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    ANKHD1-EIF4EBP3 ANKHD1-EIF4EBP3 readthrough [ Homo sapiens (human) ]

    Gene ID: 404734, updated on 15-Jun-2019

    Summary

    Official Symbol
    ANKHD1-EIF4EBP3provided by HGNC
    Official Full Name
    ANKHD1-EIF4EBP3 readthroughprovided by HGNC
    Primary source
    HGNC:HGNC:33530
    See related
    Ensembl:ENSG00000254996
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MASK-BP3; MASK-BP3ARF
    Summary
    The ANKHD1-EIF4EBP3 mRNA is an infrequent but naturally occurring readthrough transcript of the neighboring ANKHD1 and EIF4EBP3 genes. This readthrough transcript encodes a protein composed mostly of the multiple ankyrin repeats, single KH-domain protein, with its C-terminus encoded in a different reading frame from the shared portion of the EIF4EBP3 gene. The significance of this readthrough mRNA and the function of its protein product have not yet been determined. [provided by RefSeq, Nov 2009]
    Expression
    Ubiquitous expression in thyroid (RPKM 19.9), skin (RPKM 16.1) and 25 other tissues See more
    Orthologs

    Genomic context

    See ANKHD1-EIF4EBP3 in Genome Data Viewer
    Location:
    5q31.3
    Exon count:
    36
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 5 NC_000005.10 (140401814..140549578)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (139781399..139929163)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene solute carrier family 4 member 9 Neighboring gene RNA, U4 small nuclear 14, pseudogene Neighboring gene ankyrin repeat and KH domain containing 1 Neighboring gene eukaryotic translation initiation factor 4E binding protein 3 Neighboring gene steroid receptor RNA activator 1 Neighboring gene microRNA 6831 Neighboring gene amyloid beta precursor protein binding family B member 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    General protein information

    Preferred Names
    ANKHD1-EIF4EBP3 protein
    Names
    MASK-4E-BP3 alternate reading frame

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_020690.5NP_065741.3  ANKHD1-EIF4EBP3 protein

      See identical proteins and their annotated locations for NP_065741.3

      Status: REVIEWED

      Source sequence(s)
      AC008438, AC011399, AF521883
      Consensus CDS
      CCDS4224.1
      UniProtKB/Swiss-Prot
      Q8IWZ3
      Related
      ENSP00000432016.1, ENST00000532219.5
      Conserved Domains (7) summary
      cd00105
      Location:16971759
      KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
      cd00204
      Location:367491
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam05672
      Location:780865
      MAP7; MAP7 (E-MAP-115) family
      pfam12796
      Location:276365
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:374425
      Ank_4; Ankyrin repeats (many copies)
      sd00045
      Location:406435
      ANK; ANK repeat [structural motif]
      cl09111
      Location:814852
      Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000005.10 Reference GRCh38.p13 Primary Assembly

      Range
      140401814..140549578
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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