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    PAIP2B poly(A) binding protein interacting protein 2B [ Homo sapiens (human) ]

    Gene ID: 400961, updated on 17-Jun-2019

    Summary

    Official Symbol
    PAIP2Bprovided by HGNC
    Official Full Name
    poly(A) binding protein interacting protein 2Bprovided by HGNC
    Primary source
    HGNC:HGNC:29200
    See related
    Ensembl:ENSG00000124374 MIM:611018
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Most mRNAs, except for histones, contain a 3-prime poly(A) tail. Poly(A)-binding protein (PABP; see MIM 604679) enhances translation by circularizing mRNA through its interaction with the translation initiation factor EIF4G1 (MIM 600495) and the poly(A) tail. Various PABP-binding proteins regulate PABP activity, including PAIP1 (MIM 605184), a translational stimulator, and PAIP2A (MIM 605604) and PAIP2B, translational inhibitors (Derry et al., 2006 [PubMed 17381337]).[supplied by OMIM, Mar 2008]
    Expression
    Broad expression in brain (RPKM 9.7), thyroid (RPKM 9.0) and 23 other tissues See more
    Orthologs

    Genomic context

    See PAIP2B in Genome Data Viewer
    Location:
    2p13.3
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    109.20190607 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (71182738..71227110, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (71409868..71454233, complement)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene M-phase phosphoprotein 10 Neighboring gene methylmalonyl-CoA epimerase Neighboring gene uncharacterized LOC105374797 Neighboring gene Sharpr-MPRA regulatory region 7735 Neighboring gene zinc finger protein 638

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • KIAA1155

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    translation repressor activity, mRNA regulatory element binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    negative regulation of translational initiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasm IC
    Inferred by Curator
    more info
    PubMed 

    General protein information

    Preferred Names
    polyadenylate-binding protein-interacting protein 2B
    Names
    PABP-interacting protein 2B
    PAIP-2B

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_020459.1NP_065192.1  polyadenylate-binding protein-interacting protein 2B

      See identical proteins and their annotated locations for NP_065192.1

      Status: VALIDATED

      Source sequence(s)
      AB032981, AC007881, DA247526, DA346299
      Consensus CDS
      CCDS46322.1
      UniProtKB/Swiss-Prot
      Q9ULR5
      Related
      ENSP00000244221.8, ENST00000244221.9
      Conserved Domains (1) summary
      pfam07145
      Location:106120
      PAM2; Ataxin-2 C-terminal region

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

      Range
      71182738..71227110 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011532843.2XP_011531145.1  polyadenylate-binding protein-interacting protein 2B isoform X2

      See identical proteins and their annotated locations for XP_011531145.1

      UniProtKB/Swiss-Prot
      Q9ULR5
      Conserved Domains (1) summary
      pfam07145
      Location:106120
      PAM2; Ataxin-2 C-terminal region
    2. XM_005264311.4XP_005264368.1  polyadenylate-binding protein-interacting protein 2B isoform X2

      See identical proteins and their annotated locations for XP_005264368.1

      UniProtKB/Swiss-Prot
      Q9ULR5
      Conserved Domains (1) summary
      pfam07145
      Location:106120
      PAM2; Ataxin-2 C-terminal region
    3. XM_011532842.3XP_011531144.1  polyadenylate-binding protein-interacting protein 2B isoform X1

      See identical proteins and their annotated locations for XP_011531144.1

      Conserved Domains (1) summary
      pfam07145
      Location:127141
      PAM2; Ataxin-2 C-terminal region
    4. XM_005264310.4XP_005264367.1  polyadenylate-binding protein-interacting protein 2B isoform X2

      See identical proteins and their annotated locations for XP_005264367.1

      UniProtKB/Swiss-Prot
      Q9ULR5
      Conserved Domains (1) summary
      pfam07145
      Location:106120
      PAM2; Ataxin-2 C-terminal region
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