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    MEIS1 Meis homeobox 1 [ Homo sapiens (human) ]

    Gene ID: 4211, updated on 25-Nov-2021

    Summary

    Official Symbol
    MEIS1provided by HGNC
    Official Full Name
    Meis homeobox 1provided by HGNC
    Primary source
    HGNC:HGNC:7000
    See related
    Ensembl:ENSG00000143995 MIM:601739
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Homeobox genes, of which the most well-characterized category is represented by the HOX genes, play a crucial role in normal development. In addition, several homeoproteins are involved in neoplasia. This gene encodes a homeobox protein belonging to the TALE ('three amino acid loop extension') family of homeodomain-containing proteins. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in endometrium (RPKM 17.9), adrenal (RPKM 12.6) and 21 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See MEIS1 in Genome Data Viewer
    Location:
    2p14
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    109.20211119 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (66435125..66573869)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (66662257..66801001)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 4056 Neighboring gene long intergenic non-protein coding RNA 1873 Neighboring gene MEIS1 5' regulatory region Neighboring gene MEIS1 antisense RNA 3 Neighboring gene E2 enhancer in MEIS1 Neighboring gene HHc2:066588 enhancer in MEIS1 Neighboring gene MEIS1 antisense RNA 2 Neighboring gene E5 enhancer in MEIS1 Neighboring gene HHc2:066628 enhancer in MEIS1 Neighboring gene E7 enhancer in MEIS1 Neighboring gene HCNR606 enhancer in MEIS1 Neighboring gene HHc2:066650 enhancer in MEIS1 Neighboring gene HCNR617 enhancer in MEIS1 Neighboring gene HHc2:066659 enhancer in MEIS1 Neighboring gene HHc2:067135 enhancer in MEIS1 Neighboring gene HHc2:067347 enhancer downstream of MEIS1 Neighboring gene long intergenic non-protein coding RNA 1798 Neighboring gene long intergenic non-protein coding RNA 1797

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    Genetic determinants of P wave duration and PR segment.
    GeneReviews: Not available
    Genetic Loci Associated with Circulating Levels of Very Long-Chain Saturated Fatty Acids.
    GeneReviews: Not available
    Genome-wide association studies of the PR interval in African Americans.
    GeneReviews: Not available
    Genome-wide association study identifies novel restless legs syndrome susceptibility loci on 2p14 and 16q12.1.
    GeneReviews: Not available
    Genome-wide association study of PR interval.
    GeneReviews: Not available
    Genome-wide association study of restless legs syndrome identifies common variants in three genomic regions.
    GeneReviews: Not available
    Genome-wide diet-gene interaction analyses for risk of colorectal cancer.
    GeneReviews: Not available
    Novel loci associated with PR interval in a genome-wide association study of 10 African American cohorts.
    GeneReviews: Not available

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC43380

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    involved_in angiogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in animal organ morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in brain development IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in definitive hemopoiesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in embryonic pattern specification IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in eye development IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in hemopoiesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in lens morphogenesis in camera-type eye IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in locomotory behavior IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in megakaryocyte development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of myeloid cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of neuron differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of cell population proliferation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in chromatin ISA
    Inferred from Sequence Alignment
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    part_of transcription regulator complex IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    homeobox protein Meis1
    Names
    Meis1, myeloid ecotropic viral integration site 1 homolog
    WUGSC:H_NH0444B04.1
    leukemogenic homolog protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_011467.1 RefSeqGene

      Range
      4726..143470
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_002398.3NP_002389.1  homeobox protein Meis1

      See identical proteins and their annotated locations for NP_002389.1

      Status: REVIEWED

      Source sequence(s)
      AC007392, AC092669, AI203963, AL832770, BC043503, CB854199, U85707
      Consensus CDS
      CCDS46309.1
      UniProtKB/Swiss-Prot
      O00470
      Related
      ENSP00000272369.8, ENST00000272369.14
      Conserved Domains (2) summary
      pfam05920
      Location:290329
      Homeobox_KN; Homeobox KN domain
      pfam16493
      Location:108192
      Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

      Range
      66435125..66573869
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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