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    MYCL MYCL proto-oncogene, bHLH transcription factor [ Homo sapiens (human) ]

    Gene ID: 4610, updated on 23-Nov-2021

    Summary

    Official Symbol
    MYCLprovided by HGNC
    Official Full Name
    MYCL proto-oncogene, bHLH transcription factorprovided by HGNC
    Primary source
    HGNC:HGNC:7555
    See related
    Ensembl:ENSG00000116990 MIM:164850
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    LMYC; L-Myc; MYCL1; bHLHe38
    Expression
    Broad expression in skin (RPKM 18.4), pancreas (RPKM 11.3) and 17 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See MYCL in Genome Data Viewer
    Location:
    1p34.2
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    109.20211119 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (39895428..39901917, complement)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (40361100..40367589, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105378667 Neighboring gene tRNA isopentenyltransferase 1 Neighboring gene Sharpr-MPRA regulatory region 6057 Neighboring gene MYCL antisense RNA 1 Neighboring gene major facilitator superfamily domain containing 2A Neighboring gene ribosomal protein S2 pseudogene 12 Neighboring gene uncharacterized LOC105378669

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    involved_in regulation of inner ear auditory receptor cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in chromatin ISA
    Inferred from Sequence Alignment
    more info
     
    located_in chromosome IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     

    General protein information

    Preferred Names
    protein L-Myc
    Names
    class E basic helix-loop-helix protein 38
    l-myc-1 proto-oncogene
    myc-related gene from lung cancer
    protein L-Myc-1
    v-myc avian myelocytomatosis viral oncogene lung carcinoma derived homolog
    v-myc myelocytomatosis viral oncogene homolog 1, lung carcinoma derived

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033081.3NP_001028253.1  protein L-Myc isoform 1

      See identical proteins and their annotated locations for NP_001028253.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes isoform 1.
      Source sequence(s)
      AI144219, AL033527
      Consensus CDS
      CCDS30682.1
      UniProtKB/Swiss-Prot
      P12524
      Related
      ENSP00000361903.2, ENST00000372816.3
      Conserved Domains (2) summary
      cd00083
      Location:279333
      HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
      pfam01056
      Location:2228
      Myc_N; Myc amino-terminal region
    2. NM_001033082.3NP_001028254.2  protein L-Myc isoform 3

      See identical proteins and their annotated locations for NP_001028254.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate segment in the 5' region and uses an alternate, upstream start codon, compared to variant 1. It encodes isoform 3, which is longer than isoform 1.
      Source sequence(s)
      AI144219, AK296078, AL033527
      Consensus CDS
      CCDS53300.1
      UniProtKB/Swiss-Prot
      P12524
      Related
      ENSP00000380494.2, ENST00000397332.2
      Conserved Domains (2) summary
      cd00083
      Location:309363
      HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
      pfam01056
      Location:26258
      Myc_N; Myc amino-terminal region
    3. NM_005376.5NP_005367.2  protein L-Myc isoform 2

      See identical proteins and their annotated locations for NP_005367.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) has multiple differences compared to variant 1. The resulting isoform (2) has distinct N- and C-termini and is shorter than isoform 1.
      Source sequence(s)
      AL033527, BC011864, BX101968
      Consensus CDS
      CCDS44117.2
      UniProtKB/Swiss-Prot
      P12524
      Related
      ENSP00000361902.1, ENST00000372815.1
      Conserved Domains (1) summary
      pfam01056
      Location:26234
      Myc_N; Myc amino-terminal region

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

      Range
      39895428..39901917 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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