Format

Send to:

Choose Destination
    • Showing Current items.

    ARHGEF37 Rho guanine nucleotide exchange factor 37 [ Homo sapiens (human) ]

    Gene ID: 389337, updated on 15-Jun-2019

    Summary

    Official Symbol
    ARHGEF37provided by HGNC
    Official Full Name
    Rho guanine nucleotide exchange factor 37provided by HGNC
    Primary source
    HGNC:HGNC:34430
    See related
    Ensembl:ENSG00000183111
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Expression
    Broad expression in skin (RPKM 21.4), prostate (RPKM 12.5) and 20 other tissues See more
    Orthologs

    Genomic context

    See ARHGEF37 in Genome Data Viewer
    Location:
    5q32
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 5 NC_000005.10 (149552057..149634968)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (148961064..149014531)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene cardiac mesoderm enhancer-associated non-coding RNA Neighboring gene microRNA 145 Neighboring gene casein kinase 1 alpha 1 Neighboring gene ribosomal protein L29 pseudogene 14 Neighboring gene RNA, U6 small nuclear 588, pseudogene Neighboring gene uncharacterized LOC105378224 Neighboring gene RNA, 7SL, cytoplasmic 868, pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Phenotypes

    NHGRI GWAS Catalog

    Description
    Common genetic variation and antidepressant efficacy in major depressive disorder: a meta-analysis of three genome-wide pharmacogenetic studies.
    NHGRI GWA Catalog

    Pathways from BioSystems

    • Cell death signalling via NRAGE, NRIF and NADE, organism-specific biosystem (from REACTOME)
      Cell death signalling via NRAGE, NRIF and NADE, organism-specific biosystemp75NTR is a key regulator of neuronal apoptosis, both during development and after injury. Apoptosis is triggered by binding of either mature neurotrophin or proneurotrophin (proNGF, proBDNF). ProNG...
    • G alpha (12/13) signalling events, organism-specific biosystem (from REACTOME)
      G alpha (12/13) signalling events, organism-specific biosystemThe G12/13 family is probably the least well characterized subtype, partly because G12/13 coupling is difficult to determine when compared with the other subtypes which predominantly rely on assay te...
    • GPCR downstream signaling, organism-specific biosystem (from REACTOME)
      GPCR downstream signaling, organism-specific biosystemG protein-coupled receptors (GPCRs) are classically defined as the receptor, G-protein and downstream effectors, the alpha subunit of the G-protein being the primary signaling molecule. However, it h...
    • NRAGE signals death through JNK, organism-specific biosystem (from REACTOME)
      NRAGE signals death through JNK, organism-specific biosystemOnce bound by either NGF or proNGF, p75NTR interacts with NRAGE, thus leading to phosphorylation and activation of JUN Kinase (JNK). JNK controls apoptosis in two ways: it induces transcription of pr...
    • Rho GTPase cycle, organism-specific biosystem (from REACTOME)
      Rho GTPase cycle, organism-specific biosystemThe cycling of Rho GTPases is tightly controlled by three classes of protein. These are (1) guanine nucleotide dissociation inhibitors or GDIs, which maintain Rho proteins in an inactive state in the...
    • Signal Transduction, organism-specific biosystem (from REACTOME)
      Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
    • Signaling by GPCR, organism-specific biosystem (from REACTOME)
      Signaling by GPCR, organism-specific biosystemG protein-coupled receptors (GPCRs; 7TM receptors; seven transmembrane domain receptors; heptahelical receptors; G protein-linked receptors [GPLR]) are the largest family of transmembrane receptors i...
    • Signaling by Rho GTPases, organism-specific biosystem (from REACTOME)
      Signaling by Rho GTPases, organism-specific biosystemThe Rho family of small guanine nucleotide binding proteins is one of five generally recognized branches of the Ras superfamily. Like most Ras superfamily members, typical Rho proteins function as bi...
    • Signalling by NGF, organism-specific biosystem (from REACTOME)
      Signalling by NGF, organism-specific biosystemNeurotrophins (NGF, BDNF, NT-3, NT-4/5) play pivotal roles in survival, differentiation, and plasticity of neurons in the peripheral and central nervous system. They are produced, and secreted in mi...
    • p75 NTR receptor-mediated signalling, organism-specific biosystem (from REACTOME)
      p75 NTR receptor-mediated signalling, organism-specific biosystemBesides signalling through the tyrosine kinase receptors TRK A, B, and C, the mature neurotrophins NGF, BDNF, and NT3/4 signal through their common receptor p75NTR. NGF binding to p75NTR activates a ...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • FLJ41603

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    Rho guanyl-nucleotide exchange factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    regulation of Rho protein signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    rho guanine nucleotide exchange factor 37
    Names
    Rho guanine nucleotide exchange factor (GEF) 37

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001001669.3NP_001001669.2  rho guanine nucleotide exchange factor 37

      See identical proteins and their annotated locations for NP_001001669.2

      Status: VALIDATED

      Source sequence(s)
      AC021078, AC022100, AK023814, AK123597, BC041325, BF508325, BF510234
      Consensus CDS
      CCDS43385.1
      UniProtKB/Swiss-Prot
      A1IGU5
      Related
      ENSP00000328083.6, ENST00000333677.7
      Conserved Domains (4) summary
      cd07589
      Location:264452
      BAR_DNMBP; The Bin/Amphiphysin/Rvs (BAR) domain of Dynamin Binding Protein
      cd11799
      Location:510563
      SH3_ARHGEF37_C1; First C-terminal Src homology 3 domain of Rho guanine nucleotide exchange factor 37
      cd11941
      Location:606662
      SH3_ARHGEF37_C2; Second C-terminal Src homology 3 domain of Rho guanine nucleotide exchange factor 37
      pfam00621
      Location:34212
      RhoGEF; RhoGEF domain

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000005.10 Reference GRCh38.p13 Primary Assembly

      Range
      149552057..149634968
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011537642.3XP_011535944.1  rho guanine nucleotide exchange factor 37 isoform X3

      Conserved Domains (4) summary
      cd07589
      Location:275463
      BAR_DNMBP; The Bin/Amphiphysin/Rvs (BAR) domain of Dynamin Binding Protein
      cd11799
      Location:521574
      SH3_ARHGEF37_C1; First C-terminal Src homology 3 domain of Rho guanine nucleotide exchange factor 37
      cd11941
      Location:617673
      SH3_ARHGEF37_C2; Second C-terminal Src homology 3 domain of Rho guanine nucleotide exchange factor 37
      pfam00621
      Location:45223
      RhoGEF; RhoGEF domain
    2. XM_017009460.1XP_016864949.1  rho guanine nucleotide exchange factor 37 isoform X2

    3. XM_006714784.3XP_006714847.1  rho guanine nucleotide exchange factor 37 isoform X1

      See identical proteins and their annotated locations for XP_006714847.1

      UniProtKB/Swiss-Prot
      A1IGU5
      Conserved Domains (4) summary
      cd07589
      Location:264452
      BAR_DNMBP; The Bin/Amphiphysin/Rvs (BAR) domain of Dynamin Binding Protein
      cd11799
      Location:510563
      SH3_ARHGEF37_C1; First C-terminal Src homology 3 domain of Rho guanine nucleotide exchange factor 37
      cd11941
      Location:606662
      SH3_ARHGEF37_C2; Second C-terminal Src homology 3 domain of Rho guanine nucleotide exchange factor 37
      pfam00621
      Location:34212
      RhoGEF; RhoGEF domain
    4. XM_017009461.2XP_016864950.1  rho guanine nucleotide exchange factor 37 isoform X5

    5. XM_005268448.1XP_005268505.1  rho guanine nucleotide exchange factor 37 isoform X4

      Conserved Domains (3) summary
      cd07589
      Location:50238
      BAR_DNMBP; The Bin/Amphiphysin/Rvs (BAR) domain of Dynamin Binding Protein
      cd11799
      Location:296349
      SH3_ARHGEF37_C1; First C-terminal Src homology 3 domain of Rho guanine nucleotide exchange factor 37
      cd11941
      Location:392448
      SH3_ARHGEF37_C2; Second C-terminal Src homology 3 domain of Rho guanine nucleotide exchange factor 37
    6. XM_005268447.4XP_005268504.1  rho guanine nucleotide exchange factor 37 isoform X1

      See identical proteins and their annotated locations for XP_005268504.1

      UniProtKB/Swiss-Prot
      A1IGU5
      Conserved Domains (4) summary
      cd07589
      Location:264452
      BAR_DNMBP; The Bin/Amphiphysin/Rvs (BAR) domain of Dynamin Binding Protein
      cd11799
      Location:510563
      SH3_ARHGEF37_C1; First C-terminal Src homology 3 domain of Rho guanine nucleotide exchange factor 37
      cd11941
      Location:606662
      SH3_ARHGEF37_C2; Second C-terminal Src homology 3 domain of Rho guanine nucleotide exchange factor 37
      pfam00621
      Location:34212
      RhoGEF; RhoGEF domain
    Support Center