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    MYL4 myosin light chain 4 [ Homo sapiens (human) ]

    Gene ID: 4635, updated on 17-Jun-2019

    Summary

    Official Symbol
    MYL4provided by HGNC
    Official Full Name
    myosin light chain 4provided by HGNC
    Primary source
    HGNC:HGNC:7585
    See related
    Ensembl:ENSG00000198336 MIM:160770
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    GT1; ALC1; AMLC; PRO1957
    Summary
    Myosin is a hexameric ATPase cellular motor protein. It is composed of two myosin heavy chains, two nonphosphorylatable myosin alkali light chains, and two phosphorylatable myosin regulatory light chains. This gene encodes a myosin alkali light chain that is found in embryonic muscle and adult atria. Two alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
    Expression
    Restricted expression toward heart (RPKM 587.0) See more
    Orthologs

    Genomic context

    See MYL4 in Genome Data Viewer
    Location:
    17q21.32
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    109.20190607 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (47209017..47227650)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (45266728..45301045)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene protein GVQW1-like Neighboring gene cell division cycle 27 Neighboring gene ribosomal protein S2 pseudogene 47 Neighboring gene RNA, U7 small nuclear 186 pseudogene Neighboring gene integrin subunit beta 3 Neighboring gene uncharacterized LOC107985029

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat Treatment of human brain endothelial cells with Tat markedly elevates GTP-RhoA levels and the potential downstream effectors, such as myosin phosphatase target subunit 1 and myosin light chain PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from BioSystems

    • Adrenergic signaling in cardiomyocytes, organism-specific biosystem (from KEGG)
      Adrenergic signaling in cardiomyocytes, organism-specific biosystemCardiac myocytes express at least six subtypes of adrenergic receptor (AR) which include three subtypes of beta-AR (beta-1, beta-2, beta-3) and three subtypes of the alpha-1-AR (alpha-1A, alpha-1B, a...
    • Adrenergic signaling in cardiomyocytes, conserved biosystem (from KEGG)
      Adrenergic signaling in cardiomyocytes, conserved biosystemCardiac myocytes express at least six subtypes of adrenergic receptor (AR) which include three subtypes of beta-AR (beta-1, beta-2, beta-3) and three subtypes of the alpha-1-AR (alpha-1A, alpha-1B, a...
    • Apelin signaling pathway, organism-specific biosystem (from KEGG)
      Apelin signaling pathway, organism-specific biosystemApelin is an endogenous peptide capable of binding the apelin receptor (APJ), which was originally described as an orphan G-protein-coupled receptor. Apelin and APJ are widely expressed in various ti...
    • Cardiac muscle contraction, organism-specific biosystem (from KEGG)
      Cardiac muscle contraction, organism-specific biosystemContraction of the heart is a complex process initiated by the electrical excitation of cardiac myocytes (excitation-contraction coupling, ECC). In cardiac myocytes, Ca2+ influx induced by activation...
    • Cardiac muscle contraction, conserved biosystem (from KEGG)
      Cardiac muscle contraction, conserved biosystemContraction of the heart is a complex process initiated by the electrical excitation of cardiac myocytes (excitation-contraction coupling, ECC). In cardiac myocytes, Ca2+ influx induced by activation...
    • Muscle contraction, organism-specific biosystem (from REACTOME)
      Muscle contraction, organism-specific biosystemIn this module, the processes by which calcium binding triggers actin - myosin interactions and force generation in smooth and striated muscle tissues are annotated.
    • Myometrial Relaxation and Contraction Pathways, organism-specific biosystem (from WikiPathways)
      Myometrial Relaxation and Contraction Pathways, organism-specific biosystemThis pathway illustrates signaling networks implicated in uterine muscle contraction at labor and quiescence throughout gestation (pregnancy). The muscle of the uterus, responsible for contractile ac...
    • Striated Muscle Contraction, organism-specific biosystem (from REACTOME)
      Striated Muscle Contraction, organism-specific biosystemStriated muscle contraction is a process whereby force is generated within striated muscle tissue, resulting in a change in muscle geometry, or in short, increased force being exerted on the tendons....
    • Striated Muscle Contraction, organism-specific biosystem (from WikiPathways)
      Striated Muscle Contraction, organism-specific biosystemMuscle contraction is the process where muscle tissue is activated by a signal from the nervous system. In case of voluntary action the nervous signals are initiated from the brain by so called actio...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    actin filament binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    actin monomer binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    myosin II heavy chain binding NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    cardiac muscle contraction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    muscle filament sliding TAS
    Traceable Author Statement
    more info
     
    positive regulation of ATPase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of the force of heart contraction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    A band IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cytosol TAS
    Traceable Author Statement
    more info
     
    myosin complex IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    myosin light chain 4
    Names
    myosin light chain 1, embryonic muscle/atrial isoform
    myosin light chain alkali GT-1 isoform
    myosin, atrial/fetal muscle, light chain
    myosin, light chain 4, alkali; atrial, embryonic
    myosin, light polypeptide 4, alkali; atrial, embryonic

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_052847.1 RefSeqGene

      Range
      5046..19663
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001002841.1NP_001002841.1  myosin light chain 4

      See identical proteins and their annotated locations for NP_001002841.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript.
      Source sequence(s)
      BC030228, BU658678, H83803
      Consensus CDS
      CCDS11510.1
      UniProtKB/Swiss-Prot
      P12829
      Related
      ENSP00000347055.1, ENST00000354968.5
      Conserved Domains (2) summary
      PTZ00184
      Location:49196
      PTZ00184; calmodulin; Provisional
      cd00051
      Location:134195
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    2. NM_002476.2NP_002467.1  myosin light chain 4

      See identical proteins and their annotated locations for NP_002467.1

      Status: REVIEWED

      Source sequence(s)
      X58851
      Consensus CDS
      CCDS11510.1
      UniProtKB/Swiss-Prot
      P12829
      Related
      ENSP00000377096.1, ENST00000393450.5
      Conserved Domains (2) summary
      PTZ00184
      Location:49196
      PTZ00184; calmodulin; Provisional
      cd00051
      Location:134195
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

      Range
      47209017..47227650
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017024683.1XP_016880172.1  myosin light chain 4 isoform X1

      Conserved Domains (1) summary
      cl25352
      Location:86227
      EFh_PEF; The penta-EF hand (PEF) family
    2. XM_005257391.5XP_005257448.1  myosin light chain 4 isoform X2

      See identical proteins and their annotated locations for XP_005257448.1

      UniProtKB/Swiss-Prot
      P12829
      Related
      ENSP00000461570.1, ENST00000572316.5
      Conserved Domains (2) summary
      PTZ00184
      Location:49196
      PTZ00184; calmodulin; Provisional
      cd00051
      Location:134195
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    3. XM_011524839.2XP_011523141.2  myosin light chain 4 isoform X1

      Conserved Domains (1) summary
      cl25352
      Location:86227
      EFh_PEF; The penta-EF hand (PEF) family
    4. XM_024450766.1XP_024306534.1  myosin light chain 4 isoform X1

      Conserved Domains (1) summary
      cl25352
      Location:86227
      EFh_PEF; The penta-EF hand (PEF) family
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