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    MYH1 myosin heavy chain 1 [ Homo sapiens (human) ]

    Gene ID: 4619, updated on 17-Jun-2019

    Summary

    Official Symbol
    MYH1provided by HGNC
    Official Full Name
    myosin heavy chain 1provided by HGNC
    Primary source
    HGNC:HGNC:7567
    See related
    Ensembl:ENSG00000109061 MIM:160730
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MYHa; HEL71; MYHSA1; MyHC-2x; MyHC-2X/D
    Summary
    Myosin is a major contractile protein which converts chemical energy into mechanical energy through the hydrolysis of ATP. Myosin is a hexameric protein composed of a pair of myosin heavy chains (MYH) and two pairs of nonidentical light chains. Myosin heavy chains are encoded by a multigene family. In mammals at least 10 different myosin heavy chain (MYH) isoforms have been described from striated, smooth, and nonmuscle cells. These isoforms show expression that is spatially and temporally regulated during development. [provided by RefSeq, Jul 2008]
    Expression
    Biased expression in prostate (RPKM 4.3), esophagus (RPKM 3.5) and 2 other tissues See more
    Orthologs

    Genomic context

    See MYH1 in Genome Data Viewer
    Location:
    17p13.1
    Exon count:
    40
    Annotation release Status Assembly Chr Location
    109.20190607 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (10492307..10518719, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (10395624..10421859, complement)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene myosin heavy chain gene cluster antisense RNA Neighboring gene myosin heavy chain 8 Neighboring gene myosin heavy chain 4 Neighboring gene myosin heavy chain 2 Neighboring gene myosin heavy chain 3 Neighboring gene SCO cytochrome c oxidase assembly protein 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    • Membrane Trafficking, organism-specific biosystem (from REACTOME)
      Membrane Trafficking, organism-specific biosystemThe secretory membrane system allows a cell to regulate delivery of newly synthesized proteins, carbohydrates, and lipids to the cell surface, a necessity for growth and homeostasis. The system is ma...
    • Tight junction, organism-specific biosystem (from KEGG)
      Tight junction, organism-specific biosystemTight junctions (TJs) are essential for establishing a selectively permeable barrier to diffusion through the paracellular space between neighboring cells. TJs are composed of at least three types of...
    • Tight junction, conserved biosystem (from KEGG)
      Tight junction, conserved biosystemTight junctions (TJs) are essential for establishing a selectively permeable barrier to diffusion through the paracellular space between neighboring cells. TJs are composed of at least three types of...
    • Translocation of GLUT4 to the plasma membrane, organism-specific biosystem (from REACTOME)
      Translocation of GLUT4 to the plasma membrane, organism-specific biosystemIn adipocytes and myocytes insulin signaling causes intracellular vesicles carrying the GLUT4 (SLC2A4) glucose transporter to translocate to the plasma membrane, allowing the cells to take up glucose...
    • Vesicle-mediated transport, organism-specific biosystem (from REACTOME)
      Vesicle-mediated transport, organism-specific biosystemThe transit of proteins and other cargo through the cell requires a cellular transport process in which transported substances are moved in membrane-bounded vesicles. Transported substances are enclo...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC133384

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    actin filament binding IEA
    Inferred from Electronic Annotation
    more info
     
    calmodulin binding IEA
    Inferred from Electronic Annotation
    more info
     
    motor activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    muscle contraction IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    A band IEA
    Inferred from Electronic Annotation
    more info
     
    cytoplasmic ribonucleoprotein granule IDA
    Inferred from Direct Assay
    more info
    PubMed 
    intercalated disc IEA
    Inferred from Electronic Annotation
    more info
     
    muscle myosin complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    myosin filament IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    myosin-1
    Names
    epididymis luminal protein 71
    myHC-IIx/d
    myosin heavy chain 2x
    myosin heavy chain IIx/d
    myosin heavy chain, skeletal muscle, adult 1
    myosin, heavy chain 1, skeletal muscle, adult
    myosin, heavy polypeptide 1, skeletal muscle, adult

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_005963.4NP_005954.3  myosin-1

      See identical proteins and their annotated locations for NP_005954.3

      Status: REVIEWED

      Source sequence(s)
      AF111785, AJ573764, BC114545, DA826478
      Consensus CDS
      CCDS11155.1
      UniProtKB/Swiss-Prot
      P12882
      Related
      ENSP00000226207.5, ENST00000226207.6
      Conserved Domains (8) summary
      cd14910
      Location:100770
      MYSc_Myh1_mammals; class II myosin heavy chain 1, motor domain
      pfam00063
      Location:88770
      Myosin_head; Myosin head (motor domain)
      pfam01576
      Location:8501927
      Myosin_tail_1; Myosin tail
      pfam02736
      Location:3673
      Myosin_N; Myosin N-terminal SH3-like domain
      pfam07851
      Location:17441853
      TMPIT; TMPIT-like protein
      cl00459
      Location:12991411
      MIT_CorA-like; metal ion transporter CorA-like divalent cation transporter superfamily
      cl19219
      Location:16701767
      DUF342; Protein of unknown function (DUF342)
      cl23720
      Location:9651098
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

      Range
      10492307..10518719 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017024675.1XP_016880164.1  myosin-1 isoform X1

      UniProtKB/Swiss-Prot
      P12882
      Conserved Domains (8) summary
      cd14910
      Location:100770
      MYSc_Myh1_mammals; class II myosin heavy chain 1, motor domain
      pfam00063
      Location:88770
      Myosin_head; Myosin head (motor domain)
      pfam01576
      Location:8501927
      Myosin_tail_1; Myosin tail
      pfam02736
      Location:3673
      Myosin_N; Myosin N-terminal SH3-like domain
      pfam07851
      Location:17441853
      TMPIT; TMPIT-like protein
      cl00459
      Location:12991411
      MIT_CorA-like; metal ion transporter CorA-like divalent cation transporter superfamily
      cl19219
      Location:16701767
      DUF342; Protein of unknown function (DUF342)
      cl23720
      Location:9651098
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
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