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    ZNF793 zinc finger protein 793 [ Homo sapiens (human) ]

    Gene ID: 390927, updated on 5-Mar-2024

    Summary

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    Official Symbol
    ZNF793provided by HGNC
    Official Full Name
    zinc finger protein 793provided by HGNC
    Primary source
    HGNC:HGNC:33115
    See related
    Ensembl:ENSG00000188227 AllianceGenome:HGNC:33115
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Implicated in Barrett's esophagus. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in testis (RPKM 1.6), brain (RPKM 1.5) and 23 other tissues See more
    Orthologs
    all
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    Genomic context

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    Location:
    19q13.12
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (37506428..37543333)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (40307906..40345149)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (37997841..38034235)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14546 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10555 Neighboring gene zinc finger protein 527 Neighboring gene zinc finger protein 569 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14547 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14548 Neighboring gene zinc finger protein 570 Neighboring gene ZNF793 antisense RNA 1 (head to head) Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:37996759-37997550 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:37997551-37998342 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr19:38020876-38021698 Neighboring gene uncharacterized LOC124904708 Neighboring gene ZNF571 antisense RNA 1 Neighboring gene zinc finger protein 540 Neighboring gene MT-ND4 pseudogene 41 Neighboring gene zinc finger protein 571 Neighboring gene MT-ND5 pseudogene 45

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Methylated B3GAT2 and ZNF793 Are Potential Detection Biomarkers for Barrett's Esophagus. Yu M, et al. Cancer Epidemiol Biomarkers Prev, 2015 Dec. PMID 26545406, Free PMC Article
    2. A human skeletal muscle interactome centered on proteins involved in muscular dystrophies: LGMD interactome. Blandin G, et al. Skelet Muscle, 2013 Feb 15. PMID 23414517, Free PMC Article
    3. Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing. Fei T, et al. Proc Natl Acad Sci U S A, 2017 Jun 27. PMID 28611215, Free PMC Article
    4. Cullin 3 Exon 9 Deletion in Familial Hyperkalemic Hypertension Impairs Cullin3-Ring-E3 Ligase (CRL3) Dynamic Regulation and Cycling. Kouranti I, et al. Int J Mol Sci, 2022 May 5. PMID 35563538, Free PMC Article
    5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. Kimura K, et al. Genome Res, 2006 Jan. PMID 16344560, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 793

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001013659.3 → NP_001013681.2  zinc finger protein 793

      See identical proteins and their annotated locations for NP_001013681.2

      Status: VALIDATED

      Source sequence(s)
      AC022148, AK131417, BE219465, BU683546, BX537524, DB180171
      Consensus CDS
      CCDS46062.1
      UniProtKB/Swiss-Prot
      E9PGN4, Q6ZN11, Q7Z3Q9
      Related
      ENSP00000487183.2, ENST00000627814.3
      Conserved Domains (3) summary
      smart00349
      Location:8 → 68
      KRAB; krueppel associated box
      COG5048
      Location:225 → 385
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:229 → 249
      ZF_C2H2; C2H2 Zn finger [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      37506428..37543333
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047438816.1 → XP_047294772.1  zinc finger protein 793 isoform X1

      UniProtKB/Swiss-Prot
      E9PGN4, Q6ZN11, Q7Z3Q9

    2. XM_047438820.1 → XP_047294776.1  zinc finger protein 793 isoform X1

      UniProtKB/Swiss-Prot
      E9PGN4, Q6ZN11, Q7Z3Q9

    3. XM_047438815.1 → XP_047294771.1  zinc finger protein 793 isoform X1

      UniProtKB/Swiss-Prot
      E9PGN4, Q6ZN11, Q7Z3Q9

    4. XM_006723213.4 → XP_006723276.1  zinc finger protein 793 isoform X1

      See identical proteins and their annotated locations for XP_006723276.1

      UniProtKB/Swiss-Prot
      E9PGN4, Q6ZN11, Q7Z3Q9
      Conserved Domains (3) summary
      smart00349
      Location:8 → 68
      KRAB; krueppel associated box
      COG5048
      Location:225 → 385
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:229 → 249
      ZF_C2H2; C2H2 Zn finger [structural motif]

    5. XM_047438822.1 → XP_047294778.1  zinc finger protein 793 isoform X2

    6. XM_047438814.1 → XP_047294770.1  zinc finger protein 793 isoform X1

      UniProtKB/Swiss-Prot
      E9PGN4, Q6ZN11, Q7Z3Q9

    7. XM_047438819.1 → XP_047294775.1  zinc finger protein 793 isoform X1

      UniProtKB/Swiss-Prot
      E9PGN4, Q6ZN11, Q7Z3Q9

    8. XM_047438817.1 → XP_047294773.1  zinc finger protein 793 isoform X1

      UniProtKB/Swiss-Prot
      E9PGN4, Q6ZN11, Q7Z3Q9

    9. XM_047438813.1 → XP_047294769.1  zinc finger protein 793 isoform X1

      UniProtKB/Swiss-Prot
      E9PGN4, Q6ZN11, Q7Z3Q9

    10. XM_047438818.1 → XP_047294774.1  zinc finger protein 793 isoform X1

      UniProtKB/Swiss-Prot
      E9PGN4, Q6ZN11, Q7Z3Q9
      Related
      ENSP00000468605.1, ENST00000587143.5

    11. XM_047438821.1 → XP_047294777.1  zinc finger protein 793 isoform X1

      UniProtKB/Swiss-Prot
      E9PGN4, Q6ZN11, Q7Z3Q9
      Related
      ENSP00000396402.1, ENST00000445217.5

    12. XM_047438823.1 → XP_047294779.1  zinc finger protein 793 isoform X3

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      40307906..40345149
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054320997.1 → XP_054176972.1  zinc finger protein 793 isoform X1

      UniProtKB/Swiss-Prot
      E9PGN4, Q6ZN11, Q7Z3Q9

    2. XM_054320992.1 → XP_054176967.1  zinc finger protein 793 isoform X1

      UniProtKB/Swiss-Prot
      E9PGN4, Q6ZN11, Q7Z3Q9

    3. XM_054320998.1 → XP_054176973.1  zinc finger protein 793 isoform X1

      UniProtKB/Swiss-Prot
      E9PGN4, Q6ZN11, Q7Z3Q9

    4. XM_054320994.1 → XP_054176969.1  zinc finger protein 793 isoform X1

      UniProtKB/Swiss-Prot
      E9PGN4, Q6ZN11, Q7Z3Q9

    5. XM_054320989.1 → XP_054176964.1  zinc finger protein 793 isoform X1

      UniProtKB/Swiss-Prot
      E9PGN4, Q6ZN11, Q7Z3Q9

    6. XM_054320995.1 → XP_054176970.1  zinc finger protein 793 isoform X1

      UniProtKB/Swiss-Prot
      E9PGN4, Q6ZN11, Q7Z3Q9

    7. XM_054320991.1 → XP_054176966.1  zinc finger protein 793 isoform X1

      UniProtKB/Swiss-Prot
      E9PGN4, Q6ZN11, Q7Z3Q9

    8. XM_054320993.1 → XP_054176968.1  zinc finger protein 793 isoform X1

      UniProtKB/Swiss-Prot
      E9PGN4, Q6ZN11, Q7Z3Q9

    9. XM_054320999.1 → XP_054176974.1  zinc finger protein 793 isoform X2

    10. XM_054320990.1 → XP_054176965.1  zinc finger protein 793 isoform X1

      UniProtKB/Swiss-Prot
      E9PGN4, Q6ZN11, Q7Z3Q9

    11. XM_054320996.1 → XP_054176971.1  zinc finger protein 793 isoform X1

      UniProtKB/Swiss-Prot
      E9PGN4, Q6ZN11, Q7Z3Q9

    12. XM_054321000.1 → XP_054176975.1  zinc finger protein 793 isoform X3

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6ZN11.2 GenPept UniProtKB/Swiss-Prot:Q6ZN11

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