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    NDUFA7 NADH:ubiquinone oxidoreductase subunit A7 [ Homo sapiens (human) ]

    Gene ID: 4701, updated on 8-Jul-2021

    Summary

    Official Symbol
    NDUFA7provided by HGNC
    Official Full Name
    NADH:ubiquinone oxidoreductase subunit A7provided by HGNC
    Primary source
    HGNC:HGNC:7691
    See related
    Ensembl:ENSG00000267855 MIM:602139
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    B14.5a; CI-B14.5a
    Summary
    This gene encodes a subunit of NADH:ubiquinone oxidoreductase (complex I), which is a multiprotein complex located in the inner mitochondrial membrane. Complex I functions in the transfer of electrons from NADH to the respiratory chain. [provided by RefSeq, Mar 2011]
    Expression
    Ubiquitous expression in heart (RPKM 24.4), kidney (RPKM 16.8) and 25 other tissues See more
    Orthologs
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    Genomic context

    See NDUFA7 in Genome Data Viewer
    Location:
    19p13.2
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    109.20210514 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (8308595..8321375, complement)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (8373479..8386259, complement)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene ceramide synthase 4 Neighboring gene uncharacterized LOC107985282 Neighboring gene CD320 molecule Neighboring gene ribosomal protein S28 Neighboring gene KN motif and ankyrin repeat domains 3 Neighboring gene ribosomal protein L17 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables NADH dehydrogenase (ubiquinone) activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables structural constituent of ribosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in mitochondrial electron transport, NADH to ubiquinone IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in mitochondrial electron transport, NADH to ubiquinone NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in mitochondrial translation ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane TAS
    Traceable Author Statement
    more info
     
    part_of mitochondrial respiratory chain complex I IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of mitochondrial respiratory chain complex I IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of mitochondrial respiratory chain complex I NAS
    Non-traceable Author Statement
    more info
    PubMed 
    located_in mitochondrial ribosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
     

    General protein information

    Preferred Names
    NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7
    Names
    NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 7, 14.5kDa
    NADH-ubiquinone oxidoreductase subunit B14.5a
    complex I B14.5a subunit

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_028213.2 RefSeqGene

      Range
      5022..15113
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_005001.5NP_004992.2  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7

      See identical proteins and their annotated locations for NP_004992.2

      Status: REVIEWED

      Source sequence(s)
      AC010323, BC003102
      Consensus CDS
      CCDS42492.1
      UniProtKB/Swiss-Prot
      O95182
      Related
      ENSP00000301457.1, ENST00000301457.3
      Conserved Domains (1) summary
      pfam07347
      Location:5102
      CI-B14_5a; NADH:ubiquinone oxidoreductase subunit B14.5a (Complex I-B14.5a)

    RNA

    1. NR_135539.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC010323, BC003102, CR975510

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

      Range
      8308595..8321375 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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