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    NQO2 N-ribosyldihydronicotinamide:quinone reductase 2 [ Homo sapiens (human) ]

    Gene ID: 4835, updated on 15-Jun-2019

    Summary

    Official Symbol
    NQO2provided by HGNC
    Official Full Name
    N-ribosyldihydronicotinamide:quinone reductase 2provided by HGNC
    Primary source
    HGNC:HGNC:7856
    See related
    Ensembl:ENSG00000124588 MIM:160998
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    QR2; DHQV; DIA6; NMOR2
    Summary
    This gene encodes a member of the thioredoxin family of enzymes. It is a cytosolic and ubiquitously expressed flavoprotein that catalyzes the two-electron reduction of quinone substrates and uses dihydronicotinamide riboside as a reducing coenzyme. Mutations in this gene have been associated with neurodegenerative diseases and several cancers. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]
    Expression
    Broad expression in kidney (RPKM 43.3), fat (RPKM 18.6) and 24 other tissues See more
    Orthologs

    Genomic context

    See NQO2 in Genome Data Viewer
    Location:
    6p25.2
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 6 NC_000006.12 (2999816..3019876)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (3000067..3019997)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene SERPINB6-LINC01011 intergenic CAGE-defined mid-level expression enhancer Neighboring gene uncharacterized LOC105374888 Neighboring gene long intergenic non-protein coding RNA 1011 Neighboring gene HIV-1 Tat specific factor 1 pseudogene 2 Neighboring gene uncharacterized LOC101927759 Neighboring gene family with sequence similarity 136 member B, pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    • Biological oxidations, organism-specific biosystem (from REACTOME)
      Biological oxidations, organism-specific biosystemAll organisms are constantly exposed to foreign chemicals every day. These can be man-made (drugs, industrial chemicals) or natural (alkaloids, toxins from plants and animals). Uptake is usually via ...
    • Metabolism, organism-specific biosystem (from REACTOME)
      Metabolism, organism-specific biosystemMetabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as th...
    • Phase 1 - Functionalization of compounds, organism-specific biosystem (from REACTOME)
      Phase 1 - Functionalization of compounds, organism-specific biosystemPhase 1 of metabolism is concerned with functionalization, that is the introduction or exposure of functional groups on the chemical structure of a compound. This provides a 'handle' for phase 2 conj...
    • Photodynamic therapy-induced NFE2L2 (NRF2) survival signaling, organism-specific biosystem (from WikiPathways)
      Photodynamic therapy-induced NFE2L2 (NRF2) survival signaling, organism-specific biosystemPhotodynamic therapy may induce an antioxidant response mediated by NFE2L2.

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • FLJ39868

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    FAD binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    NAD(P)H dehydrogenase (quinone) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    chloride ion binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    dihydronicotinamide riboside quinone reductase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    electron transfer activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    electron transfer activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    melatonin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    oxidoreductase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    oxidoreductase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    oxidoreductase activity, acting on other nitrogenous compounds as donors IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein homodimerization activity IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    resveratrol binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    zinc ion binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    electron transport chain IEA
    Inferred from Electronic Annotation
    more info
     
    memory IEA
    Inferred from Electronic Annotation
    more info
     
    oxidation-reduction process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of ERK1 and ERK2 cascade IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of neuron apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of reactive oxygen species metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of vascular smooth muscle cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    xenobiotic metabolic process TAS
    Traceable Author Statement
    more info
     
    Component Evidence Code Pubs
    cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol TAS
    Traceable Author Statement
    more info
     
    extracellular exosome HDA PubMed 
    nucleoplasm IDA
    Inferred from Direct Assay
    more info
     

    General protein information

    Preferred Names
    ribosyldihydronicotinamide dehydrogenase [quinone]
    Names
    NAD(P)H dehydrogenase, quinone 2
    NAD(P)H menadione oxidoreductase-1, dioxin-inducible-2
    NAD(P)H quinone dehydrogenase 2
    NRH:quinone oxidoreductase 2
    quinone reductase 2
    ribosyldihydronicotinamide dehydrogenase
    NP_000895.2
    NP_001277150.1
    NP_001277151.1
    NP_001305869.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_034013.1 RefSeqGene

      Range
      5001..25061
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_000904.5NP_000895.2  ribosyldihydronicotinamide dehydrogenase [quinone] isoform 1

      See identical proteins and their annotated locations for NP_000895.2

      Status: REVIEWED

      Source sequence(s)
      AL133351
      Consensus CDS
      CCDS4481.1
      UniProtKB/Swiss-Prot
      P16083
      UniProtKB/TrEMBL
      B3KPX6
      Related
      ENSP00000369822.4, ENST00000380455.9
      Conserved Domains (1) summary
      pfam02525
      Location:5212
      Flavodoxin_2; Flavodoxin-like fold
    2. NM_001290221.1NP_001277150.1  ribosyldihydronicotinamide dehydrogenase [quinone] isoform 1

      See identical proteins and their annotated locations for NP_001277150.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1). Variants 1, 3, and 4 encode the same protein (isoform 1).
      Source sequence(s)
      AK056981, AK311746, AL133351, CD014013, J02888
      Consensus CDS
      CCDS4481.1
      UniProtKB/Swiss-Prot
      P16083
      UniProtKB/TrEMBL
      B3KPX6
      Related
      ENSP00000337773.2, ENST00000338130.6
      Conserved Domains (1) summary
      pfam02525
      Location:5212
      Flavodoxin_2; Flavodoxin-like fold
    3. NM_001290222.1NP_001277151.1  ribosyldihydronicotinamide dehydrogenase [quinone] isoform 2

      See identical proteins and their annotated locations for NP_001277151.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks three exons in the 5' UTR and lacks an alternate in-frame exon in the coding region compared to variant 1. The encoded protein (isoform 2) is shorter, compared to isoform 1.
      Source sequence(s)
      AL133351, BI670476, CD014013
      Consensus CDS
      CCDS75388.1
      UniProtKB/TrEMBL
      Q5TD07
      Related
      ENSP00000369821.4, ENST00000380454.8
      Conserved Domains (1) summary
      pfam02525
      Location:5174
      Flavodoxin_2; Flavodoxin-like fold
    4. NM_001318940.1NP_001305869.1  ribosyldihydronicotinamide dehydrogenase [quinone] isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1, 3, and 4 encode the same protein (isoform 1).
      Source sequence(s)
      AK056981, AL133351, BI333292, CD014013
      Consensus CDS
      CCDS4481.1
      UniProtKB/Swiss-Prot
      P16083
      UniProtKB/TrEMBL
      B3KPX6
      Related
      ENSP00000369795.1, ENST00000380430.5
      Conserved Domains (1) summary
      pfam02525
      Location:5212
      Flavodoxin_2; Flavodoxin-like fold

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

      Range
      2999816..3022746
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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