDATED

      Source sequence(s)
      AC107956, KF455328
      Consensus CDS
      CCDS41623.1
      Conserved Domains (2) summary
      pfam13499
      Location:247323
      EF-hand_7; EF-hand domain pair
      cl25632
      Location:305398
      type_I_hlyD; type I secretion membrane fusion protein, HlyD family
    14. NM_005013.4NP_005004.1  nucleobindin-2 isoform 1 preproprotein

      See identical proteins and their annotated locations for NP_005004.1

      Status: VALIDATED

      Source sequence(s)
      AC107956, KF455328
      Consensus CDS
      CCDS41623.1
      UniProtKB/Swiss-Prot
      P80303
      UniProtKB/TrEMBL
      V9HW75
      Related
      ENSP00000436455.1, ENST00000529010.6
      Conserved Domains (2) summary
      pfam13499
      Location:247323
      EF-hand_7; EF-hand domain pair
      cl25632
      Location:305398
      type_I_hlyD; type I secretion membrane fusion protein, HlyD family

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

      Range
      17260337..17349980
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024448537.1XP_024304305.1  nucleobindin-2 isoform X2

      Conserved Domains (2) summary
      pfam13499
      Location:247323
      EF-hand_7; EF-hand domain pair
      cl25632
      Location:305398
      type_I_hlyD; type I secretion membrane fusion protein, HlyD family
    2. XM_024448544.1XP_024304312.1  nucleobindin-2 isoform X2

      Conserved Domains (2) summary
      pfam13499
      Location:247323
      EF-hand_7; EF-hand domain pair
      cl25632
      Location:305398
      type_I_hlyD; type I secretion membrane fusion protein, HlyD family
    3. XM_017017815.1XP_016873304.1  nucleobindin-2 isoform X3

      UniProtKB/Swiss-Prot
      P80303
      UniProtKB/TrEMBL
      V9HW75
      Conserved Domains (2) summary
      pfam13499
      Location:247323
      EF-hand_7; EF-hand domain pair
      cl25632
      Location:305398
      type_I_hlyD; type I secretion membrane fusion protein, HlyD family
    4. XM_024448546.1XP_024304314.1  nucleobindin-2 isoform X2

      Conserved Domains (2) summary
      pfam13499
      Location:247323
      EF-hand_7; EF-hand domain pair
      cl25632
      Location:305398
      type_I_hlyD; type I secretion membrane fusion protein, HlyD family
    5. XM_024448543.1XP_024304311.1  nucleobindin-2 isoform X2

      Conserved Domains (2) summary
      pfam13499
      Location:247323
      EF-hand_7; EF-hand domain pair
      cl25632
      Location:305398
      type_I_hlyD; type I secretion membrane fusion protein, HlyD family
    6. XM_024448527.1XP_024304295.1  nucleobindin-2 isoform X1

      Conserved Domains (2) summary
      pfam13499
      Location:248324
      EF-hand_7; EF-hand domain pair
      cl25632
      Location:306399
      type_I_hlyD; type I secretion membrane fusion protein, HlyD family
    7. XM_024448548.1XP_024304316.1  nucleobindin-2 isoform X4

      Conserved Domains (1) summary
      cl25602
      Location:259370
      DUF3552; Domain of unknown function (DUF3552)
    8. XM_024448551.1XP_024304319.1  nucleobindin-2 isoform X5

      Conserved Domains (1) summary
      cl25602
      Location:258369
      DUF3552; Domain of unknown function (DUF3552)
    9. XM_024448533.1XP_024304301.1  nucleobindin-2 isoform X2

      Conserved Domains (2) summary
      pfam13499
      Location:247323
      EF-hand_7; EF-hand domain pair
      cl25632
      Location:305398
      type_I_hlyD; type I secretion membrane fusion protein, HlyD family
    10. XM_024448528.1XP_024304296.1  nucleobindin-2 isoform X1

      Conserved Domains (2) summary
      pfam13499
      Location:248324
      EF-hand_7; EF-hand domain pair
      cl25632
      Location:306399
      type_I_hlyD; type I secretion membrane fusion protein, HlyD family
    11. XM_024448550.1XP_024304318.1  nucleobindin-2 isoform X5

      Conserved Domains (1) summary
      cl25602
      Location:258369
      DUF3552; Domain of unknown function (DUF3552)
    12. XM_024448532.1XP_024304300.1  nucleobindin-2 isoform X2

      Conserved Domains (2) summary
      pfam13499
      Location:247323
      EF-hand_7; EF-hand domain pair
      cl25632
      Location:305398
      type_I_hlyD; type I secretion membrane fusion protein, HlyD family
    13. XM_017017818.2XP_016873307.1  nucleobindin-2 isoform X3

      UniProtKB/Swiss-Prot
      P80303
      UniProtKB/TrEMBL
      V9HW75
      Related
      ENSP00000481959.1, ENST00000622082.4
      Conserved Domains (2) summary
      pfam13499
      Location:247323
      EF-hand_7; EF-hand domain pair
      cl25632
      Location:305398
      type_I_hlyD; type I secretion membrane fusion protein, HlyD family
    14. XM_024448535.1XP_024304303.1  nucleobindin-2 isoform X2

      Conserved Domains (2) summary
      pfam13499
      Location:247323
      EF-hand_7; EF-hand domain pair
      cl25632
      Location:305398
      type_I_hlyD; type I secretion membrane fusion protein, HlyD family
    15. XM_017017826.1XP_016873315.1  nucleobindin-2 isoform X7

      UniProtKB/TrEMBL
      Q2L696
      Conserved Domains (1) summary
      cl25602
      Location:258369
      DUF3552; Domain of unknown function (DUF3552)
    16. XM_024448554.1XP_024304322.1  nucleobindin-2 isoform X6

      Conserved Domains (1) summary
      cl25602
      Location:259370
      DUF3552; Domain of unknown function (DUF3552)
    17. XM_024448553.1XP_024304321.1  nucleobindin-2 isoform X5

      Conserved Domains (1) summary
      cl25602
      Location:258369
      DUF3552; Domain of unknown function (DUF3552)
    18. XM_024448549.1XP_024304317.1  nucleobindin-2 isoform X5

      Conserved Domains (1) summary
      cl25602
      Location:258369
      DUF3552; Domain of unknown function (DUF3552)
    19. XM_024448531.1XP_024304299.1  nucleobindin-2 isoform X2

      Conserved Domains (2) summary
      pfam13499
      Location:247323
      EF-hand_7; EF-hand domain pair
      cl25632
      Location:305398
      type_I_hlyD; type I secretion membrane fusion protein, HlyD family
    20. XM_024448530.1XP_024304298.1  nucleobindin-2 isoform X1

      Conserved Domains (2) summary
      pfam13499
      Location:248324
      EF-hand_7; EF-hand domain pair
      cl25632
      Location:306399
      type_I_hlyD; type I secretion membrane fusion protein, HlyD family
    21. XM_024448547.1XP_024304315.1  nucleobindin-2 isoform X2

      Conserved Domains (2) summary
      pfam13499
      Location:247323
      EF-hand_7; EF-hand domain pair
      cl25632
      Location:305398
      type_I_hlyD; type I secretion membrane fusion protein, HlyD family
    22. XM_024448540.1XP_024304308.1  nucleobindin-2 isoform X2

      Conserved Domains (2) summary
      pfam13499
      Location:247323
      EF-hand_7; EF-hand domain pair
      cl25632
      Location:305398
      type_I_hlyD; type I secretion membrane fusion protein, HlyD family
    23. XM_017017828.1XP_016873317.1  nucleobindin-2 isoform X7

      UniProtKB/TrEMBL
      Q2L696
      Conserved Domains (1) summary
      cl25602
      Location:258369
      DUF3552; Domain of unknown function (DUF3552)
    24. XM_017017814.1XP_016873303.1  nucleobindin-2 isoform X3

      UniProtKB/Swiss-Prot
      P80303
      UniProtKB/TrEMBL
      V9HW75
      Conserved Domains (2) summary
      pfam13499
      Location:247323
      EF-hand_7; EF-hand domain pair
      cl25632
      Location:305398
      type_I_hlyD; type I secretion membrane fusion protein, HlyD family
    25. XM_024448542.1XP_024304310.1  nucleobindin-2 isoform X2

      Conserved Domains (2) summary
      pfam13499
      Location:247323
      EF-hand_7; EF-hand domain pair
      cl25632
      Location:305398
      type_I_hlyD; type I secretion membrane fusion protein, HlyD family
    26. XM_017017812.2XP_016873301.1  nucleobindin-2 isoform X3

      UniProtKB/Swiss-Prot
      P80303
      UniProtKB/TrEMBL
      V9HW75
      Conserved Domains (2) summary
      pfam13499
      Location:247323
      EF-hand_7; EF-hand domain pair
      cl25632
      Location:305398
      type_I_hlyD; type I secretion membrane fusion protein, HlyD family
    27. XM_024448538.1XP_024304306.1  nucleobindin-2 isoform X2

      Conserved Domains (2) summary
      pfam13499
      Location:247323
      EF-hand_7; EF-hand domain pair
      cl25632
      Location:305398
      type_I_hlyD; type I secretion membrane fusion protein, HlyD family
    28. XM_024448541.1XP_024304309.1  nucleobindin-2 isoform X2

      Conserved Domains (2) summary
      pfam13499
      Location:247323
      EF-hand_7; EF-hand domain pair
      cl25632
      Location:305398
      type_I_hlyD; type I secretion membrane fusion protein, HlyD family
    29. XM_024448552.1XP_024304320.1  nucleobindin-2 isoform X5

      Conserved Domains (1) summary
      cl25602
      Location:258369
      DUF3552; Domain of unknown function (DUF3552)
    30. XM_024448539.1XP_024304307.1  nucleobindin-2 isoform X2

      Conserved Domains (2) summary
      pfam13499
      Location:247323
      EF-hand_7; EF-hand domain pair
      cl25632
      Location:305398
      type_I_hlyD; type I secretion membrane fusion protein, HlyD family
    31. XM_017017813.1XP_016873302.1  nucleobindin-2 isoform X3

      UniProtKB/Swiss-Prot
      P80303
      UniProtKB/TrEMBL
      V9HW75
      Conserved Domains (2) summary
      pfam13499
      Location:247323
      EF-hand_7; EF-hand domain pair
      cl25632
      Location:305398
      type_I_hlyD; type I secretion membrane fusion protein, HlyD family
    32. XM_024448529.1XP_024304297.1  nucleobindin-2 isoform X1

      Conserved Domains (2) summary
      pfam13499
      Location:248324
      EF-hand_7; EF-hand domain pair
      cl25632
      Location:306399
      type_I_hlyD; type I secretion membrane fusion protein, HlyD family
    33. XM_024448536.1XP_024304304.1  nucleobindin-2 isoform X2

      Conserved Domains (2) summary
      pfam13499
      Location:247323
      EF-hand_7; EF-hand domain pair
      cl25632
      Location:305398
      type_I_hlyD; type I secretion membrane fusion protein, HlyD family
    34. XM_024448534.1XP_024304302.1  nucleobindin-2 isoform X2

      Conserved Domains (2) summary
      pfam13499
      Location:247323
      EF-hand_7; EF-hand domain pair
      cl25632
      Location:305398
      type_I_hlyD; type I secretion membrane fusion protein, HlyD family
    35. XM_017017817.1XP_016873306.1  nucleobindin-2 isoform X3

      UniProtKB/Swiss-Prot
      P80303
      UniProtKB/TrEMBL
      V9HW75
      Conserved Domains (2) summary
      pfam13499
      Location:247323
      EF-hand_7; EF-hand domain pair
      cl25632
      Location:305398
      type_I_hlyD; type I secretion membrane fusion protein, HlyD family
    36. XM_024448545.1XP_024304313.1  nucleobindin-2 isoform X2

      Conserved Domains (2) summary
      pfam13499
      Location:247323
      EF-hand_7; EF-hand domain pair
      cl25632
      Location:305398
      type_I_hlyD; type I secretion membrane fusion protein, HlyD family

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NR_132751.1: Suppressed sequence

      Description
      NR_132751.1: This RefSeq was removed because currently there is insufficient support for the transcript.
    Support Center