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    LGALS4 galectin 4 [ Homo sapiens (human) ]

    Gene ID: 3960, updated on 17-Jun-2019

    Summary

    Official Symbol
    LGALS4provided by HGNC
    Official Full Name
    galectin 4provided by HGNC
    Primary source
    HGNC:HGNC:6565
    See related
    Ensembl:ENSG00000171747 MIM:602518
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    GAL4; L36LBP
    Summary
    The galectins are a family of beta-galactoside-binding proteins implicated in modulating cell-cell and cell-matrix interactions. The expression of this gene is restricted to small intestine, colon, and rectum, and it is underexpressed in colorectal cancer. [provided by RefSeq, Jul 2008]
    Expression
    Biased expression in colon (RPKM 740.5), duodenum (RPKM 465.8) and 4 other tissues See more
    Orthologs

    Genomic context

    See LGALS4 in Genome Data Viewer
    Location:
    19q13.2
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    109.20190607 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (38801671..38813614, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (39292311..39303740, complement)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene galectin 7B Neighboring gene RNA, U6 small nuclear 140, pseudogene Neighboring gene enoyl-CoA hydratase 1 Neighboring gene heterogeneous nuclear ribonucleoprotein L

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    carbohydrate binding IEA
    Inferred from Electronic Annotation
    more info
     
    galactoside binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    cell adhesion TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    collagen-containing extracellular matrix HDA PubMed 
    cytosol TAS
    Traceable Author Statement
    more info
    PubMed 
    extracellular space IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane TAS
    Traceable Author Statement
    more info
    PubMed 

    General protein information

    Preferred Names
    galectin-4
    Names
    L-36 lactose-binding protein
    antigen NY-CO-27
    gal-4
    lactose-binding lectin 4
    lectin, galactoside-binding, soluble, 4

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_006149.4NP_006140.1  galectin-4

      See identical proteins and their annotated locations for NP_006140.1

      Status: REVIEWED

      Source sequence(s)
      AA130458, AK290269
      Consensus CDS
      CCDS12521.1
      UniProtKB/Swiss-Prot
      P56470
      UniProtKB/TrEMBL
      Q6FHZ4
      Related
      ENSP00000302100.3, ENST00000307751.9
      Conserved Domains (2) summary
      smart00908
      Location:199322
      Gal-bind_lectin; Galactoside-binding lectin
      cd00070
      Location:18147
      GLECT; Galectin/galactose-binding lectin. This domain exclusively binds beta-galactosides, such as lactose, and does not require metal ions for activity. GLECT domains occur as homodimers or tandemly repeated domains. They are developmentally regulated and may ...

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

      Range
      38801671..38813614 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011526974.2XP_011525276.1  galectin-4 isoform X2

      See identical proteins and their annotated locations for XP_011525276.1

      Conserved Domains (1) summary
      smart00908
      Location:68191
      Gal-bind_lectin; Galactoside-binding lectin
    2. XM_011526973.2XP_011525275.1  galectin-4 isoform X1

      Conserved Domains (2) summary
      smart00908
      Location:186309
      Gal-bind_lectin; Galactoside-binding lectin
      cd00070
      Location:18147
      GLECT; Galectin/galactose-binding lectin. This domain exclusively binds beta-galactosides, such as lactose, and does not require metal ions for activity. GLECT domains occur as homodimers or tandemly repeated domains. They are developmentally regulated and may ...

    Reference GRCh38.p13 PATCHES

    Genomic

    1. NW_014040929.1 Reference GRCh38.p13 PATCHES

      Range
      211357..222617 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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