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    MCM2 minichromosome maintenance complex component 2 [ Homo sapiens (human) ]

    Gene ID: 4171, updated on 21-Mar-2023

    Summary

    Official Symbol
    MCM2provided by HGNC
    Official Full Name
    minichromosome maintenance complex component 2provided by HGNC
    Primary source
    HGNC:HGNC:6944
    See related
    Ensembl:ENSG00000073111 MIM:116945; AllianceGenome:HGNC:6944
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    BM28; CCNL1; CDCL1; cdc19; DFNA70; D3S3194; MITOTIN
    Summary
    The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein forms a complex with MCM4, 6, and 7, and has been shown to regulate the helicase activity of the complex. This protein is phosphorylated, and thus regulated by, protein kinases CDC2 and CDC7. Multiple alternatively spliced transcript variants have been found, but the full-length nature of some variants has not been defined. [provided by RefSeq, Oct 2012]
    Expression
    Broad expression in bone marrow (RPKM 27.3), lymph node (RPKM 14.9) and 23 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See MCM2 in Genome Data Viewer
    Location:
    3q21.3
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2023_03 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (127598411..127622436)
    RS_2023_03 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (130333077..130357098)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (127317254..127341279)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene transmembrane protein adipocyte associated 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:127307841-127308518 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:127308519-127309195 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:127316932-127317889 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:127335678-127336178 Neighboring gene uncharacterized LOC107986126 Neighboring gene podocalyxin like 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:127357688-127358188 Neighboring gene ankyrin repeat and BTB domain containing 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat HIV-1 Tat upregulates the expression of minichromosome maintenance complex component 2 (MCM2) in Jurkat cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • KIAA0030, MGC10606

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    contributes_to 3'-5' DNA helicase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables DNA binding TAS
    Traceable Author Statement
    more info
    PubMed 
    enables DNA replication origin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables enzyme binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables single-stranded DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    contributes_to single-stranded DNA helicase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of CMG complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    part_of CMG complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    part_of MCM complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of MCM complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of MCM complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    located_in chromatin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in chromosome, telomeric region HDA PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of nuclear origin of replication recognition complex IEA
    Inferred from Electronic Annotation
    more info
     
    NOT located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    DNA replication licensing factor MCM2
    Names
    cell devision cycle-like 1
    cyclin-like 1
    minichromosome maintenance deficient 2 (mitotin)
    minichromosome maintenance protein 2 homolog
    nuclear protein BM28
    NP_004517.2
    XP_024309299.1
    XP_054202535.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_050771.1 RefSeqGene

      Range
      5055..29080
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_004526.4NP_004517.2  DNA replication licensing factor MCM2

      See identical proteins and their annotated locations for NP_004517.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes a functional protein.
      Source sequence(s)
      BC007938, DB100427
      Consensus CDS
      CCDS3043.1
      UniProtKB/Swiss-Prot
      P49736, Q9BRM7
      Related
      ENSP00000265056.7, ENST00000265056.12
      Conserved Domains (3) summary
      smart00350
      Location:291803
      MCM; minichromosome maintenance proteins
      pfam12619
      Location:73182
      MCM2_N; Mini-chromosome maintenance protein 2
      pfam14551
      Location:197286
      MCM_N; MCM N-terminal domain

    RNA

    1. NR_073375.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) has an additional segment in the 5' region, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AK299934, BC000300
      Related
      ENST00000474964.5

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_03

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

      Range
      127598411..127622436
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024453531.2XP_024309299.1  DNA replication licensing factor MCM2 isoform X1

      Conserved Domains (3) summary
      smart00350
      Location:282794
      MCM; minichromosome maintenance proteins
      pfam12619
      Location:64173
      MCM2_N; Mini-chromosome maintenance protein 2
      pfam14551
      Location:190278
      MCM_N; MCM N-terminal domain

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060927.1 Alternate T2T-CHM13v2.0

      Range
      130333077..130357098
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054346560.1XP_054202535.1  DNA replication licensing factor MCM2 isoform X1