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    CD58 CD58 molecule [ Sus scrofa (pig) ]

    Gene ID: 396702, updated on 26-Jun-2026
    Official Symbol
    CD58provided by VGNC
    Official Full Name
    CD58 moleculeprovided by VGNC
    Primary source
    VGNC:VGNC:86422
    See related
    Ensembl:ENSSSCG00000006738 RGD:14239462
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Sus scrofa
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
    Expression
    Ubiquitous expression in lung (RPKM 27.2), spleen (RPKM 20.2) and 8 other tissues See more
    Orthologs
    all
    Try the new Gene page
    Try the new Transcripts and proteins table
    See CD58 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2026_06 current Sscrofa_HxYL_maternal_Yorkshire_Landrace_v2.0 (GCF_054392235.1) 4 NC_139386.1 (109348489..109402445)
    106 previous assembly Sscrofa11.1 (GCF_000003025.6) 4 NC_010446.5 (104170827..104225029)

    Chromosome 4 - NC_139386.1Genomic Context describing neighboring genes Neighboring gene immunoglobulin superfamily member 3 Neighboring gene uncharacterized LOC146404176 Neighboring gene uncharacterized LOC146404177 Neighboring gene zinc finger protein 296 Neighboring gene uncharacterized LOC146404178 Neighboring gene uncharacterized LOC110260338 Neighboring gene uncharacterized LOC146404179 Neighboring gene ATPase Na+/K+ transporting subunit alpha 1

    Go to nucleotide: Graphics FASTA GenBank

    Related articles in PubMed

    1. A novel monoclonal antibody inhibits the immune response of human cells against porcine cells: identification of a porcine antigen homologous to CD58. Crosby K, et al. Transplantation, 2004 Apr 27. PMID 15114100
    2. Porcine CD58: cDNA cloning and molecular dissection of the porcine CD58-human CD2 interface. Brossay A, et al. Biochem Biophys Res Commun, 2003 Oct 3. PMID 13679072
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. immunoaffinity purification of a cell surface protein of relative molecular mass (Mr)=45,000 containing N-linked carbohydrate chains using a novel monoclonal antibody
      Title: A novel monoclonal antibody inhibits the immune response of human cells against porcine cells: identification of a porcine antigen homologous to CD58.
    Submit: New GeneRIF Correction

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables signaling receptor binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell surface IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Preferred Names
    lymphocyte function-associated antigen 3
    Names
    CD58 antigen

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_213795.1 → NP_998960.1  lymphocyte function-associated antigen 3 precursor

      See identical proteins and their annotated locations for NP_998960.1

      Status: PROVISIONAL

      Source sequence(s)
      AF469666
      UniProtKB/TrEMBL
      Q7YS40, Q8SQB6
      Related
      ENSSSCP00000007188.4, ENSSSCT00000007383.5
      Conserved Domains (2) summary
      cd05741
      Location:39 → 121
      Ig_CEACAM_D1_like; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM) and similar proteins
      smart00410
      Location:30 → 121
      IG_like; Immunoglobulin like

    RefSeqs of Annotated Genomes: GCF_054392235.1-RS_2026_06

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Sscrofa_HxYL_maternal_Yorkshire_Landrace_v2.0

    Genomic

    1. NC_139386.1 Reference Sscrofa_HxYL_maternal_Yorkshire_Landrace_v2.0

      Range
      109348489..109402445
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_085020886.1 → XP_084877012.1  lymphocyte function-associated antigen 3 isoform X1

    RNA

    1. XR_014842849.1 RNA Sequence

    2. XR_014842850.1 RNA Sequence

    3. XR_014842851.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials