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    MEP1A meprin A subunit alpha [ Homo sapiens (human) ]

    Gene ID: 4224, updated on 11-Jun-2021

    Summary

    Official Symbol
    MEP1Aprovided by HGNC
    Official Full Name
    meprin A subunit alphaprovided by HGNC
    Primary source
    HGNC:HGNC:7015
    See related
    Ensembl:ENSG00000112818 MIM:600388
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PPHA
    Expression
    Biased expression in small intestine (RPKM 216.8), duodenum (RPKM 122.1) and 1 other tissue See more
    Orthologs
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    Genomic context

    See MEP1A in Genome Data Viewer
    Location:
    6p12.3
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    109.20210514 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (46793384..46845987)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (46761126..46807515)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene tudor domain containing 6 Neighboring gene phospholipase A2 group VII Neighboring gene ankyrin repeat domain 66 Neighboring gene adhesion G protein-coupled receptor F5 Neighboring gene ADGRF5 antisense RNA 1 Neighboring gene uncharacterized LOC105375080

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables metalloendopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    meprin A subunit alpha
    Names
    N-benzoyl-L-tyrosyl-P-amino-benzoic acid hydrolase subunit alpha
    PABA peptide hydrolase
    PPH alpha
    bA268F1.1 (meprin A alpha (PABA peptide hydrolase))
    endopeptidase-2
    meprin A, alpha (PABA peptide hydrolase)
    NP_005579.2
    XP_011512930.1
    XP_011512931.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_005588.3NP_005579.2  meprin A subunit alpha precursor

      See identical proteins and their annotated locations for NP_005579.2

      Status: VALIDATED

      Source sequence(s)
      AF478685, DA432559
      Consensus CDS
      CCDS4918.1
      UniProtKB/Swiss-Prot
      Q16819
      Related
      ENSP00000230588.4, ENST00000230588.9
      Conserved Domains (6) summary
      cd06263
      Location:269431
      MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...
      smart00137
      Location:264431
      MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
      cd00054
      Location:672710
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cd03783
      Location:431594
      MATH_Meprin_Alpha; Meprin family, Alpha subunit, MATH domain; Meprins are multidomain extracellular metalloproteases capable of cleaving growth factors, cytokines, extracellular matrix proteins, and biologically active peptides. They are composed of two related subunits, ...
      cd04282
      Location:30259
      ZnMc_meprin; Zinc-dependent metalloprotease, meprin_like subfamily. Meprins are membrane-bound or secreted extracellular proteases, which cleave a variety of targets, including peptides such as parathyroid hormone, gastrin, and cholecystokinin, cytokines such as ...
      pfam01400
      Location:73261
      Astacin; Astacin (Peptidase family M12A)

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

      Range
      46793384..46845987
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011514628.1XP_011512930.1  meprin A subunit alpha isoform X1

      See identical proteins and their annotated locations for XP_011512930.1

      UniProtKB/TrEMBL
      B7ZL91
      Related
      ENSP00000480465.1, ENST00000611727.2
      Conserved Domains (6) summary
      cd06263
      Location:297459
      MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...
      smart00137
      Location:292459
      MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
      cd00054
      Location:700738
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cd03783
      Location:459622
      MATH_Meprin_Alpha; Meprin family, Alpha subunit, MATH domain; Meprins are multidomain extracellular metalloproteases capable of cleaving growth factors, cytokines, extracellular matrix proteins, and biologically active peptides. They are composed of two related subunits, ...
      cd04282
      Location:58287
      ZnMc_meprin; Zinc-dependent metalloprotease, meprin_like subfamily. Meprins are membrane-bound or secreted extracellular proteases, which cleave a variety of targets, including peptides such as parathyroid hormone, gastrin, and cholecystokinin, cytokines such as ...
      pfam01400
      Location:101289
      Astacin; Astacin (Peptidase family M12A)
    2. XM_011514629.2XP_011512931.1  meprin A subunit alpha isoform X2

      Conserved Domains (6) summary
      cd06263
      Location:269431
      MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...
      smart00137
      Location:264431
      MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
      cd03783
      Location:431594
      MATH_Meprin_Alpha; Meprin family, Alpha subunit, MATH domain; Meprins are multidomain extracellular metalloproteases capable of cleaving growth factors, cytokines, extracellular matrix proteins, and biologically active peptides. They are composed of two related subunits, ...
      cd04282
      Location:30259
      ZnMc_meprin; Zinc-dependent metalloprotease, meprin_like subfamily. Meprins are membrane-bound or secreted extracellular proteases, which cleave a variety of targets, including peptides such as parathyroid hormone, gastrin, and cholecystokinin, cytokines such as ...
      pfam00008
      Location:674695
      EGF; EGF-like domain
      pfam01400
      Location:73261
      Astacin; Astacin (Peptidase family M12A)
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