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    MAGEA11 MAGE family member A11 [ Homo sapiens (human) ]

    Gene ID: 4110, updated on 17-Jun-2024

    Summary

    Official Symbol
    MAGEA11provided by HGNC
    Official Full Name
    MAGE family member A11provided by HGNC
    Primary source
    HGNC:HGNC:6798
    See related
    Ensembl:ENSG00000185247 MIM:300344; AllianceGenome:HGNC:6798
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CT1.11; MAGE11; MAGE-11; MAGEA-11
    Summary
    This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
    Expression
    Restricted expression toward testis (RPKM 1.8) See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See MAGEA11 in Genome Data Viewer
    Location:
    Xq28
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (149688193..149717268)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (147951770..147980829, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (148769859..148798928)

    Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene transmembrane protein 185A Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 21044 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 21045 Neighboring gene FRAXF repeat instability region Neighboring gene MAGE family member A11 pseudogene Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chrX:148757169-148757709 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chrX:148808885-148809420 Neighboring gene MAGE family member A10 pseudogene Neighboring gene MAGE family member A11 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC10511

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables histone deacetylase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    located_in nuclear body IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    melanoma-associated antigen 11
    Names
    MAGE-11 antigen
    cancer/testis antigen 1.11
    cancer/testis antigen family 1, member 11
    melanoma antigen family A, 11
    melanoma antigen family A11

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_012803.2 RefSeqGene

      Range
      28869..34077
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001011544.2NP_001011544.1  melanoma-associated antigen 11 isoform b

      See identical proteins and their annotated locations for NP_001011544.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and CDS compared to variant 1. The resulting isoform (b) is shorter and has a distinct N-terminus compared to isoform a.
      Source sequence(s)
      AC244197, AI691089, BC004479, BX337921
      Consensus CDS
      CCDS94721.1
      UniProtKB/TrEMBL
      G5E962
      Related
      ENSP00000328177.4, ENST00000333104.8
      Conserved Domains (2) summary
      pfam01454
      Location:214368
      MAGE; MAGE family
      pfam12440
      Location:86175
      MAGE_N; Melanoma associated antigen family N terminal
    2. NM_005366.5NP_005357.2  melanoma-associated antigen 11 isoform a

      See identical proteins and their annotated locations for NP_005357.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (a).
      Source sequence(s)
      AC244098, AI691089, BC004479, BQ212898
      Consensus CDS
      CCDS48180.1
      UniProtKB/Swiss-Prot
      P43364, Q5ETU4, Q6ZRZ5
      Related
      ENSP00000347358.5, ENST00000355220.6
      Conserved Domains (2) summary
      pfam01454
      Location:243397
      MAGE; MAGE family
      pfam12440
      Location:115204
      MAGE_N; Melanoma associated antigen family N terminal

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

      Range
      149688193..149717268
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047442106.1XP_047298062.1  melanoma-associated antigen 11 isoform X1

      UniProtKB/Swiss-Prot
      P43364, Q5ETU4, Q6ZRZ5
    2. XM_011531164.3XP_011529466.1  melanoma-associated antigen 11 isoform X2

      Conserved Domains (2) summary
      pfam01454
      Location:235389
      MAGE; MAGE family
      pfam12440
      Location:107196
      MAGE_N; Melanoma associated antigen family N terminal

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060947.1 Alternate T2T-CHM13v2.0

      Range
      147951770..147980829 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054327064.1XP_054183039.1  melanoma-associated antigen 11 isoform X1

      UniProtKB/Swiss-Prot
      P43364, Q5ETU4, Q6ZRZ5
    2. XM_054327065.1XP_054183040.1  melanoma-associated antigen 11 isoform X3