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    PINLYP phospholipase A2 inhibitor and LY6/PLAUR domain containing [ Homo sapiens (human) ]

    Gene ID: 390940, updated on 19-Jun-2019

    Summary

    Official Symbol
    PINLYPprovided by HGNC
    Official Full Name
    phospholipase A2 inhibitor and LY6/PLAUR domain containingprovided by HGNC
    Primary source
    HGNC:HGNC:44206
    See related
    Ensembl:ENSG00000234465
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Expression
    Ubiquitous expression in ovary (RPKM 1.9), endometrium (RPKM 1.3) and 25 other tissues See more
    Orthologs

    Genomic context

    See PINLYP in Genome Data Viewer
    Location:
    19q13.31
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    109.20190607 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (43575399..43582104)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (44080952..44086256)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene ETHE1 persulfide dioxygenase Neighboring gene zinc finger protein 575 Neighboring gene X-ray repair cross complementing 1 Neighboring gene immunity related GTPase Q Neighboring gene zinc finger protein 576

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    Related articles in PubMed

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    phospholipase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    negative regulation of catalytic activity IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    extracellular region IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    phospholipase A2 inhibitor and Ly6/PLAUR domain-containing protein

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001193621.2NP_001180550.2  phospholipase A2 inhibitor and Ly6/PLAUR domain-containing protein isoform 1 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer variant and encodes the longer isoform (1).
      Source sequence(s)
      AI298189, AK296854, BC071811, DW009999, L34079
      Consensus CDS
      CCDS74385.1
      Related
      ENSP00000479240.1, ENST00000612042.4
      Conserved Domains (1) summary
      cl10471
      Location:27107
      LU; Ly-6 antigen / uPA receptor -like domain; occurs singly in GPI-linked cell-surface glycoproteins (Ly-6 family,CD59, thymocyte B cell antigen, Sgp-2) or as three-fold repeated domain in urokinase-type plasminogen activator receptor. Topology of these ...
    2. NM_001193622.1NP_001180551.1  phospholipase A2 inhibitor and Ly6/PLAUR domain-containing protein isoform 2

      See identical proteins and their annotated locations for NP_001180551.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) represents use of an alternate promoter and 5' UTR, and uses a downstream start codon, compared to variant 1. The resulting isoform (2) has a shorter N-terminus, compared to isoform 1. Both variants 2 and 3 encode the same protein.
      Source sequence(s)
      AI298189, BC071811
      Consensus CDS
      CCDS58667.1
      UniProtKB/Swiss-Prot
      A6NC86
      Related
      ENSP00000457623.1, ENST00000562255.5
      Conserved Domains (1) summary
      cl10471
      Location:3888
      LU; Ly-6 antigen / uPA receptor -like domain; occurs singly in GPI-linked cell-surface glycoproteins (Ly-6 family,CD59, thymocyte B cell antigen, Sgp-2) or as three-fold repeated domain in urokinase-type plasminogen activator receptor. Topology of these ...
    3. NM_001321124.1NP_001308053.1  phospholipase A2 inhibitor and Ly6/PLAUR domain-containing protein isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) represents use of an alternate promoter and 5' UTR, and uses a downstream start codon, compared to variant 1. The resulting isoform (2) has a shorter N-terminus, compared to isoform 1. Both variants 2 and 3 encode the same protein.
      Source sequence(s)
      AI298189, CN355575, HY005068
      Consensus CDS
      CCDS58667.1
      UniProtKB/Swiss-Prot
      A6NC86
      Related
      ENSP00000457369.1, ENST00000569031.6
      Conserved Domains (1) summary
      cl10471
      Location:3888
      LU; Ly-6 antigen / uPA receptor -like domain; occurs singly in GPI-linked cell-surface glycoproteins (Ly-6 family,CD59, thymocyte B cell antigen, Sgp-2) or as three-fold repeated domain in urokinase-type plasminogen activator receptor. Topology of these ...

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

      Range
      43575399..43582104
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011526971.2XP_011525273.1  phospholipase A2 inhibitor and Ly6/PLAUR domain-containing protein isoform X2

      See identical proteins and their annotated locations for XP_011525273.1

      UniProtKB/Swiss-Prot
      A6NC86
      Conserved Domains (1) summary
      cl10471
      Location:3888
      LU; Ly-6 antigen / uPA receptor -like domain; occurs singly in GPI-linked cell-surface glycoproteins (Ly-6 family,CD59, thymocyte B cell antigen, Sgp-2) or as three-fold repeated domain in urokinase-type plasminogen activator receptor. Topology of these ...
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