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    MEOX2 mesenchyme homeobox 2 [ Homo sapiens (human) ]

    Gene ID: 4223, updated on 18-May-2023

    Summary

    Official Symbol
    MEOX2provided by HGNC
    Official Full Name
    mesenchyme homeobox 2provided by HGNC
    Primary source
    HGNC:HGNC:7014
    See related
    Ensembl:ENSG00000106511 MIM:600535; AllianceGenome:HGNC:7014
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    GAX; MOX2
    Summary
    This gene encodes a member of a subfamily of non-clustered, diverged, antennapedia-like homeobox-containing genes. The encoded protein may play a role in the regulation of vertebrate limb myogenesis. Mutations in the related mouse protein may be associated with craniofacial and/or skeletal abnormalities, in addition to neurovascular dysfunction observed in Alzheimer's disease. [provided by RefSeq, Jul 2008]
    Expression
    Biased expression in placenta (RPKM 25.8), fat (RPKM 23.2) and 13 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See MEOX2 in Genome Data Viewer
    Location:
    7p21.2
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2023_03 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (15611212..15686683, complement)
    RS_2023_03 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (15744456..15819945, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (15650837..15726308, complement)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:15638304-15638834 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:15638835-15639363 Neighboring gene uncharacterized LOC105375166 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:15724672-15725504 Neighboring gene long intergenic non-protein coding RNA 2587 Neighboring gene ribosomal protein L36a pseudogene 26

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    involved_in angiogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in limb development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of cell migration involved in sprouting angiogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in roof of mouth development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in skeletal muscle tissue development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in somite development IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in somite specification IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    part_of chromatin ISA
    Inferred from Sequence Alignment
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nuclear speck IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    homeobox protein MOX-2
    Names
    growth arrest-specific homeobox

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_032988.1 RefSeqGene

      Range
      5001..80472
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_704

    mRNA and Protein(s)

    1. NM_005924.5NP_005915.2  homeobox protein MOX-2

      See identical proteins and their annotated locations for NP_005915.2

      Status: REVIEWED

      Source sequence(s)
      BC017021, BQ025060, DA586635
      Consensus CDS
      CCDS34605.1
      UniProtKB/Swiss-Prot
      P50222, Q9UPL6
      Related
      ENSP00000262041.5, ENST00000262041.6
      Conserved Domains (2) summary
      COG5576
      Location:160284
      COG5576; Homeodomain-containing transcription factor [Transcription]
      pfam00046
      Location:191243
      Homeobox; Homeobox domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_03

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

      Range
      15611212..15686683 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060931.1 Alternate T2T-CHM13v2.0

      Range
      15744456..15819945 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)