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    MAGEA3 MAGE family member A3 [ Homo sapiens (human) ]

    Gene ID: 4102, updated on 10-Oct-2024

    Summary

    Official Symbol
    MAGEA3provided by HGNC
    Official Full Name
    MAGE family member A3provided by HGNC
    Primary source
    HGNC:HGNC:6801
    See related
    Ensembl:ENSG00000221867 MIM:300174; AllianceGenome:HGNC:6801
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HIP8; HYPD; CT1.3; MAGE3; MAGEA6
    Summary
    This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita. [provided by RefSeq, Jul 2008]
    Expression
    Restricted expression toward testis (RPKM 4.8) See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See MAGEA3 in Genome Data Viewer
    Location:
    Xq28
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (152698794..152702347)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (150965367..150968920)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (151867272..151870825)

    Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene MAGEA3 divergent transcript Neighboring gene gamma-aminobutyric acid type A receptor subunit theta Neighboring gene MAGE family member A4 pseudogene Neighboring gene uncharacterized LOC124905224 Neighboring gene CSAG family member 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    Knockdown of melanoma antigen family A, 3 (MAGEA3) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General protein information

    Preferred Names
    melanoma-associated antigen 3
    Names
    MAGE-3 antigen
    antigen MZ2-D
    cancer/testis antigen 1.3
    cancer/testis antigen family 1, member 3
    melanoma antigen family A, 3
    melanoma antigen family A3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_013244.2 RefSeqGene

      Range
      5002..8555
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_005362.4NP_005353.1  melanoma-associated antigen 3

      See identical proteins and their annotated locations for NP_005353.1

      Status: REVIEWED

      Source sequence(s)
      AC244102
      Consensus CDS
      CCDS76045.1
      UniProtKB/Swiss-Prot
      P43357, Q6FHI6
      UniProtKB/TrEMBL
      Q53EX0
      Related
      ENSP00000359301.3, ENST00000370278.4
      Conserved Domains (2) summary
      pfam01454
      Location:116280
      MAGE; MAGE family
      pfam12440
      Location:594
      MAGE_N; Melanoma associated antigen family N terminal

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

      Range
      152698794..152702347
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006724818.3XP_006724881.1  melanoma-associated antigen 3 isoform X1

      See identical proteins and their annotated locations for XP_006724881.1

      UniProtKB/Swiss-Prot
      P43357, Q6FHI6
      UniProtKB/TrEMBL
      Q53EX0
      Conserved Domains (2) summary
      pfam01454
      Location:116280
      MAGE; MAGE family
      pfam12440
      Location:594
      MAGE_N; Melanoma associated antigen family N terminal
    2. XM_011531160.4XP_011529462.1  melanoma-associated antigen 3 isoform X1

      See identical proteins and their annotated locations for XP_011529462.1

      UniProtKB/Swiss-Prot
      P43357, Q6FHI6
      UniProtKB/TrEMBL
      Q53EX0
      Conserved Domains (2) summary
      pfam01454
      Location:116280
      MAGE; MAGE family
      pfam12440
      Location:594
      MAGE_N; Melanoma associated antigen family N terminal
    3. XM_005274676.4XP_005274733.1  melanoma-associated antigen 3 isoform X1

      See identical proteins and their annotated locations for XP_005274733.1

      UniProtKB/Swiss-Prot
      P43357, Q6FHI6
      UniProtKB/TrEMBL
      Q53EX0
      Related
      ENSP00000473093.1, ENST00000598245.2
      Conserved Domains (2) summary
      pfam01454
      Location:116280
      MAGE; MAGE family
      pfam12440
      Location:594
      MAGE_N; Melanoma associated antigen family N terminal
    4. XM_011531161.2XP_011529463.1  melanoma-associated antigen 3 isoform X1

      See identical proteins and their annotated locations for XP_011529463.1

      UniProtKB/Swiss-Prot
      P43357, Q6FHI6
      UniProtKB/TrEMBL
      Q53EX0
      Conserved Domains (2) summary
      pfam01454
      Location:116280
      MAGE; MAGE family
      pfam12440
      Location:594
      MAGE_N; Melanoma associated antigen family N terminal

    Reference GRCh38.p14 PATCHES

    Genomic

    1. NW_025791818.1 Reference GRCh38.p14 PATCHES

      Range
      381298..384860 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054333339.1XP_054189314.1  melanoma-associated antigen 3 isoform X1

      UniProtKB/Swiss-Prot
      P43357, Q6FHI6
    2. XM_054333338.1XP_054189313.1  melanoma-associated antigen 3 isoform X1

      UniProtKB/Swiss-Prot
      P43357, Q6FHI6
    3. XM_054333337.1XP_054189312.1  melanoma-associated antigen 3 isoform X1

      UniProtKB/Swiss-Prot
      P43357, Q6FHI6
    4. XM_054333340.1XP_054189315.1  melanoma-associated antigen 3 isoform X1

      UniProtKB/Swiss-Prot
      P43357, Q6FHI6

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060947.1 Alternate T2T-CHM13v2.0

      Range
      150965367..150968920
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054327057.1XP_054183032.1  melanoma-associated antigen 3 isoform X1

      UniProtKB/Swiss-Prot
      A8IF93, P43360, Q6NW44