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    PSG8 pregnancy specific beta-1-glycoprotein 8 [ Homo sapiens (human) ]

    Gene ID: 440533, updated on 15-Jun-2019

    Summary

    Official Symbol
    PSG8provided by HGNC
    Official Full Name
    pregnancy specific beta-1-glycoprotein 8provided by HGNC
    Primary source
    HGNC:HGNC:9525
    See related
    Ensembl:ENSG00000124467 MIM:176397
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PSG1
    Summary
    The human pregnancy-specific glycoproteins (PSGs) are a group of molecules that are mainly produced by the placental syncytiotrophoblasts during pregnancy. PSGs comprise a subgroup of the carcinoembryonic antigen (CEA) family, which belongs to the immunoglobulin superfamily. For additional general information about the PSG gene family, see PSG1 (MIM 176390).[supplied by OMIM, Oct 2009]
    Expression
    Restricted expression toward placenta (RPKM 46.5) See more

    Genomic context

    See PSG8 in Genome Data Viewer
    Location:
    19q13.2
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 19 NC_000019.10 (42752687..42765692, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (43256839..43269831, complement)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene ribosomal protein S10 pseudogene 28 Neighboring gene pregnancy specific beta-1-glycoprotein 3 Neighboring gene carcinoembryonic antigen related cell adhesion molecule pseudogene 6 Neighboring gene PSG8 antisense RNA 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Pathways from BioSystems

    • Cell surface interactions at the vascular wall, organism-specific biosystem (from REACTOME)
      Cell surface interactions at the vascular wall, organism-specific biosystemLeukocyte extravasation is a rigorously controlled process that guides white cell movement from the vascular lumen to sites of tissue inflammation. The powerful adhesive interactions that are require...
    • Hemostasis, organism-specific biosystem (from REACTOME)
      Hemostasis, organism-specific biosystemHemostasis is a physiological response that culminates in the arrest of bleeding from an injured vessel. Under normal conditions the vascular endothelium supports vasodilation, inhibits platelet adhe...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • DKFZp781L10202

    Gene Ontology Provided by GOA

    Component Evidence Code Pubs
    extracellular region IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    pregnancy-specific beta-1-glycoprotein 8
    Names
    C1 alternate
    C2 alternate
    C3 alternate
    PS-beta-G-8
    PSBG-8
    pregnancy-specific beta-1 glycoprotein
    pregnancy-specific glycoprotein 8

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001130167.2NP_001123639.1  pregnancy-specific beta-1-glycoprotein 8 isoform b precursor

      See identical proteins and their annotated locations for NP_001123639.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (b) has a shorter and distinct C-terminus compared to isoform a.
      Source sequence(s)
      AC004654, BC137500, BC142628, BX114490
      Consensus CDS
      CCDS46091.1
      UniProtKB/Swiss-Prot
      Q9UQ74
      Related
      ENSP00000385869.3, ENST00000404209.8
      Conserved Domains (4) summary
      cd05774
      Location:36138
      Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
      smart00410
      Location:339411
      IG_like; Immunoglobulin like
      pfam13895
      Location:335413
      Ig_2; Immunoglobulin domain
      cl11960
      Location:148236
      Ig; Immunoglobulin domain
    2. NM_001130168.2NP_001123640.1  pregnancy-specific beta-1-glycoprotein 8 isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 3' UTR and coding sequence and lacks an alternate in-frame exon compared to variant 1. The resulting isoform (c) lacks an alternate internal segment and has a shorter and distinct C-terminus compared to isoform a.
      Source sequence(s)
      AC004654, AL545004, BC137500, BC142628, BX114490
      Consensus CDS
      CCDS46090.1
      UniProtKB/Swiss-Prot
      Q9UQ74
      Related
      ENSP00000385081.3, ENST00000406636.7
      Conserved Domains (3) summary
      smart00410
      Location:217289
      IG_like; Immunoglobulin like
      pfam13895
      Location:213291
      Ig_2; Immunoglobulin domain
      cl11960
      Location:26114
      Ig; Immunoglobulin domain
    3. NM_182707.3NP_874366.1  pregnancy-specific beta-1-glycoprotein 8 isoform a precursor

      See identical proteins and their annotated locations for NP_874366.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (a).
      Source sequence(s)
      BC137500
      Consensus CDS
      CCDS33037.1
      UniProtKB/Swiss-Prot
      Q9UQ74
      Related
      ENSP00000305005.4, ENST00000306511.4
      Conserved Domains (3) summary
      pfam13895
      Location:335413
      Ig_2; Immunoglobulin domain
      cd05774
      Location:36138
      Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
      cl11960
      Location:148236
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

      Range
      42752686..42765692 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011526986.1XP_011525288.1  pregnancy-specific beta-1-glycoprotein 8 isoform X1

      Conserved Domains (4) summary
      cd05774
      Location:36138
      Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
      smart00410
      Location:246318
      IG_like; Immunoglobulin like
      pfam13895
      Location:242320
      Ig_2; Immunoglobulin domain
      cl11960
      Location:148236
      Ig; Immunoglobulin domain
    2. XM_011526988.2XP_011525290.1  pregnancy-specific beta-1-glycoprotein 8 isoform X3

      Conserved Domains (3) summary
      smart00410
      Location:178250
      IG_like; Immunoglobulin like
      pfam13895
      Location:174252
      Ig_2; Immunoglobulin domain
      cl11960
      Location:275
      Ig; Immunoglobulin domain
    3. XM_011526987.3XP_011525289.1  pregnancy-specific beta-1-glycoprotein 8 isoform X2

      Conserved Domains (3) summary
      smart00410
      Location:226298
      IG_like; Immunoglobulin like
      pfam13895
      Location:222300
      Ig_2; Immunoglobulin domain
      cl11960
      Location:35123
      Ig; Immunoglobulin domain
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