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    MAGEA12 MAGE family member A12 [ Homo sapiens (human) ]

    Gene ID: 4111, updated on 22-Jun-2021

    Summary

    Official Symbol
    MAGEA12provided by HGNC
    Official Full Name
    MAGE family member A12provided by HGNC
    Primary source
    HGNC:HGNC:6799
    See related
    Ensembl:ENSG00000213401 MIM:300177
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CT1.12; MAGE12
    Summary
    This gene is closely related to several other genes clustered on chromosome X. These genes may be overexpressed in tumors. Multiple alternatively spliced variants encoding the same protein have been identified. [provided by RefSeq, Jun 2014]
    Expression
    Restricted expression toward testis (RPKM 1.8) See more
    Orthologs
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    Genomic context

    See MAGEA12 in Genome Data Viewer
    Location:
    Xq28
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    109.20210514 current GRCh38.p13 (GCF_000001405.39) X NC_000023.11 (152733757..152737669)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (151899293..151903206, complement)

    Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene MAGE family member A2B Neighboring gene chondrosarcoma associated gene 1 Neighboring gene CSAG family member 4 (pseudogene) Neighboring gene MAGE family member A2 Neighboring gene CSAG family member 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables histone deacetylase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables molecular_function ND
    No biological Data available
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
     
    involved_in negative regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    melanoma-associated antigen 12
    Names
    MAGE12F antigen
    cancer/testis antigen 1.12
    cancer/testis antigen family 1, member 12
    melanoma antigen family A, 12
    melanoma antigen family A12

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_015852.2 RefSeqGene

      Range
      4940..8852
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001166386.3NP_001159858.1  melanoma-associated antigen 12

      See identical proteins and their annotated locations for NP_001159858.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 all encode the same protein.
      Source sequence(s)
      AC244102
      Consensus CDS
      CCDS76048.1
      UniProtKB/Swiss-Prot
      P43365
      Related
      ENSP00000377478.3, ENST00000393900.4
      Conserved Domains (2) summary
      pfam01454
      Location:116280
      MAGE; MAGE family
      pfam12440
      Location:594
      MAGE_N; Melanoma associated antigen family N terminal
    2. NM_001166387.4NP_001159859.1  melanoma-associated antigen 12

      See identical proteins and their annotated locations for NP_001159859.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 all encode the same protein.
      Source sequence(s)
      AC244102
      Consensus CDS
      CCDS76048.1
      UniProtKB/Swiss-Prot
      P43365
      Related
      ENSP00000377447.3, ENST00000393869.8
      Conserved Domains (2) summary
      pfam01454
      Location:116280
      MAGE; MAGE family
      pfam12440
      Location:594
      MAGE_N; Melanoma associated antigen family N terminal
    3. NM_005367.7NP_005358.2  melanoma-associated antigen 12

      See identical proteins and their annotated locations for NP_005358.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 all encode the same protein.
      Source sequence(s)
      AC244102
      Consensus CDS
      CCDS76048.1
      UniProtKB/Swiss-Prot
      P43365
      Related
      ENSP00000350592.4, ENST00000357916.8
      Conserved Domains (2) summary
      pfam01454
      Location:116280
      MAGE; MAGE family
      pfam12440
      Location:594
      MAGE_N; Melanoma associated antigen family N terminal

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000023.11 Reference GRCh38.p13 Primary Assembly

      Range
      152733757..152737669
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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