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    MYBL1 MYB proto-oncogene like 1 [ Homo sapiens (human) ]

    Gene ID: 4603, updated on 15-Jun-2019

    Summary

    Official Symbol
    MYBL1provided by HGNC
    Official Full Name
    MYB proto-oncogene like 1provided by HGNC
    Primary source
    HGNC:HGNC:7547
    See related
    Ensembl:ENSG00000185697 MIM:159405
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    AMYB; A-MYB
    Expression
    Broad expression in lymph node (RPKM 9.0), testis (RPKM 6.1) and 15 other tissues See more
    Orthologs

    Genomic context

    See MYBL1 in Genome Data Viewer
    Location:
    8q13.1
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 8 NC_000008.11 (66562175..66613249, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (67474410..67525484, complement)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 32kDa pseudogene Neighboring gene RNA, U6 small nuclear 1324, pseudogene Neighboring gene vexin Neighboring gene uncharacterized LOC105375884 Neighboring gene valosin containing protein interacting protein 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    • Gene Expression, organism-specific biosystem (from REACTOME)
      Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
    • Gene Silencing by RNA, organism-specific biosystem (from REACTOME)
      Gene Silencing by RNA, organism-specific biosystemIn this module, the biology of various types of regulatory non-coding RNAs are described. Currently, biogenesis and functions of small interfering RNAs (siRNAs) and microRNAs are annotated.
    • HTLV-I infection, organism-specific biosystem (from KEGG)
      HTLV-I infection, organism-specific biosystemHuman T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammato...
    • HTLV-I infection, conserved biosystem (from KEGG)
      HTLV-I infection, conserved biosystemHuman T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammato...
    • IL4-mediated signaling events, organism-specific biosystem (from Pathway Interaction Database)
      IL4-mediated signaling events, organism-specific biosystem
      IL4-mediated signaling events
    • PIWI-interacting RNA (piRNA) biogenesis, organism-specific biosystem (from REACTOME)
      PIWI-interacting RNA (piRNA) biogenesis, organism-specific biosystemIn germ cells of humans and mice, precursors of PIWI-interacting RNAs (piRNAs) are transcribed from a few hundred sequence clusters, as well as individual transposons, intergenic regions, and genes i...
    • Pathways Affected in Adenoid Cystic Carcinoma, organism-specific biosystem (from WikiPathways)
      Pathways Affected in Adenoid Cystic Carcinoma, organism-specific biosystemProtein pathways altered by mutations in adenoid cystic carcinoma. Pathways include epigentic modification, DNA damage checkpoint signals, MYB/MYC signalling pathway, FGF/IGF/PI3K signalling, and not...
    • Preimplantation Embryo, organism-specific biosystem (from WikiPathways)
      Preimplantation Embryo, organism-specific biosystemThe source of this pathway is RNA-Seq data from single-cell pre-implantation embryos (Supplemental Table 1): http://www.nature.com/nsmb/journal/v20/n9/full/nsmb.2660.html Analysis options for runnin...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC120059, MGC120061

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    male meiosis I ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    negative regulation of transposition ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    piRNA biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of transcription, DNA-templated IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of transcription, DNA-templated NAS
    Non-traceable Author Statement
    more info
    PubMed 
    spermatogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    nucleus NAS
    Non-traceable Author Statement
    more info
    PubMed 

    General protein information

    Preferred Names
    myb-related protein A
    Names
    myb-like protein 1
    v-myb avian myeloblastosis viral oncogene homolog-like 1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001080416.4NP_001073885.1  myb-related protein A isoform 1

      See identical proteins and their annotated locations for NP_001073885.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC083928, DR003430, X13294
      Consensus CDS
      CCDS47867.1
      UniProtKB/Swiss-Prot
      P10243
      Related
      ENSP00000429633.2, ENST00000522677.7
      Conserved Domains (4) summary
      smart00717
      Location:87135
      SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
      pfam00249
      Location:87133
      Myb_DNA-binding; Myb-like DNA-binding domain
      pfam07988
      Location:242286
      LMSTEN; LMSTEN motif
      pfam09316
      Location:486647
      Cmyb_C; C-myb, C-terminal
    2. NM_001144755.3NP_001138227.1  myb-related protein A isoform 2

      See identical proteins and their annotated locations for NP_001138227.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AC083928, BC101188, DR003430
      Consensus CDS
      CCDS55241.1
      UniProtKB/Swiss-Prot
      P10243
      Related
      ENSP00000428011.2, ENST00000524176.2
      Conserved Domains (3) summary
      pfam09316
      Location:486647
      Cmyb_C; C-myb, C-terminal
      pfam13921
      Location:3898
      Myb_DNA-bind_6; Myb-like DNA-binding domain
      cl28544
      Location:84270
      SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
    3. NM_001294282.2NP_001281211.1  myb-related protein A isoform 3

      See identical proteins and their annotated locations for NP_001281211.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an alternate in-frame exon and uses an alternate in-frame splice site, compared to variant 1. The encoded isoform (3) is shorter than isoform 1.
      Source sequence(s)
      AC083928, BC101186, DR003430
      UniProtKB/TrEMBL
      Q495G0
      Conserved Domains (3) summary
      pfam09316
      Location:485646
      Cmyb_C; C-myb, C-terminal
      pfam13921
      Location:3898
      Myb_DNA-bind_6; Myb-like DNA-binding domain
      cl28544
      Location:84270
      SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p13 Primary Assembly

      Range
      66562175..66613218 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017013455.1XP_016868944.1  myb-related protein A isoform X1

    2. XM_017013457.1XP_016868946.1  myb-related protein A isoform X4

    3. XM_011517535.3XP_011515837.1  myb-related protein A isoform X6

      Conserved Domains (4) summary
      smart00717
      Location:87135
      SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
      pfam00249
      Location:87133
      Myb_DNA-binding; Myb-like DNA-binding domain
      pfam07988
      Location:242286
      LMSTEN; LMSTEN motif
      pfam09316
      Location:491652
      Cmyb_C; C-myb, C-terminal
    4. XM_011517533.3XP_011515835.1  myb-related protein A isoform X3

      Conserved Domains (4) summary
      smart00717
      Location:87135
      SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
      pfam00249
      Location:87133
      Myb_DNA-binding; Myb-like DNA-binding domain
      pfam07988
      Location:242286
      LMSTEN; LMSTEN motif
      pfam09316
      Location:491652
      Cmyb_C; C-myb, C-terminal
    5. XM_017013456.1XP_016868945.1  myb-related protein A isoform X2

    6. XM_017013458.1XP_016868947.1  myb-related protein A isoform X5

    7. XM_017013459.1XP_016868948.1  myb-related protein A isoform X7

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