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    MYH4 myosin heavy chain 4 [ Homo sapiens (human) ]

    Gene ID: 4622, updated on 17-Jun-2019

    Summary

    Official Symbol
    MYH4provided by HGNC
    Official Full Name
    myosin heavy chain 4provided by HGNC
    Primary source
    HGNC:HGNC:7574
    See related
    Ensembl:ENSG00000264424 MIM:160742
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MYH2B; MyHC-2B; MyHC-IIb
    Expression
    Low expression observed in reference dataset See more
    Orthologs

    Genomic context

    See MYH4 in Genome Data Viewer
    Location:
    17p13.1
    Exon count:
    40
    Annotation release Status Assembly Chr Location
    109.20190607 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (10443058..10469559, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (10346607..10372876, complement)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107985004 Neighboring gene myosin heavy chain 13 Neighboring gene myosin heavy chain gene cluster antisense RNA Neighboring gene myosin heavy chain 8 Neighboring gene myosin heavy chain 1 Neighboring gene myosin heavy chain 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    • Membrane Trafficking, organism-specific biosystem (from REACTOME)
      Membrane Trafficking, organism-specific biosystemThe secretory membrane system allows a cell to regulate delivery of newly synthesized proteins, carbohydrates, and lipids to the cell surface, a necessity for growth and homeostasis. The system is ma...
    • Tight junction, organism-specific biosystem (from KEGG)
      Tight junction, organism-specific biosystemTight junctions (TJs) are essential for establishing a selectively permeable barrier to diffusion through the paracellular space between neighboring cells. TJs are composed of at least three types of...
    • Tight junction, conserved biosystem (from KEGG)
      Tight junction, conserved biosystemTight junctions (TJs) are essential for establishing a selectively permeable barrier to diffusion through the paracellular space between neighboring cells. TJs are composed of at least three types of...
    • Translocation of GLUT4 to the plasma membrane, organism-specific biosystem (from REACTOME)
      Translocation of GLUT4 to the plasma membrane, organism-specific biosystemIn adipocytes and myocytes insulin signaling causes intracellular vesicles carrying the GLUT4 (SLC2A4) glucose transporter to translocate to the plasma membrane, allowing the cells to take up glucose...
    • Vesicle-mediated transport, organism-specific biosystem (from REACTOME)
      Vesicle-mediated transport, organism-specific biosystemThe transit of proteins and other cargo through the cell requires a cellular transport process in which transported substances are moved in membrane-bounded vesicles. Transported substances are enclo...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    ATPase activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    actin filament binding IEA
    Inferred from Electronic Annotation
    more info
     
    calmodulin binding IEA
    Inferred from Electronic Annotation
    more info
     
    double-stranded RNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    microfilament motor activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    ATP metabolic process NAS
    Non-traceable Author Statement
    more info
    PubMed 
    actin filament-based movement NAS
    Non-traceable Author Statement
    more info
    PubMed 
    muscle contraction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    muscle filament sliding NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    muscle myosin complex NAS
    Non-traceable Author Statement
    more info
    PubMed 
    myofibril IDA
    Inferred from Direct Assay
    more info
    PubMed 
    myosin filament IEA
    Inferred from Electronic Annotation
    more info
     
    sarcomere NAS
    Non-traceable Author Statement
    more info
    PubMed 

    General protein information

    Preferred Names
    myosin-4
    Names
    myosin heavy chain 2b
    myosin heavy chain IIb
    myosin heavy chain, skeletal muscle, fetal
    myosin, heavy chain 4, skeletal muscle
    myosin, heavy polypeptide 4, skeletal muscle

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_052846.1 RefSeqGene

      Range
      5001..31270
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_017533.2NP_060003.2  myosin-4

      See identical proteins and their annotated locations for NP_060003.2

      Status: VALIDATED

      Source sequence(s)
      AC005323, AF111783
      Consensus CDS
      CCDS11154.1
      UniProtKB/Swiss-Prot
      Q9Y623
      Related
      ENSP00000255381.2, ENST00000255381.2
      Conserved Domains (8) summary
      cd14915
      Location:100770
      MYSc_Myh4; class II myosin heavy chain 4, motor domain
      pfam00063
      Location:88770
      Myosin_head; Myosin head (motor domain)
      pfam01576
      Location:8501927
      Myosin_tail_1; Myosin tail
      pfam02736
      Location:3673
      Myosin_N; Myosin N-terminal SH3-like domain
      cl00459
      Location:12991411
      MIT_CorA-like; metal ion transporter CorA-like divalent cation transporter superfamily
      cl19219
      Location:16701767
      DUF342; Protein of unknown function (DUF342)
      cl19764
      Location:13761511
      COG6; Conserved oligomeric complex COG6
      cl23720
      Location:9651098
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

      Range
      10443058..10469559 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017024676.1XP_016880165.1  myosin-4 isoform X1

      UniProtKB/Swiss-Prot
      Q9Y623
      Conserved Domains (8) summary
      cd14915
      Location:100770
      MYSc_Myh4; class II myosin heavy chain 4, motor domain
      pfam00063
      Location:88770
      Myosin_head; Myosin head (motor domain)
      pfam01576
      Location:8501927
      Myosin_tail_1; Myosin tail
      pfam02736
      Location:3673
      Myosin_N; Myosin N-terminal SH3-like domain
      cl00459
      Location:12991411
      MIT_CorA-like; metal ion transporter CorA-like divalent cation transporter superfamily
      cl19219
      Location:16701767
      DUF342; Protein of unknown function (DUF342)
      cl19764
      Location:13761511
      COG6; Conserved oligomeric complex COG6
      cl23720
      Location:9651098
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
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