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    S100a11 S100 calcium binding protein A11 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 445415, updated on 9-Dec-2024

    Summary

    Official Symbol
    S100a11provided by RGD
    Official Full Name
    S100 calcium binding protein A11provided by RGD
    Primary source
    RGD:1303295
    See related
    EnsemblRapid:ENSRNOG00000010105 AllianceGenome:RGD:1303295
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable several functions, including S100 protein binding activity; calcium-dependent protein binding activity; and protein homodimerization activity. Predicted to be involved in positive regulation of smooth muscle cell migration. Predicted to be located in nucleus and ruffle. Predicted to be active in cytoplasm and extracellular space. Orthologous to human S100A11 (S100 calcium binding protein A11). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Lung (RPKM 605.9), Kidney (RPKM 299.2) and 7 other tissues See more
    Orthologs
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    Genomic context

    See S100a11 in Genome Data Viewer
    Location:
    2q34
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (181875132..181880542)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (179191688..179197098)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (193863185..193868646)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene SUMO specific peptidase 2, pseudogene 5 Neighboring gene uncharacterized LOC120100592 Neighboring gene CDC28 protein kinase regulatory subunit 1-like, pseudogene 1 Neighboring gene S100 calcium binding protein A10

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables S100 protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables S100 protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables calcium ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables calcium-dependent protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables calcium-dependent protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in positive regulation of smooth muscle cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of cell population proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    NOT acts_upstream_of_or_within spermatogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in ruffle ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    protein S100-A11
    Names
    S100 calcium binding protein A11 (calizzarin)
    calgizzarin

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001004095.2NP_001004095.1  protein S100-A11

      See identical proteins and their annotated locations for NP_001004095.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/Swiss-Prot
      Q6B345
      UniProtKB/TrEMBL
      A6KMM4
      Related
      ENSRNOP00000013393.4, ENSRNOT00000013393.8
      Conserved Domains (1) summary
      cd05023
      Location:290
      S-100A11; S-100A11 domain found in proteins similar to S100A11. S100A11 is a member of the S-100 domain family within EF-hand Ca2+-binding proteins superfamily. Note that the S-100 hierarchy, to which this S-100A11 group belongs, contains only S-100 EF-hand ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      181875132..181880542
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)