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    MEOX1 mesenchyme homeobox 1 [ Homo sapiens (human) ]

    Gene ID: 4222, updated on 17-Jun-2024

    Summary

    Official Symbol
    MEOX1provided by HGNC
    Official Full Name
    mesenchyme homeobox 1provided by HGNC
    Primary source
    HGNC:HGNC:7013
    See related
    Ensembl:ENSG00000005102 MIM:600147; AllianceGenome:HGNC:7013
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    KFS2; MOX1
    Summary
    This gene encodes a member of a subfamily of non-clustered, diverged, antennapedia-like homeobox-containing genes. The encoded protein may play a role in the molecular signaling network regulating somite development. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
    Expression
    Biased expression in fat (RPKM 15.6), heart (RPKM 8.2) and 11 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See MEOX1 in Genome Data Viewer
    Location:
    17q21.31
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (43640389..43661922, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (44492923..44514459, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (41717757..41739290, complement)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene DEAH-box helicase 8 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:41605963-41606504 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:41617770-41618270 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:41622297-41623074 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:41623075-41623852 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8560 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12244 Neighboring gene ETS variant transcription factor 4 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:41632016-41632516 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12245 Neighboring gene Sharpr-MPRA regulatory region 2376 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:41656377-41656994 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:41669551-41670050 Neighboring gene uncharacterized LOC124904008 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:41705361-41705862 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:41729461-41729960 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:41738043-41738584 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:41743014-41743539 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:41745859-41746358 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:41746933-41747456 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:41747457-41747978 Neighboring gene long intergenic non-protein coding RNA 2594 Neighboring gene uncharacterized LOC107985085 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:41754903-41755667 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:41767960-41768460 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:41768461-41768961 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12248 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:41779239-41780108 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8562 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8563 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr17:41795928-41796532 Neighboring gene Wolf-Hirschhorn syndrome candidate 1-like 2, pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription activator activity, RNA polymerase II-specific IEA
    Inferred from Electronic Annotation
    more info
     
    enables DNA-binding transcription factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables DNA-binding transcription factor activity, RNA polymerase II-specific ISA
    Inferred from Sequence Alignment
    more info
     
    enables HMG box domain binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables chromatin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables sequence-specific DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables sequence-specific double-stranded DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in hematopoietic stem cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in sclerotome development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in somite development IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in somite development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in somite specification IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    part_of chromatin ISA
    Inferred from Sequence Alignment
    more info
     
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_032987.1 RefSeqGene

      Range
      4973..26506
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_708

    mRNA and Protein(s)

    1. NM_001040002.2NP_001035091.1  homeobox protein MOX-1 isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and coding region (compared to variant 1), resulting in a protein that maintains the reading frame but is shorter at the N- terminus, compared to isoform 1.
      Source sequence(s)
      AC004149, AW410297, BE898972, BQ003431, BQ028272, BX284090, U10492
      Consensus CDS
      CCDS42343.1
      UniProtKB/Swiss-Prot
      P50221
      Related
      ENSP00000377271.2, ENST00000393661.2
      Conserved Domains (1) summary
      pfam00046
      Location:60112
      Homeobox; Homeobox domain
    2. NM_004527.4NP_004518.1  homeobox protein MOX-1 isoform 1

      See identical proteins and their annotated locations for NP_004518.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC004149, BG677020, BQ028272, U10492
      Consensus CDS
      CCDS11466.1
      UniProtKB/Swiss-Prot
      A8K524, A8MWF9, P50221, Q15069
      Related
      ENSP00000321684.4, ENST00000318579.9
      Conserved Domains (1) summary
      pfam00046
      Location:175227
      Homeobox; Homeobox domain
    3. NM_013999.4NP_054705.1  homeobox protein MOX-1 isoform 2

      See identical proteins and their annotated locations for NP_054705.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an exon in the coding region that results in a frameshift and a premature stop codon compared to variant 1. The encoded isoform (2) is shorter and has a distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AC004149, BG677020, BQ028272, U10493
      Consensus CDS
      CCDS11467.1
      UniProtKB/Swiss-Prot
      P50221
      Related
      ENSP00000449049.2, ENST00000549132.2

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      43640389..43661922 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011524818.3XP_011523120.1  homeobox protein MOX-1 isoform X1

      Conserved Domains (1) summary
      pfam00046
      Location:175216
      Homeobox; Homeobox domain

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      44492923..44514459 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054316158.1XP_054172133.1  homeobox protein MOX-1 isoform X1