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    KRT34 keratin 34 [ Homo sapiens (human) ]

    Gene ID: 3885, updated on 17-Jun-2019

    Summary

    Official Symbol
    KRT34provided by HGNC
    Official Full Name
    keratin 34provided by HGNC
    Primary source
    HGNC:HGNC:6452
    See related
    Ensembl:ENSG00000131737 MIM:602763
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HA4; Ha-4; hHa4; KRTHA4
    Summary
    The protein encoded by this gene is a member of the keratin gene family. As a type I hair keratin, it is an acidic protein which heterodimerizes with type II keratins to form hair and nails. The type I hair keratins are clustered in a region of chromosome 17q12-q21 and have the same direction of transcription. [provided by RefSeq, Jul 2008]
    Expression
    Low expression observed in reference dataset See more
    Orthologs

    Genomic context

    See KRT34 in Genome Data Viewer
    Location:
    17q21.2
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    109.20190607 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (41377665..41383816, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (39533921..39538636, complement)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105371778 Neighboring gene keratin 33B Neighboring gene keratin 31 Neighboring gene uncharacterized LOC100505782 Neighboring gene keratin 41 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    • Developmental Biology, organism-specific biosystem (from REACTOME)
      Developmental Biology, organism-specific biosystemAs a first step towards capturing the array of processes by which a fertilized egg gives rise to the diverse tissues of the body, examples of three kinds of processes have been annotated. These are a...
    • Keratinization, organism-specific biosystem (from REACTOME)
      Keratinization, organism-specific biosystemKeratins are the major structural protein of vertebrate epidermis, constituting up to 85% of a fully differentiated keratinocyte (Fuchs 1995). Keratins belong to a superfamily of intermediate filamen...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    structural molecule activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    cornification TAS
    Traceable Author Statement
    more info
     
    epidermis development TAS
    Traceable Author Statement
    more info
    PubMed 
    keratinization TAS
    Traceable Author Statement
    more info
     
    Component Evidence Code Pubs
    cytosol TAS
    Traceable Author Statement
    more info
     
    extracellular space HDA PubMed 
    intermediate filament IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    keratin, type I cuticular Ha4
    Names
    K34
    hair keratin, type I Ha4
    hard keratin, type I, 4
    keratin 34, type I
    keratin, hair, acidic, 4

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_012291.1 RefSeqGene

      Range
      5001..9716
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_021013.3NP_066293.2  keratin, type I cuticular Ha4

      See identical proteins and their annotated locations for NP_066293.2

      Status: REVIEWED

      Source sequence(s)
      Y16790
      Consensus CDS
      CCDS11390.1
      UniProtKB/Swiss-Prot
      O76011
      Related
      ENSP00000377570.2, ENST00000394001.1
      Conserved Domains (1) summary
      pfam00038
      Location:97408
      Filament; Intermediate filament protein

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

      Range
      41377665..41383816 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011524793.2XP_011523095.1  keratin, type I cuticular Ha4 isoform X1

      Conserved Domains (1) summary
      pfam00038
      Location:73384
      Filament; Intermediate filament protein

    Reference GRCh38.p13 ALT_REF_LOCI_1

    Genomic

    1. NW_003315953.2 Reference GRCh38.p13 ALT_REF_LOCI_1

      Range
      57880..62596
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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