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    MCM7 minichromosome maintenance complex component 7 [ Homo sapiens (human) ]

    Gene ID: 4176, updated on 8-Jan-2023

    Summary

    Official Symbol
    MCM7provided by HGNC
    Official Full Name
    minichromosome maintenance complex component 7provided by HGNC
    Primary source
    HGNC:HGNC:6950
    See related
    Ensembl:ENSG00000166508 MIM:600592; AllianceGenome:HGNC:6950
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MCM2; CDC47; P85MCM; P1CDC47; PNAS146; PPP1R104; P1.1-MCM3
    Summary
    The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 4 and 6 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. Cyclin D1-dependent kinase, CDK4, is found to associate with this protein, and may regulate the binding of this protein with the tumorsuppressor protein RB1/RB. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in bone marrow (RPKM 53.3), lymph node (RPKM 33.2) and 24 other tissues See more
    Orthologs
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    Genomic context

    See MCM7 in Genome Data Viewer
    Location:
    7q22.1
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    110 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (100092728..100101397, complement)
    110 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (101332574..101341242, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (99690351..99699020, complement)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 7718 Neighboring gene zinc finger protein 3 Neighboring gene Sharpr-MPRA regulatory region 1952 Neighboring gene COP9 signalosome subunit 6 Neighboring gene microRNA 106b Neighboring gene microRNA 25 Neighboring gene microRNA 93 Neighboring gene adaptor related protein complex 4 subunit mu 1 Neighboring gene TATA-box binding protein associated factor 6 Neighboring gene canopy FGF signaling regulator 4 Neighboring gene metallo-beta-lactamase domain containing 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env Tandem affinity purification and mass spectrometry analysis identify minichromosome maintenance complex component 7 isoform 1 (MCM7), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Gag-Pol gag-pol Tandem affinity purification and mass spectrometry analysis identify minichromosome maintenance complex component 7 isoform 1 (MCM7), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Nef nef Tandem affinity purification and mass spectrometry analysis identify minichromosome maintenance complex component 7 isoform 1 (MCM7), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Pol gag-pol HIV-1 Pol is identified to have a physical interaction with minichromosome maintenance complex component 7 (MCM7) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed
    Pr55(Gag) gag Tandem affinity purification and mass spectrometry analysis identify minichromosome maintenance complex component 7 isoform 1 (MCM7), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Tat tat Expression of HIV-1 Tat upregulates the abundance of minichromosome maintenance complex component 7 (MCM7) in the nucleoli of Jurkat T-cells PubMed
    tat Interaction of HIV-1 Tat with MCM7 in T-cells is identified by a proteomic strategy based on affinity chromatography PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
     
    contributes_to DNA binding TAS
    Traceable Author Statement
    more info
    PubMed 
    contributes_to DNA helicase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    contributes_to single-stranded DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    contributes_to single-stranded DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    contributes_to single-stranded DNA helicase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in DNA replication TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in DNA replication initiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in DNA strand elongation involved in DNA replication IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in DNA unwinding involved in DNA replication IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in DNA unwinding involved in DNA replication IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cell population proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to DNA damage stimulus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cellular response to epidermal growth factor stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to organic substance IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to xenobiotic stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in double-strand break repair via break-induced replication IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in regulation of DNA-templated DNA replication initiation NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in regulation of phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of CMG complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    part_of CMG complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    part_of MCM complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of MCM complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of MCM complex IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    part_of MCM complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    located_in chromatin TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in chromosome, telomeric region HDA PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    located_in membrane HDA PubMed 
    NOT located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    DNA replication licensing factor MCM7
    Names
    CDC47 homolog
    homolog of S. cerevisiae Cdc47
    minichromosome maintenance deficient 7
    protein phosphatase 1, regulatory subunit 104
    NP_001265524.1
    NP_005907.3
    NP_877577.1
    XP_005250405.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001278595.2NP_001265524.1  DNA replication licensing factor MCM7 isoform 2

      See identical proteins and their annotated locations for NP_001265524.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) contains an additional internal segment, which results in translation initiation from an in-frame downstream AUG compared to variant 1. The resulting isoform (2) has a shorter N-terminus compared to isoform 1. Variants 2 and 3 encode the same isoform.
      Source sequence(s)
      AC073842
      Consensus CDS
      CCDS5684.1
      UniProtKB/Swiss-Prot
      P33993
      UniProtKB/TrEMBL
      C6EMX8
      Related
      ENSP00000483795.1, ENST00000621318.4
      Conserved Domains (2) summary
      smart00350
      Location:1465
      MCM; minichromosome maintenance proteins
      cl21455
      Location:200339
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    2. NM_005916.5NP_005907.3  DNA replication licensing factor MCM7 isoform 1

      See identical proteins and their annotated locations for NP_005907.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AC073842
      Consensus CDS
      CCDS5683.1
      UniProtKB/Swiss-Prot
      P33993, Q96GL1
      UniProtKB/TrEMBL
      A0A0S2Z4A5, C6EMX8
      Related
      ENSP00000307288.5, ENST00000303887.10
      Conserved Domains (2) summary
      smart00350
      Location:145641
      MCM; minichromosome maintenance proteins
      pfam14551
      Location:1093
      MCM_N; MCM N-terminal domain
    3. NM_182776.3NP_877577.1  DNA replication licensing factor MCM7 isoform 2

      See identical proteins and their annotated locations for NP_877577.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs at the 5' end, contains an additional internal segment, and initiates translation from an in-frame downstream AUG compared to variant 1. The resulting isoform (2) has a shorter N-terminus compared to isoform 1. Variants 2 and 3 encode the same isoform.
      Source sequence(s)
      AK055379, AK226175
      Consensus CDS
      CCDS5684.1
      UniProtKB/Swiss-Prot
      P33993
      Related
      ENSP00000346171.3, ENST00000354230.7
      Conserved Domains (2) summary
      smart00350
      Location:1465
      MCM; minichromosome maintenance proteins
      cl21455
      Location:200339
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

      Range
      100092728..100101397 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005250348.4XP_005250405.1  DNA replication licensing factor MCM7 isoform X1

      Conserved Domains (3) summary
      smart00350
      Location:38534
      MCM; minichromosome maintenance proteins
      pfam14551
      Location:1158
      MCM_N; MCM N-terminal domain
      cl21455
      Location:269408
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060931.1 Alternate T2T-CHM13v2.0

      Range
      101332574..101341242 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)