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    NOTCH2NLA notch 2 N-terminal like A [ Homo sapiens (human) ]

    Gene ID: 388677, updated on 17-Jun-2019

    Summary

    Official Symbol
    NOTCH2NLAprovided by HGNC
    Official Full Name
    notch 2 N-terminal like Aprovided by HGNC
    Primary source
    HGNC:HGNC:31862
    See related
    Ensembl:ENSG00000264343 MIM:618023
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    N2N; NOTCH2NL
    Expression
    Ubiquitous expression in testis (RPKM 12.1), skin (RPKM 6.6) and 25 other tissues See more

    Genomic context

    See NOTCH2NLA in Genome Data Viewer
    Location:
    1q21.1
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    109.20190607 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (146151908..146229032, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (145176379..145286270)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 1719 Neighboring gene NBPF member 10 Neighboring gene uncharacterized LOC105371254 Neighboring gene RNA, U6 small nuclear 1071, pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    Knockdown of notch 2 N-terminal like (NOTCH2NL) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Potential readthrough

    Included gene: NBPF10

    Clone Names

    • FLJ35032, FLJ55807

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    Notch binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Notch binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    Notch signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    cerebral cortex development IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of Notch signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    notch homolog 2 N-terminal-like protein A
    Names
    Notch homolog 2 N-terminal like protein
    notch homolog 2 N-terminal-like protein

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001364006.1NP_001350935.1  notch homolog 2 N-terminal-like protein A isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site at a 5' exon compared to variant 1. This difference is predicted to result in the use of an upstream start codon and an isoform (2) with a longer N-terminus compared to isoform 1.
      Source sequence(s)
      AC239799
      Conserved Domains (1) summary
      cd00054
      Location:156192
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    2. NM_203458.4NP_982283.2  notch homolog 2 N-terminal-like protein A isoform 1

      See identical proteins and their annotated locations for NP_982283.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes isoform 1
      Source sequence(s)
      AC239799, BC010154, BM792637
      Consensus CDS
      CCDS72880.1
      UniProtKB/Swiss-Prot
      Q7Z3S9
      Related
      ENSP00000354929.6, ENST00000362074.7
      Conserved Domains (1) summary
      cd00054
      Location:143179
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

      Range
      146151908..146229032 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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