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    MCAM melanoma cell adhesion molecule [ Homo sapiens (human) ]

    Gene ID: 4162, updated on 18-Jun-2019

    Summary

    Official Symbol
    MCAMprovided by HGNC
    Official Full Name
    melanoma cell adhesion moleculeprovided by HGNC
    Primary source
    HGNC:HGNC:6934
    See related
    Ensembl:ENSG00000076706 MIM:155735
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CD146; MUC18; HEMCAM; METCAM; MelCAM
    Expression
    Broad expression in fat (RPKM 237.1), placenta (RPKM 102.0) and 17 other tissues See more
    Orthologs

    Genomic context

    See MCAM in Genome Data Viewer
    Location:
    11q23.3
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    109.20190607 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (119305759..119317130, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (119179234..119189087, complement)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene FRA11B repeat instability region Neighboring gene Cbl proto-oncogene Neighboring gene RNA, U6 small nuclear 262, pseudogene Neighboring gene microRNA 6756 Neighboring gene ring finger protein 26 Neighboring gene C1q and TNF related 5 Neighboring gene membrane frizzled-related protein

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    anatomical structure morphogenesis TAS
    Traceable Author Statement
    more info
    PubMed 
    angiogenesis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    glomerular filtration IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    positive regulation of cell migration IEA
    Inferred from Electronic Annotation
    more info
     
    vascular wound healing IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    Component Evidence Code Pubs
    external side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular region HDA PubMed 
    extracellular space IEA
    Inferred from Electronic Annotation
    more info
     
    focal adhesion HDA PubMed 
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane NAS
    Non-traceable Author Statement
    more info
    PubMed 

    General protein information

    Preferred Names
    cell surface glycoprotein MUC18
    Names
    Gicerin
    S-endo 1 endothelial-associated antigen
    cell surface glycoprotein P1H12
    melanoma adhesion molecule
    melanoma-associated antigen A32
    melanoma-associated antigen MUC18

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_006500.3NP_006491.2  cell surface glycoprotein MUC18 precursor

      See identical proteins and their annotated locations for NP_006491.2

      Status: VALIDATED

      Source sequence(s)
      AB209925, AP002956, AU076908, BC056418
      Consensus CDS
      CCDS31690.1
      UniProtKB/Swiss-Prot
      P43121
      UniProtKB/TrEMBL
      A0A024R3I5
      Related
      ENSP00000264036.4, ENST00000264036.6
      Conserved Domains (3) summary
      pfam08205
      Location:139234
      C2-set_2; CD80-like C2-set immunoglobulin domain
      pfam13927
      Location:261321
      Ig_3; Immunoglobulin domain
      cl11960
      Location:450510
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

      Range
      119305759..119317130 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017017762.2XP_016873251.1  cell surface glycoprotein MUC18 isoform X4

    2. XM_017017759.2XP_016873248.1  cell surface glycoprotein MUC18 isoform X1

    3. XM_017017760.2XP_016873249.1  cell surface glycoprotein MUC18 isoform X2

    4. XM_017017761.2XP_016873250.1  cell surface glycoprotein MUC18 isoform X3

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