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    NFKB1 nuclear factor kappa B subunit 1 [ Homo sapiens (human) ]

    Gene ID: 4790, updated on 21-Jan-2020

    Summary

    Official Symbol
    NFKB1provided by HGNC
    Official Full Name
    nuclear factor kappa B subunit 1provided by HGNC
    Primary source
    HGNC:HGNC:7794
    See related
    Ensembl:ENSG00000109320 MIM:164011
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    p50; KBF1; p105; EBP-1; NF-kB; CVID12; NF-kB1; NFKB-p50; NFkappaB; NF-kappaB; NFKB-p105; NF-kappa-B1
    Summary
    This gene encodes a 105 kD protein which can undergo cotranslational processing by the 26S proteasome to produce a 50 kD protein. The 105 kD protein is a Rel protein-specific transcription inhibitor and the 50 kD protein is a DNA binding subunit of the NF-kappa-B (NFKB) protein complex. NFKB is a transcription regulator that is activated by various intra- and extra-cellular stimuli such as cytokines, oxidant-free radicals, ultraviolet irradiation, and bacterial or viral products. Activated NFKB translocates into the nucleus and stimulates the expression of genes involved in a wide variety of biological functions. Inappropriate activation of NFKB has been associated with a number of inflammatory diseases while persistent inhibition of NFKB leads to inappropriate immune cell development or delayed cell growth. Alternative splicing results in multiple transcript variants encoding different isoforms, at least one of which is proteolytically processed. [provided by RefSeq, Feb 2016]
    Expression
    Ubiquitous expression in bone marrow (RPKM 27.7), appendix (RPKM 20.3) and 25 other tissues See more
    Orthologs

    Genomic context

    See NFKB1 in Genome Data Viewer
    Location:
    4q24
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    109.20191205 current GRCh38.p13 (GCF_000001405.39) 4 NC_000004.12 (102501266..102617302)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (103422486..103538459)

    Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene RNA, 7SL, cytoplasmic 728, pseudogene Neighboring gene uncharacterized LOC105377621 Neighboring gene zinc finger protein 705A pseudogene Neighboring gene uncharacterized LOC105377347 Neighboring gene mannosidase beta Neighboring gene ribosomal protein L21 pseudogene 49 Neighboring gene leucine rich repeat containing 37 member A15, pseudogene Neighboring gene keratin 8 pseudogene 46

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    Immunodeficiency, common variable, 12
    MedGen: C4225277 OMIM: 616576 GeneReviews: Not available
    Compare labs

    NHGRI GWAS Catalog

    Description
    Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis.
    NHGRI GWA Catalog
    Genome-wide association study identifies 12 new susceptibility loci for primary biliary cirrhosis.
    NHGRI GWA Catalog
    Genome-wide association study identifies TNFSF15 and POU2AF1 as susceptibility loci for primary biliary cirrhosis in the Japanese population.
    NHGRI GWA Catalog
    Genome-wide association study of treatment refractory schizophrenia in Han Chinese.
    NHGRI GWA Catalog
    Genome-wide contribution of genotype by environment interaction to variation of diabetes-related traits.
    NHGRI GWA Catalog
    Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
    NHGRI GWA Catalog

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    Monocyte derived dendritic cells from HIV-infected clinical samples downregulate NFKB1 (NK-kB) expression PubMed
    Knockdown of nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (NFKB1; p50/p105) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed
    Knockdown of nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (NFKB1; p50/p105) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

    Protein interactions

    Protein Gene Interaction Pubs
    Asp asp Analysis of point mutations in the USF1 and NF-kappaB sites in the cis-acting elements of ASP promoter region shows that USF1 and NF-kappaB are required for ASP activity PubMed
    Envelope surface glycoprotein gp120 env The binding of soluble HIV-1 gp120 to TLR2 or TLR4 results in upregulation of the TNF-alpha and IL-8 production through NF-kappaB activation PubMed
    env HIV-1 gp120 and methamphetamine synergistically induce release of IL-6 through the NF-kappaB pathway in astrocytes PubMed
    env HIV-1 gp120-mediated increases in IL-8 production in astrocytes are mediated through the NF-KapaB pathway PubMed
    env HIV-1 gp120 induces a time-dependent IL-6 upregulation by translocating NF-kappaB1 from cytoplasm to nucleus in human astrocyte cells PubMed
    env HIV-1 gp120-mediated downregulation of P-gp is attenuated by SN50 (a nuclear factor-KappaB [NF-KappaB] inhibitor), suggesting involvement of NF-KappaB signaling in P-gp regulation in primary cultures of human fetal astrocytes PubMed
    env HIV-1 gp120 activates NF-kappaB by inducing phosphorylation of IkappaBalpha in human astrocyte cells PubMed
    env HIV-1 gp120-mediated upregulation of CCL5 expression requires the NF-kappaB pathway in astrocytes PubMed
    env Inhibition of NRF2 by siRNA results in increased NOX2, NFkappaB (p65/p50), TNF-alpha, and MMP-9 proteins in astrocytes exposed to HIV-1 gp120 PubMed
    env Increased neurotoxicity mediated by cocaine and gp120 involves signaling pathways including c-jun N-terminal kinase (JNK), p38, extracellular signal-regulated kinase (ERK)/mitogen-activated protein kinases (MAPK), and nuclear factor (NF)-kappaB PubMed
    env PC-PLC is an upstream regulator of HIV-1 gp120-mediated NF-kappaB activation in human monocyte-derived macrophages PubMed
    env NF-kappaB and JNK signaling are involved in gp120-induced multidrug resistance protein 1 (Mrp1) regulation during an HIV-1 associated inflammatory response PubMed
    env Treatment of human hepatic stellate cells with gp120 significantly increases secretion and gene expression of CCL2, metalloprotease-1 and interleukin-6. Gp120 also induces activation of Akt, NF-kappaB, and p38(MAPK) PubMed
    env HIV-1 gp120 induces NF-kappaB activation and increases p21(cip1/waf1) and p27(kip1) protein levels in human mesangial cells PubMed
    env The mRNA expression levels for alpha-tubulin, TRADD, IFN-gamma R2, GAS1, MADD, NF-kappaB, I-kappa B, 14-3-3 protein, APaf1, PARP, IGF-1 receptor, RB1, Rb2/p130, ARC, and caspase 6 are upregulated in human neuronal cells after treatment with HIV-1 gp120 PubMed
    env HIV-1 gp120/CD4 interaction-induced NF-kappaB activation stimulates the hyperphosphorylation of IkappaB-alpha by IkappaB kinases (IKKs) PubMed
    env HIV-1 envelope protein gp120 is able to induce COX-2 mRNA and protein in human neuroblastoma cell lines that express CXCR4 and CCR5 but not CD4; gp120 induces COX-2 promoter transcription through NF-kappaB and activating protein-1 (AP-1) sites PubMed
    env CD4-p56Lck interaction is required for HIV-1 gp120-induced nuclear translocation of NF-kappaB in HeLa cells PubMed
    env The protein tyrosine kinase p56lck plays an active role in transmitting an HIV-1 gp120-mediated signal that increases the oxidative state of cells and as a consequence amplifies TNF-mediated NF-kappa B DNA binding PubMed
    env In CD4-positive Jurkat cells, gp120 enhances TNF-induced NF-kappa B activation PubMed
    env Binding of heat-inactivated HIV-1 (iHIV-1) or HIV-1 gp120 to infected resting PBMCs is sufficient to activate NF-kappa B and AP-1, to induce cell surface expression of CD25, and to commit cells to produce virus PubMed
    env HIV-1 gp120 and anti-CD4 antibodies induce a specific, significant decrease in the binding activity of NF-AT, NF-kappa B and AP-1, which leads to an inhibition of IL-2 production and cell proliferation PubMed
    Envelope transmembrane glycoprotein gp41 env HIV-1 Env gp41 activates NK-kB (NFKB1) in human brain microvascular endothelial cells PubMed
    env The HIV-1 gp41 cytoplasmic domain-induced NFkappaB activation requires TAK1, RelA, and NEMO proteins PubMed
    env The cytoplasmic domain (residues 704-773) of HIV-1 gp41 induces NFkappaB activation. Deletion of a 12 amino-acid sequence (762CLFSYHRLRDLL) in gp41 leads to a dramatic loss of the NFkappaB activation and tyrosine 766 is particularly important PubMed
    Nef nef HIV-1 Nef modulates NFKB1 activation PubMed
    nef The (PxxP) regions that interact with SH3 domain-containing cellular kinases as well as two acidic C-terminal residues (E154/E155) are critical for Nef-mediated enhancement of NF-kappaB activity PubMed
    nef HIV-1 and SIVcpz Nef proteins enhance TNF-alpha, IKK-beta, and RelA/p65-induced NF-kappaB activation in 293T cells PubMed
    nef HIV-1 Nef activates nuclear transcription factor NF-kappaB in human monocyte/macrophages, promonoctyes, and dendritic cells, and to a lesser extent in immature dendritic cells PubMed
    nef Knockdown of the p50 and p65 subunits of NF-kappaB by siRNA shows significant reduction of CCL5 levels, suggesting that NF-kappaB is involved in Nef-mediated upregulation of CCL5 PubMed
    nef Stimulation of T cells by mitogens or antibodies to the T-cell receptor (TCR)-CD3 complex results in the downregulation of transcriptional factors NF-kappa B and AP-1 in cells expressing HIV-1 Nef PubMed
    nef The interaction of HIV-1 Nef with TRAF2, TRAF5, and TRAF6 proteins activates NF-kappaB, leading to the degradation of IkappaB-alpha and the increased phosphorylation of IKK-alpha and IKK-beta in monocyte-derived macrophages PubMed
    nef HIV-1 Nef upregulates TLR2 expression via NF-kappaB activation in THP-1 cells PubMed
    nef Both the myristoylation site and the acidic cluster in HIV-1 Nef are required for the activation of NF-kappaB, which induces upregulation of TNFalpha and IL6 expression PubMed
    nef HIV-1 Nef immunocomplexes analyzed by mass spectrometry reveal that NFKB-p105 is a Nef-binding protein in Jurkat cells PubMed
    nef Nef-mediated activation of NF-kappaB in macrophages induces secretion of the acute-phase protein ferritin, which is necessary and sufficient for Nef-dependent B cell changes PubMed
    nef HIV-1 Nef suppresses immunoglobulin class-switch DNA recombination by inducing IkappaBalpha and SOCS proteins, which block CD154, IL-4 and IL-10 cytokine signaling via NF-kappaB and STAT transcription factors PubMed
    nef HIV-1 Nef inhibits the induction of HIV-1- and interleukin 2-directed gene expression, and the effect on HIV-1 transcription depends on an intact NF-kappa B-binding site PubMed
    nef HIV-1 Nef expression in Drosophila inhibits NF-kappa-B activation PubMed
    nef HIV-1 Nef inhibits the induction of NF-kappa B DNA-binding activity by T-cell mitogens, however Nef does not affect the DNA-binding activity of other transcription factors implicated in HIV-1 regulation, including SP-1, USF, URS, and NF-AT PubMed
    Tat tat HIV-1 Tat decreases NFKB1 (NF-kB) activation in Leishmania-infected macrophages PubMed
    tat HIV-1 Tat activates NFkappaB, causing the induction of CD95 ligand, CD69, iNOS, MCP-1, IL-2, IL-6, IL-8, IL-10, TNF-alpha, VCAM-1, ICAM-1, E-selectin, and MMP-9, as well as monocyte adhesion, cellular activation and angiogenesis PubMed
    tat Human microglia cells treated with HIV-1 clade C Tat show more significant upregulation of IL-6 and TNF-alpha, and higher NF-kappaB activation as compared to clade B Tat-treated cells PubMed
    tat HIV-1 Tat upregulates the expression of platelet-derived growth factor subunit B homodimer through activation of the PDGFR-B/MEK/NF-kappaB pathway in human brain microvascular pericytes PubMed
    tat HIV-1 Tat-mediated transcriptional activation of the HIV-1 LTR promoter requires NFkappaB binding sites in the promoter and involves the activation of NFkappaB by Tat PubMed
    tat HIV-1 Tat-mediated upregulation of CCL5 involves JAK2/3, AKT2/3, p38delta, NF-kappaB (p65/p50), C/EBP alpha/gamma, and AP-1 proteins PubMed
    tat HIV-1 Tat enhances the NFkappaB activity by inhibiting IkappaB-alpha binding to p65 RelA PubMed
    tat Exogenous Nef and TNF-alpha synergistically activate NF-kappaB and AP-1 resulting in enhancing HIV-1 Tat transactivation of the LTR and viral replication in both chronically infected promonocytic cells and acutely infected primary macrophages PubMed
    tat HIV-1 Tat recruits P/CAF to the integrated HIV-1 LTR promoter causing the acetylation of histones, which in turn leads to the recruitment the p65 subunit of NFkappaB to the promoter PubMed
    tat HIV-1 Tat induces the acetylation of the NFkappaB p50 subunit as well as the p50/p65 complex by p300, causing an increase in NFkappaB DNA binding activity and in the rate of transcription PubMed
    tat Extracellular HIV-1 Tat upregulates the expression of human beta-defensin 2 (hBD-2) via JNK/NF-KappaB/AP-1-dependent pathways in human B cells PubMed
    tat The transcription factors NF-KappaB and NF-AT contribute to the Tat-induced activation of the HERV-K (HML-2) gag RNA transcripts in Jurkat T cells and in primary lymphocytes PubMed
    tat HIV-1 Tat enhances the NFkappaB activity and promotes the transcriptional activation of MIP-1alpha by interacting with IkappaB-alpha and p65 RelA PubMed
    tat MiR-217 regulates HIV-1 Tat-induced activation of NF-kappaB and inactivation of AMPK in MAGI cells PubMed
    tat Inhibition of human telomerase reverse transcriptase (hTERT) results in the upregulation of HIV-1 Tat-induced overexpression of intercellular adhesion molecule-1 (ICAM1) via the nuclear factor-kappaB-regulated mechanism PubMed
    tat Acetylation-deficient cyclin T1 mutant dominantly suppresses NF-kappaB-mediated activation of the interleukin-8 promoter but continues to synergize with the HIV Tat protein to transactivate the HIV long terminal repeat PubMed
    tat Herpes virus saimiri-StpC synergizes with Tat during transcriptional activation of the HIV-1 LTR. This transcriptional synergy between StpC and Tat requires Lck and NF-kappaB consensus binding sequences PubMed
    tat Specific C/EBP and NF-kappaB transcription factor binding elements within the IL-1beta promoter are involved in Tat regulation of IL-1beta production PubMed
    tat Treatment of astrocytes with cell-permeable superoxide dismutase (SOD) leads to a decrease in Tat-induced ROS generation and NF-kappaB activation PubMed
    tat Glutamic acids at positions 92, 94, and 96 or lysine's at positions 88, 89, and 90 in the second encoding Tat exon are critical for the activation of NF-kappaB PubMed
    tat HIV-1 Tat binds the deacetylase domain (amino acids 341-512) of SIRT1 and inhibits SIRT1 deacetylase activity, which results in the induction of NF-kappaB hyperacetylation PubMed
    tat HIV-1 Tat-mediated upregulation of MMP-9 in human astrocytes results from NF-kappaB activation pathway PubMed
    tat PPARalpha and PPARgamma over-expression prevent Tat-induced binding activity and transactivation of nuclear factor-kappaB PubMed
    tat NFKB1 is downregulated in HIV-1 Tat and NC cotransfection of HEK 293T cells PubMed
    tat HIV-1 Tat in combination with IFN-gamma and TNF-alpha increases CXCL10 mRNA and protein in human astrocytes through the activation of the p38, Jnk, and Akt signaling pathways and their downstream transcription factors, NF-kappaB and STAT-1alpha PubMed
    tat NFAT-1 negatively regulates HIV-1 Tat-mediated transactivation of the HIV-1 LTR by competing with NFkappaB for its binding to the LTR, thereby blocking the interaction of NFkappaB with Tat PubMed
    tat HIV-1 Tat activates NFkappaB through the cellular interferon-inducible, double-stranded RNA dependent protein kinase, PKR PubMed
    tat Activation of NFkappaB by HIV-1 Tat leads to a reduction in adenylyl cyclase activity and an inhibition of cAMP synthesis PubMed
    tat Activation of NFkappaB by HIV-1 Tat is inhibited by Nitric Oxide PubMed
    tat HIV-1 Tat-induced SOCS3 expression inhibits antiviral IFN-beta signaling to enhance HIV-1 replication in macrophages in a NF-kappaB-dependent manner PubMed
    tat Recombinant CD40L synergizes with HIV-1 Tat to increase TNF-alpha release from primary human monocytes and microglia in an NF-kappaB-dependent manner. This synergism is attributed to a Tat-mediated up-regulation of CD40 PubMed
    tat In HIV-1 Tat-expressing and HIV-infected astrocytes, endothelin-1 (ET-1) is significantly elevated through NF-kappaB (NF-kappaB)-responsive sites in the ET-1 promoter PubMed
    tat NFkappaB tethers the p160 nuclear receptor co-activator GRIP1 to the HIV-1 LTR promoter, thereby regulating the full activation of this promoter by HIV-1 Tat PubMed
    tat HIV-1 Tat has been shown to bind NFkappaB in vitro in gel shift, GST-pull down and affinity matrix assays PubMed
    tat p56-lck plays a critical role in the activation of NFkappaB by HIV-1 Tat PubMed
    tat HIV-1 Tat enhances tumor necrosis factor-induced activation of NFkappaB by downregulating manganese-dependent superoxide dismutase (MnSOD) PubMed
    Vpr vpr HIV-1 Vpr activates NFKB1 dependent upon amino acids A30, A59, H71, R73, S79, and R80 in Vpr in HeLa cells transfected with an NF-kB luciferase reporter plasmid PubMed
    vpr HIV-1 Vpr activates NFKB1 in HeLa cells transfected with an NF-kB luciferase reporter plasmid, which leads to G2 cell cycle arrest PubMed
    vpr Upregulation of IL-6, IL-10, TNFalpha, and gamma interferon is linked to HIV-1 Vpr activation of NF-kappa B PubMed
    vpr TNF secreted by HIV-1-infected cells (which may be attributed to Vpr) enhances NFKB1 (NK-kappa-B) activity in bystander cells AND induces replication of HIV-1 (reactivation) in a model of latently infected cells (J-Lat 10.6 cells) PubMed
    vpr HIV-1 Vpr induced upregulation CXCL8 (IL8) involves PI3K/Akt mediated activation of NFKB1 (NF-kappa-B) in astrocytes PubMed
    vpr HIV-1 Vpr induced upregulation of IL6 involves PI3K/Akt mediated activation of NFKB1 (NF-kappa-B) in astrocytes PubMed
    vpr HIV-1 Vpr-mediated upregulation of CXCL8 (IL8) involves NFKB1 (NF-kappa-B) PubMed
    vpr HIV-1 Vpr-mediated upregulation of IL6 involves NFKB1 (NF-kappa-B) PubMed
    vpr HIV-1 and SIVcpz Vpr proteins inhibit NF-kappaB, but the opposite is observed for SIVgsn/mus/mon Vpr proteins PubMed
    vpr HIV-1 Vpr regulates NF-kappa B, activating it in certain circumstances while suppressing it in others PubMed
    vpr The ability of HIV-1 Vpr to activate NF-kappaB or activator protein 1-dependent luciferase expression requires TAK1, TRAF6, or TAB3 in cells PubMed
    vpr HIV-1 Vpr-induced upregulation of CCL5 requires p50 and p65 subunits of NF-kappaB, p38delta MAPK, Akt-2 and Akt-3, and AP-1 transcription factor in HIV-1 Vpr transfected astrocytes PubMed
    vpr HIV-1 Vpr interacts with RelB to promote the Vpr-mediated activation of NF-kappaB reporter gene and to enhance the transactivation of HIV LTR PubMed
    vpr HIV-1 Vpr inhibits the NFkappaB signaling pathway in TNF-alpha treated cells and abolishes the phosphorylation of NFkappaB p65 subunit in response to such treatment PubMed
    vpr HIV-1 Vpr-induced IL-6 production depends on the activation of NFkappaB and the involvement of C/EBP-beta, TLR4, and MyD88 PubMed
    vpr Recruitment of PARP-1 by HIV-1 Vpr-glucocorticoid receptor (GR) complex prevents its nuclear localization, which is necessary for Vpr to suppress NF-kappaB PubMed
    vpr HIV-1 Vpr activation of NF-kappa B regulated promoters is linked to Vpr regulation of IL-12, CD44, Toll-like receptor 4, indolamine 2,3-dioxygenase, macrophage receptor with collagenous structure, and thrombospondin 1 PubMed
    vpr HIV-1 Vpr potentiates the trans-activation, but not the trans-repression, properties of the glucocorticoid receptor on NF-kappa B-regulated simple promoters PubMed
    vpr HIV-1 Vpr increases IL-8 expression and IL-8 promoter activity by activating transcription factors NF-kappa B and NF-IL-6 and also increases transcription of NF-kappa B and NF-IL-6 enhancer containing viral promoters PubMed
    vpr NF-kappa B contributes to HIV-1 transactivation by HIV-1 Vpr but is not completely responsible for this effect PubMed
    vpr Data suggests that p300, through its interactions with NF-kappa B, basal transcriptional components, and Cdks, is modulated by HIV-1 Vpr and regulates HIV replication PubMed
    vpr Vpr suppresses expression of IL-2, IL-10, IL-12, TNFalpha and IL-4, all of which are NF-kappa B-dependent PubMed
    vpr Regulation of apoptosis by HIV-1 Vpr is linked to Vpr suppression of NF-kappa B activity via the induction of I kappa B and is mapped to the first alpha-helical domain (amino acids 17-34) of Vpr PubMed
    Vpu vpu HIV-1 Vpu modulates NFKB1 activation PubMed
    vpu HIV-1 Vpu inhibits NF-kappa B activation by interfering with beta-TrCP-mediated degradation of IkappaB-alpha PubMed
    vpu Most HIV-1 and primate lentiviral Vpu proteins inhibit IKK-beta-induced NF-kappaB activation except HIV-1 group N Vpu proteins PubMed
    vpu HIV-1 Vpu inhibits endogenous expression BST2-induced NF-kappaB activity in cells, and the inhibition requires the beta-TrCP binding motif (residues 51-56; DSGxxS) in Vpu PubMed
    vpu NF-kappaB-mediated enhancement of the IFN-beta promoter activity is inhibited by HIV-1 Vpu PubMed
    vpu HIV-1 Vpu interferes with beta-TrCP to inhibit TNF-alpha-induced activation of NFkappaB PubMed
    capsid gag HIV-1 CA mutants N74D and P90A fail to bind to CPSF6 and cyclophilins (Nup358 and CypA), respectively, and trigger innate sensors, leading to nuclear translocation of NFkappaB and IRF3, production of type 1 IFN and induction of an antiviral state PubMed
    nucleocapsid gag NFKB1 (Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1) is downregulated in HIV-1 Tat and NC cotransfection of HEK 293T cells PubMed
    gag HIV-1 Nucleocapsid has been shown to bind to the HIV-1 LTR promoter and enhance NF-kappaB, Sp1, and TFIIB-induced HIV-1 LTR-directed RNA transcription PubMed
    retropepsin gag-pol HIV-1 protease can cleave p105 into a p45 maturation product and increases levels of active nuclear NF-kappa B complex PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC54151, DKFZp686C01211

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    DNA-binding transcription activator activity, RNA polymerase II-specific IDA
    Inferred from Direct Assay
    more info
    PubMed 
    DNA-binding transcription factor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    DNA-binding transcription factor activity, RNA polymerase II-specific ISA
    Inferred from Sequence Alignment
    more info
     
    DNA-binding transcription factor activity, RNA polymerase II-specific ISM
    Inferred from Sequence Model
    more info
    PubMed 
    DNA-binding transcription factor activity, RNA polymerase II-specific NAS
    Non-traceable Author Statement
    more info
    PubMed 
    DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
    Inferred from Direct Assay
    more info
    PubMed 
    RNA polymerase II distal enhancer sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    RNA polymerase II regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    RNA polymerase II regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    actinin binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    chromatin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein heterodimerization activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein homodimerization activity IEA
    Inferred from Electronic Annotation
    more info
     
    transcription factor binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    transcription regulatory region DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    transcription regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    Fc-epsilon receptor signaling pathway TAS
    Traceable Author Statement
    more info
     
    I-kappaB kinase/NF-kappaB signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    NIK/NF-kappaB signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    T cell receptor signaling pathway TAS
    Traceable Author Statement
    more info
     
    apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to angiotensin IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cellular response to dsRNA IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to interleukin-1 IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    cellular response to interleukin-6 IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cellular response to lipopolysaccharide IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cellular response to mechanical stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    cellular response to nicotine IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cellular response to tumor necrosis factor IEA
    Inferred from Electronic Annotation
    more info
     
    inflammatory response IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    inflammatory response TAS
    Traceable Author Statement
    more info
    PubMed 
    interleukin-1-mediated signaling pathway TAS
    Traceable Author Statement
    more info
     
    membrane protein intracellular domain proteolysis TAS
    Traceable Author Statement
    more info
     
    negative regulation of apoptotic process TAS
    Traceable Author Statement
    more info
    PubMed 
    negative regulation of calcidiol 1-monooxygenase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of cellular protein metabolic process IC
    Inferred by Curator
    more info
    PubMed 
    negative regulation of cholesterol transport IC
    Inferred by Curator
    more info
    PubMed 
    negative regulation of gene expression IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of inflammatory response IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of interleukin-12 biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    negative regulation of transcription by RNA polymerase II IC
    Inferred by Curator
    more info
    PubMed 
    negative regulation of transcription by RNA polymerase II IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    negative regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of vitamin D biosynthetic process IC
    Inferred by Curator
    more info
    PubMed 
    neutrophil degranulation TAS
    Traceable Author Statement
    more info
     
    positive regulation of NF-kappaB transcription factor activity TAS
    Traceable Author Statement
    more info
     
    positive regulation of canonical Wnt signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of hyaluronan biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of lipid storage IC
    Inferred by Curator
    more info
    PubMed 
    positive regulation of macrophage derived foam cell differentiation IC
    Inferred by Curator
    more info
    PubMed 
    positive regulation of miRNA metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of transcription, DNA-templated IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of transcription, DNA-templated IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of transcription, DNA-templated NAS
    Non-traceable Author Statement
    more info
    PubMed 
    positive regulation of type I interferon production TAS
    Traceable Author Statement
    more info
     
    response to cytokine IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    response to muscle stretch IEA
    Inferred from Electronic Annotation
    more info
     
    stimulatory C-type lectin receptor signaling pathway TAS
    Traceable Author Statement
    more info
     
    stress-activated MAPK cascade TAS
    Traceable Author Statement
    more info
     
    transcription by RNA polymerase II TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    I-kappaB/NF-kappaB complex TAS
    Traceable Author Statement
    more info
    PubMed 
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytosol IDA
    Inferred from Direct Assay
    more info
     
    cytosol TAS
    Traceable Author Statement
    more info
     
    extracellular region TAS
    Traceable Author Statement
    more info
     
    mitochondrion IDA
    Inferred from Direct Assay
    more info
     
    nuclear chromatin ISA
    Inferred from Sequence Alignment
    more info
     
    nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    nucleoplasm TAS
    Traceable Author Statement
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    secretory granule lumen TAS
    Traceable Author Statement
    more info
     
    specific granule lumen TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    nuclear factor NF-kappa-B p105 subunit
    Names
    DNA-binding factor KBF1
    NF-kappabeta
    nuclear factor NF-kappa-B p50 subunit
    nuclear factor kappa-B DNA binding subunit
    nuclear factor of kappa light polypeptide gene enhancer in B-cells 1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_050628.1 RefSeqGene

      Range
      5031..120974
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_1316

    mRNA and Protein(s)

    1. NM_001165412.2NP_001158884.1  nuclear factor NF-kappa-B p105 subunit isoform 2 proprotein

      See identical proteins and their annotated locations for NP_001158884.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is 1 amino acid shorter than isoform 1. Variants 2 and 3 encode the same isoform (2).
      Source sequence(s)
      AF213884, AI076882, BC051765, M58603
      Consensus CDS
      CCDS54783.1
      UniProtKB/Swiss-Prot
      P19838
      UniProtKB/TrEMBL
      A0A024RDJ4
      Related
      ENSP00000378297.4, ENST00000394820.8
      Conserved Domains (7) summary
      cd07935
      Location:42243
      RHD-n_NFkB1; N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor of kappa B1 (NF-kappa B1)
      cd00204
      Location:576705
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd01177
      Location:250351
      IPT_NFkappaB; IPT domain of the transcription factor NFkappaB and related transcription factors. NFkappaB is considered a central regulator of stress responses, activated by different stressful conditions, including physical stress, oxidative stress, and exposure to ...
      cd08797
      Location:815890
      Death_NFkB1_p105; Death domain of the Nuclear Factor-KappaB1 precursor protein p105
      sd00045
      Location:542579
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:525612
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:685733
      Ank_4; Ankyrin repeats (many copies)
    2. NM_001319226.2NP_001306155.1  nuclear factor NF-kappa-B p105 subunit isoform 2 proprotein

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in its 5' UTR and uses an alternate in-frame splice site in the 5' coding region compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is 1 amino acid shorter than isoform 1. Variants 2 and 3 encode the same isoform (2).
      Source sequence(s)
      AF213884, AI076882, BC051765, DB151710, M58603
      Consensus CDS
      CCDS54783.1
      UniProtKB/Swiss-Prot
      P19838
      UniProtKB/TrEMBL
      A0A024RDJ4
      Related
      ENSP00000424790.1, ENST00000505458.5
      Conserved Domains (7) summary
      cd07935
      Location:42243
      RHD-n_NFkB1; N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor of kappa B1 (NF-kappa B1)
      cd00204
      Location:576705
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd01177
      Location:250351
      IPT_NFkappaB; IPT domain of the transcription factor NFkappaB and related transcription factors. NFkappaB is considered a central regulator of stress responses, activated by different stressful conditions, including physical stress, oxidative stress, and exposure to ...
      cd08797
      Location:815890
      Death_NFkB1_p105; Death domain of the Nuclear Factor-KappaB1 precursor protein p105
      sd00045
      Location:542579
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:525612
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:685733
      Ank_4; Ankyrin repeats (many copies)
    3. NM_003998.4NP_003989.2  nuclear factor NF-kappa-B p105 subunit isoform 1

      See identical proteins and their annotated locations for NP_003989.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1). This isoform (1) may undergo proteolytic processing similar to that of isoform 2.
      Source sequence(s)
      AF213884, AI076882, BC051765
      Consensus CDS
      CCDS3657.1
      UniProtKB/Swiss-Prot
      P19838
      Related
      ENSP00000226574.4, ENST00000226574.9
      Conserved Domains (7) summary
      cd07935
      Location:43244
      RHD-n_NFkB1; N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor of kappa B1 (NF-kappa B1)
      cd00204
      Location:577706
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd01177
      Location:251352
      IPT_NFkappaB; IPT domain of the transcription factor NFkappaB and related transcription factors. NFkappaB is considered a central regulator of stress responses, activated by different stressful conditions, including physical stress, oxidative stress, and exposure to ...
      cd08797
      Location:816891
      Death_NFkB1_p105; Death domain of the Nuclear Factor-KappaB1 precursor protein p105
      sd00045
      Location:543580
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:526613
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:686734
      Ank_4; Ankyrin repeats (many copies)

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000004.12 Reference GRCh38.p13 Primary Assembly

      Range
      102501266..102617302
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024454069.1XP_024309837.1  nuclear factor NF-kappa-B p105 subunit isoform X4

      Conserved Domains (7) summary
      cd00204
      Location:532661
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd01177
      Location:206307
      IPT_NFkappaB; IPT domain of the transcription factor NFkappaB and related transcription factors. NFkappaB is considered a central regulator of stress responses, activated by different stressful conditions, including physical stress, oxidative stress, and exposure to ...
      cd08797
      Location:771846
      Death_NFkB1_p105; Death domain of the Nuclear Factor-KappaB1 precursor protein p105
      sd00045
      Location:498535
      ANK; ANK repeat [structural motif]
      cl08275
      Location:51199
      RHD-n; N-terminal sub-domain of the Rel homology domain (RHD)
      pfam12796
      Location:481568
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:641689
      Ank_4; Ankyrin repeats (many copies)
    2. XM_024454067.1XP_024309835.1  nuclear factor NF-kappa-B p105 subunit isoform X1

      Conserved Domains (7) summary
      cd07935
      Location:51252
      RHD-n_NFkB1; N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor of kappa B1 (NF-kappa B1)
      cd00204
      Location:585714
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd01177
      Location:259360
      IPT_NFkappaB; IPT domain of the transcription factor NFkappaB and related transcription factors. NFkappaB is considered a central regulator of stress responses, activated by different stressful conditions, including physical stress, oxidative stress, and exposure to ...
      cd08797
      Location:824899
      Death_NFkB1_p105; Death domain of the Nuclear Factor-KappaB1 precursor protein p105
      sd00045
      Location:551588
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:534621
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:694742
      Ank_4; Ankyrin repeats (many copies)
    3. XM_011532006.2XP_011530308.1  nuclear factor NF-kappa-B p105 subunit isoform X2

      Conserved Domains (8) summary
      cd07935
      Location:50251
      RHD-n_NFkB1; N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor of kappa B1 (NF-kappa B1)
      cd00204
      Location:584713
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd01177
      Location:258359
      IPT_NFkappaB; IPT domain of the transcription factor NFkappaB and related transcription factors. NFkappaB is considered a central regulator of stress responses, activated by different stressful conditions, including physical stress, oxidative stress, and exposure to ...
      cd08797
      Location:823898
      Death_NFkB1_p105; Death domain of the Nuclear Factor-KappaB1 precursor protein p105
      pfam12796
      Location:594688
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:551610
      Ank_4; Ankyrin repeats (many copies)
      pfam13857
      Location:678734
      Ank_5; Ankyrin repeats (many copies)
      sd00045
      Location:550587
      ANK; ANK repeat [structural motif]
    4. XM_024454068.1XP_024309836.1  nuclear factor NF-kappa-B p105 subunit isoform X3

      Conserved Domains (7) summary
      cd07935
      Location:43244
      RHD-n_NFkB1; N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor of kappa B1 (NF-kappa B1)
      cd00204
      Location:577706
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd01177
      Location:251352
      IPT_NFkappaB; IPT domain of the transcription factor NFkappaB and related transcription factors. NFkappaB is considered a central regulator of stress responses, activated by different stressful conditions, including physical stress, oxidative stress, and exposure to ...
      cd08797
      Location:816891
      Death_NFkB1_p105; Death domain of the Nuclear Factor-KappaB1 precursor protein p105
      sd00045
      Location:543580
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:526613
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:686734
      Ank_4; Ankyrin repeats (many copies)
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