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    CT45A3 cancer/testis antigen family 45 member A3 [ Homo sapiens (human) ]

    Gene ID: 441519, updated on 10-Oct-2023

    Summary

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    Official Symbol
    CT45A3provided by HGNC
    Official Full Name
    cancer/testis antigen family 45 member A3provided by HGNC
    Primary source
    HGNC:HGNC:33268
    See related
    Ensembl:ENSG00000269096 MIM:300794; AllianceGenome:HGNC:33268
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CT45-3; CT45-4; CT45.3; CT45.4; CT45A4
    Summary
    Predicted to be involved in snRNA 3'-end processing. Predicted to be part of integrator complex. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Restricted expression toward testis (RPKM 11.8) See more
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    Genomic context

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    Location:
    Xq26.3
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (135760044..135768191, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (134103000..134111149, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (134883488..134891634)

    Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene MGAT2 pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29986 Neighboring gene MGAT2 pseudogene 2 Neighboring gene cancer/testis antigen family 45 member A5 Neighboring gene cancer/testis antigen family 45 member A6

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Identification of cancer/testis-antigen genes by massively parallel signature sequencing. Chen YT, et al. Proc Natl Acad Sci U S A, 2005 May 31. PMID 15905330, Free PMC Article
    2. The DNA sequence of the human X chromosome. Ross MT, et al. Nature, 2005 Mar 17. PMID 15772651, Free PMC Article
    3. WWP2 ubiquitylates RNA polymerase II for DNA-PK-dependent transcription arrest and repair at DNA breaks. Caron P, et al. Genes Dev, 2019 Jun 1. PMID 31048545, Free PMC Article
    4. Transcriptome analysis of human gastric cancer. Oh JH, et al. Mamm Genome, 2005 Dec. PMID 16341674
    5. Multiplexed kinase interactome profiling quantifies cellular network activity and plasticity. Golkowski M, et al. Mol Cell, 2023 Mar 2. PMID 36736316, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Clone Names

    • FLJ25823, MGC183045, MGC184299

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    cancer/testis antigen family 45 member A3
    Names
    cancer/testis antigen 45-3
    cancer/testis antigen 45-4
    cancer/testis antigen 45A3
    cancer/testis antigen 45A4
    cancer/testis antigen CT45-3
    cancer/testis antigen family 45 member A4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001017435.2 → NP_001017435.1  cancer/testis antigen family 45 member A3

      See identical proteins and their annotated locations for NP_001017435.1

      Status: VALIDATED

      Source sequence(s)
      AC240441
      Consensus CDS
      CCDS76030.1
      UniProtKB/Swiss-Prot
      B2RU20, B7ZMC9, D3DTG6, P0DMU6, Q8N7B7, Q8NHU0
      Conserved Domains (1) summary
      pfam15300
      Location:122 → 183
      INT_SG_DDX_CT_C; INTS6/SAGE1/DDX26B/CT45 C-terminus

    2. NM_001370148.2 → NP_001357077.1  cancer/testis antigen family 45 member A3

      Status: VALIDATED

      Source sequence(s)
      AC240441, AI581344, AY743711, HY033723
      Consensus CDS
      CCDS76030.1
      UniProtKB/Swiss-Prot
      B2RU20, B7ZMC9, D3DTG6, P0DMU6, Q8N7B7, Q8NHU0
      Related
      ENSP00000471571.2, ENST00000598716.3
      Conserved Domains (1) summary
      pfam15300
      Location:122 → 183
      INT_SG_DDX_CT_C; INTS6/SAGE1/DDX26B/CT45 C-terminus

    3. NM_001370149.1 → NP_001357078.1  cancer/testis antigen family 45 member A3

      Status: VALIDATED

      Source sequence(s)
      AC240441
      Consensus CDS
      CCDS76030.1
      UniProtKB/Swiss-Prot
      B2RU20, B7ZMC9, D3DTG6, P0DMU6, Q8N7B7, Q8NHU0
      Conserved Domains (1) summary
      pfam15300
      Location:122 → 183
      INT_SG_DDX_CT_C; INTS6/SAGE1/DDX26B/CT45 C-terminus

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

      Range
      135760044..135768191 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060947.1 Alternate T2T-CHM13v2.0

      Range
      134103000..134111149 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8NHU0.1 GenPept UniProtKB/Swiss-Prot:Q8NHU0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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