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    MUC7 mucin 7, secreted [ Homo sapiens (human) ]

    Gene ID: 4589, updated on 17-Sep-2024

    Summary

    Official Symbol
    MUC7provided by HGNC
    Official Full Name
    mucin 7, secretedprovided by HGNC
    Primary source
    HGNC:HGNC:7518
    See related
    Ensembl:ENSG00000171195 MIM:158375; AllianceGenome:HGNC:7518
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MG2
    Summary
    This gene encodes a small salivary mucin, which is thought to play a role in facilitating the clearance of bacteria in the oral cavity and to aid in mastication, speech, and swallowing. The central domain of this glycoprotein contains tandem repeats, each composed of 23 amino acids. This antimicrobial protein has antibacterial and antifungal activity. The most common allele contains 6 repeats, and some alleles may be associated with susceptibility to asthma. Alternatively spliced transcript variants with different 5' UTR, but encoding the same protein, have been found for this gene. [provided by RefSeq, Oct 2014]
    Expression
    Restricted expression toward salivary gland (RPKM 5748.3) See more
    Orthologs
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    Genomic context

    See MUC7 in Genome Data Viewer
    Location:
    4q13.3
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (70430492..70482997)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (73771521..73824025)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (71296209..71348714)

    Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene submaxillary gland androgen regulated protein 3B Neighboring gene opiorphin prepropeptide Neighboring gene amelotin Neighboring gene ReSE screen-validated silencer GRCh37_chr4:71464845-71465050 Neighboring gene ameloblastin

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    Inherited susceptibility to asthma
    MedGen: C1869116 OMIM: 600807 GeneReviews: Not available
    Compare labs

    EBI GWAS Catalog

    Description
    A quantitative-trait genome-wide association study of alcoholism risk in the community: findings and implications.
    EBI GWAS Catalog

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General protein information

    Preferred Names
    mucin-7
    Names
    MUC-7
    apo-MG2
    mucin 7, salivary
    mucin MG2
    salivary mucin-7

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_012348.2 RefSeqGene

      Range
      46707..57507
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001145006.2NP_001138478.1  mucin-7 precursor

      See identical proteins and their annotated locations for NP_001138478.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Transcript variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AC106884, AC108518
      Consensus CDS
      CCDS3541.1
      UniProtKB/Swiss-Prot
      Q8TAX7, Q9UCD7, Q9UCD8
      Related
      ENSP00000407422.1, ENST00000413702.5
      Conserved Domains (1) summary
      PRK12323
      Location:141358
      PRK12323; DNA polymerase III subunits gamma and tau; Provisional
    2. NM_001145007.2NP_001138479.1  mucin-7 precursor

      See identical proteins and their annotated locations for NP_001138479.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) contains an alternate 5' terminal non-coding exon, hence has a different 5' UTR compared to transcript variant 1. Transcript variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AC108518
      Consensus CDS
      CCDS3541.1
      UniProtKB/Swiss-Prot
      Q8TAX7, Q9UCD7, Q9UCD8
      Related
      ENSP00000400585.1, ENST00000456088.5
      Conserved Domains (1) summary
      PRK12323
      Location:141358
      PRK12323; DNA polymerase III subunits gamma and tau; Provisional
    3. NM_152291.3NP_689504.2  mucin-7 precursor

      See identical proteins and their annotated locations for NP_689504.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) represents the shortest transcript and has a different 5' UTR compared to transcript variant 1. Transcript variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AC108518
      Consensus CDS
      CCDS3541.1
      UniProtKB/Swiss-Prot
      Q8TAX7, Q9UCD7, Q9UCD8
      Related
      ENSP00000302021.5, ENST00000304887.6
      Conserved Domains (1) summary
      PRK12323
      Location:141358
      PRK12323; DNA polymerase III subunits gamma and tau; Provisional

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

      Range
      70430492..70482997
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047415723.1XP_047271679.1  mucin-7 isoform X1

      UniProtKB/Swiss-Prot
      Q8TAX7, Q9UCD7, Q9UCD8

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060928.1 Alternate T2T-CHM13v2.0

      Range
      73771521..73824025
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054350095.1XP_054206070.1  mucin-7 isoform X1

      UniProtKB/Swiss-Prot
      Q8TAX7, Q9UCD7, Q9UCD8