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    NME2 NME/NM23 nucleoside diphosphate kinase 2 [ Homo sapiens (human) ]

    Gene ID: 4831, updated on 17-Jun-2019

    Summary

    Official Symbol
    NME2provided by HGNC
    Official Full Name
    NME/NM23 nucleoside diphosphate kinase 2provided by HGNC
    Primary source
    HGNC:HGNC:7850
    See related
    Ensembl:ENSG00000243678 MIM:156491
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PUF; NDKB; NDPKB; NM23B; NDPK-B; NM23-H2
    Summary
    Nucleoside diphosphate kinase (NDK) exists as a hexamer composed of 'A' (encoded by NME1) and 'B' (encoded by this gene) isoforms. Multiple alternatively spliced transcript variants have been found for this gene. Read-through transcription from the neighboring upstream gene (NME1) generates naturally-occurring transcripts (NME1-NME2) that encode a fusion protein comprised of sequence sharing identity with each individual gene product. [provided by RefSeq, Nov 2010]
    Expression
    Ubiquitous expression in colon (RPKM 115.3), fat (RPKM 91.9) and 25 other tissues See more
    Orthologs

    Genomic context

    See NME2 in Genome Data Viewer
    Location:
    17q21.33
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    109.20190607 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (51165536..51171744)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (49242796..49249105)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene sperm associated antigen 9 Neighboring gene NME1-NME2 readthrough Neighboring gene NME/NM23 nucleoside diphosphate kinase 1 Neighboring gene mbt domain containing 1 Neighboring gene UTP18 small subunit processome component

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Phenotypes

    NHGRI GWAS Catalog

    Description
    Hundreds of variants clustered in genomic loci and biological pathways affect human height.
    NHGRI GWA Catalog

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat HIV-1 Tat upregulates the expression of NME/NM23 nucleoside diphosphate kinase 2 (NME2) in human primary T cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC2212, MGC111212

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    G-quadruplex DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    GDP binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enzyme binding IEA
    Inferred from Electronic Annotation
    more info
     
    fatty acid binding IEA
    Inferred from Electronic Annotation
    more info
     
    intermediate filament binding IEA
    Inferred from Electronic Annotation
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    nucleoside diphosphate kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleoside diphosphate kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein histidine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    transcription coactivator activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    CTP biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    GTP biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    UTP biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    adenylate cyclase-activating G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    cell adhesion TAS
    Traceable Author Statement
    more info
    PubMed 
    cellular response to fatty acid IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to glucose stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to oxidative stress IEA
    Inferred from Electronic Annotation
    more info
     
    integrin-mediated signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of myeloid leukocyte differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    neutrophil degranulation TAS
    Traceable Author Statement
    more info
     
    nucleobase-containing small molecule interconversion TAS
    Traceable Author Statement
    more info
     
    nucleoside diphosphate phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleoside triphosphate biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    peptidyl-histidine phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of epithelial cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of keratinocyte differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of neuron projection development IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of transcription, DNA-templated IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of transcription, DNA-templated IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein autophosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    protein complex oligomerization IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of epidermis development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to growth hormone IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cell periphery IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol TAS
    Traceable Author Statement
    more info
     
    extracellular exosome HDA PubMed 
    extracellular region TAS
    Traceable Author Statement
    more info
     
    ficolin-1-rich granule lumen TAS
    Traceable Author Statement
    more info
     
    NOT focal adhesion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    intermediate filament IEA
    Inferred from Electronic Annotation
    more info
     
    lamellipodium IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mitochondrial membrane IEA
    Inferred from Electronic Annotation
    more info
     
    nucleus HDA PubMed 
    perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    ruffle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    secretory granule lumen TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    nucleoside diphosphate kinase B
    Names
    HEL-S-155an
    NDP kinase B
    c-myc purine-binding transcription factor PUF
    c-myc transcription factor
    epididymis secretory sperm binding protein Li 155an
    histidine protein kinase NDKB
    non-metastatic cells 2, protein (NM23) expressed in
    non-metastatic cells 2, protein (NM23B) expressed in
    nucleotide diphosphate kinase B
    NP_001018147.1
    NP_001018148.1
    NP_001018149.1
    NP_001185611.1
    NP_002503.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001018137.3NP_001018147.1  nucleoside diphosphate kinase B isoform a

      See identical proteins and their annotated locations for NP_001018147.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1-4 encode the same isoform (a).
      Source sequence(s)
      CA307456, CK023920
      Consensus CDS
      CCDS11580.1
      UniProtKB/Swiss-Prot
      P22392
      UniProtKB/TrEMBL
      Q6FHN3
      Related
      ENSP00000426976.2, ENST00000514264.6
      Conserved Domains (1) summary
      PTZ00093
      Location:3151
      PTZ00093; nucleoside diphosphate kinase, cytosolic; Provisional
    2. NM_001018138.1NP_001018148.1  nucleoside diphosphate kinase B isoform a

      See identical proteins and their annotated locations for NP_001018148.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1-4 encode the same isoform (a).
      Source sequence(s)
      BC002476, BF058708
      Consensus CDS
      CCDS11580.1
      UniProtKB/Swiss-Prot
      P22392
      UniProtKB/TrEMBL
      Q6FHN3
      Related
      ENSP00000376886.1, ENST00000393190.4
      Conserved Domains (1) summary
      PTZ00093
      Location:3151
      PTZ00093; nucleoside diphosphate kinase, cytosolic; Provisional
    3. NM_001018139.2NP_001018149.1  nucleoside diphosphate kinase B isoform a

      See identical proteins and their annotated locations for NP_001018149.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR, compared to variant 1. Variants 1-4 encode the same isoform (a).
      Source sequence(s)
      BM556410
      Consensus CDS
      CCDS11580.1
      UniProtKB/Swiss-Prot
      P22392
      UniProtKB/TrEMBL
      Q6FHN3
      Related
      ENSP00000426901.1, ENST00000503064.5
      Conserved Domains (1) summary
      PTZ00093
      Location:3151
      PTZ00093; nucleoside diphosphate kinase, cytosolic; Provisional
    4. NM_001198682.2NP_001185611.1  nucleoside diphosphate kinase B isoform b

      See identical proteins and their annotated locations for NP_001185611.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) lacks an alternate exon that results in a frameshift in the 3' coding region, compared to variant 1. The encoded isoform (b) has a distinct and shorter C-terminus, compared to isoform a.
      Source sequence(s)
      CB242387, CN267160, DB454073
      Consensus CDS
      CCDS74107.1
      UniProtKB/TrEMBL
      F6XY72
      Related
      ENSP00000376880.4, ENST00000393183.7
      Conserved Domains (2) summary
      cl00335
      Location:576
      NDPk; Nucleoside diphosphate kinases (NDP kinases, NDPks): NDP kinases, responsible for the synthesis of nucleoside triphosphates (NTPs), are involved in numerous regulatory processes associated with proliferation, development, and differentiation. They are ...
      pfam00334
      Location:577
      NDK; Nucleoside diphosphate kinase
    5. NM_002512.4NP_002503.1  nucleoside diphosphate kinase B isoform a

      See identical proteins and their annotated locations for NP_002503.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (a). Variants 1-4 encode the same isoform.
      Source sequence(s)
      BC095458, BF034471, DB454073
      Consensus CDS
      CCDS11580.1
      UniProtKB/Swiss-Prot
      P22392
      UniProtKB/TrEMBL
      Q6FHN3
      Related
      ENSP00000421064.1, ENST00000512737.5
      Conserved Domains (1) summary
      PTZ00093
      Location:3151
      PTZ00093; nucleoside diphosphate kinase, cytosolic; Provisional

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

      Range
      51165536..51171744
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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