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    C5orf46 chromosome 5 open reading frame 46 [ Homo sapiens (human) ]

    Gene ID: 389336, updated on 19-Sep-2024

    Summary

    Official Symbol
    C5orf46provided by HGNC
    Official Full Name
    chromosome 5 open reading frame 46provided by HGNC
    Primary source
    HGNC:HGNC:33768
    See related
    Ensembl:ENSG00000178776 AllianceGenome:HGNC:33768
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    AP-64; SSSP1
    Summary
    Located in extracellular exosome. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in salivary gland (RPKM 5.3), skin (RPKM 3.8) and 2 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See C5orf46 in Genome Data Viewer
    Location:
    5q32
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (147885885..147906538, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (148421588..148442241, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (147272285..147286101, complement)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene formyl peptide receptor 1 pseudogene Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:147244599-147245140 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr5:147247772-147248437 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:147248438-147249104 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:147249105-147249771 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:147249772-147250438 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:147253107-147253772 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr5:147253773-147254440 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr5:147254441-147255106 Neighboring gene secretoglobin family 3A member 2 Neighboring gene eukaryotic translation elongation factor 1 gamma pseudogene 2 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:147325894-147326466 Neighboring gene uncharacterized LOC124901185 Neighboring gene serine peptidase inhibitor Kazal type 5

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General protein information

    Preferred Names
    uncharacterized protein C5orf46
    Names
    CTC-327F10.5
    skin and saliva secreted protein 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_206966.3NP_996849.2  uncharacterized protein C5orf46 precursor

      See identical proteins and their annotated locations for NP_996849.2

      Status: VALIDATED

      Source sequence(s)
      AC011352, AY358656
      Consensus CDS
      CCDS34267.1
      UniProtKB/Swiss-Prot
      A8K038, Q6UWT4, Q8WU04
      Related
      ENSP00000315370.4, ENST00000318315.5
      Conserved Domains (1) summary
      pfam15144
      Location:187
      DUF4576; Domain of unknown function (DUF4576)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

      Range
      147885885..147906538 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005268446.4XP_005268503.3  uncharacterized protein C5orf46 isoform X1

      UniProtKB/Swiss-Prot
      A8K038, Q6UWT4, Q8WU04
    2. XM_047417169.1XP_047273125.1  uncharacterized protein C5orf46 isoform X1

      UniProtKB/Swiss-Prot
      A8K038, Q6UWT4, Q8WU04

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060929.1 Alternate T2T-CHM13v2.0

      Range
      148421588..148442241 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054352568.1XP_054208543.1  uncharacterized protein C5orf46 isoform X1

      UniProtKB/Swiss-Prot
      A8K038, Q6UWT4, Q8WU04