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    SMCP sperm mitochondria associated cysteine rich protein [ Homo sapiens (human) ]

    Gene ID: 4184, updated on 7-Apr-2024

    Summary

    Official Symbol
    SMCPprovided by HGNC
    Official Full Name
    sperm mitochondria associated cysteine rich proteinprovided by HGNC
    Primary source
    HGNC:HGNC:6962
    See related
    Ensembl:ENSG00000163206 MIM:601148; AllianceGenome:HGNC:6962
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MCS; MCSP; HSMCSGEN1
    Summary
    Sperm mitochondria differ in morphology and subcellular localization from those of somatic cells. They are elongated, flattened, and arranged circumferentially to form a helical coiled sheath in the midpiece of the sperm flagellum. The protein encoded by this gene localizes to the capsule associated with the mitochondrial outer membranes and is thought to function in the organization and stabilization of the helical structure of the sperm's mitochondrial sheath. [provided by RefSeq, Jul 2008]
    Expression
    Restricted expression toward testis (RPKM 221.5) See more
    Orthologs
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    Genomic context

    See SMCP in Genome Data Viewer
    Location:
    1q21.3
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (152878322..152885047)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (152014877..152021694)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (152850798..152857523)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105371444 Neighboring gene uncharacterized LOC105371445 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1733 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1734 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1735 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1736 Neighboring gene IVL promoter region Neighboring gene involucrin Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1335 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1336 Neighboring gene long intergenic non-protein coding RNA 1527 Neighboring gene small proline rich protein 5

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC26305, MGC26519

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in flagellated sperm motility ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in penetration of zona pellucida ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in mitochondrial membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    sperm mitochondrial-associated cysteine-rich protein
    Names
    testicular tissue protein Li 119
    testicular tissue protein Li 161

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_030663.3NP_109588.2  sperm mitochondrial-associated cysteine-rich protein

      See identical proteins and their annotated locations for NP_109588.2

      Status: REVIEWED

      Source sequence(s)
      BC014593
      Consensus CDS
      CCDS1029.1
      UniProtKB/Swiss-Prot
      P49901, Q96A42
      UniProtKB/TrEMBL
      Q5T7P5
      Related
      ENSP00000357754.3, ENST00000368765.4

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      152878322..152885047
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      152014877..152021694
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)