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    KRT33B keratin 33B [ Homo sapiens (human) ]

    Gene ID: 3884, updated on 17-Jun-2024

    Summary

    Official Symbol
    KRT33Bprovided by HGNC
    Official Full Name
    keratin 33Bprovided by HGNC
    Primary source
    HGNC:HGNC:6451
    See related
    Ensembl:ENSG00000131738 MIM:602762; AllianceGenome:HGNC:6451
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    K33B; HA3II; Ha-3II; KRTHA3A; KRTHA3B; hHa3-II
    Summary
    This gene encodes a member of the keratin gene family. This gene is one of multiple type I hair keratin genes that are clustered in a region of chromosome 17q12-q21 and have the same direction of transcription. As a type I hair keratin, the encoded protein is an acidic protein which heterodimerizes with type II keratins to form hair and nails. There are two isoforms of this protein, encoded by two separate genes, keratin 33A and keratin 33B. [provided by RefSeq, May 2012]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    NEW
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    Genomic context

    See KRT33B in Genome Data Viewer
    Location:
    17q21.2
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (41363498..41369813, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (42219031..42225346, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (39519750..39526065, complement)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:39502712-39503212 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:39503213-39503713 Neighboring gene keratin 33A Neighboring gene uncharacterized LOC105371778 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:39520859-39521360 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr17:39537551-39538750 Neighboring gene keratin 34 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:39549785-39550286 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:39550287-39550786 Neighboring gene keratin 31

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables structural molecule activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in epithelial cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in hair cycle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in intermediate filament organization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in extracellular exosome HDA PubMed 
    located_in extracellular space HDA PubMed 
    located_in intermediate filament IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    keratin, type I cuticular Ha3-II
    Names
    hair keratin, type I Ha3-II
    hard keratin, type I, 3II
    keratin 33B, type I
    keratin, hair, acidic, 3B
    type I hair keratin 3B

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_012290.1 RefSeqGene

      Range
      4983..11298
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_002279.5NP_002270.1  keratin, type I cuticular Ha3-II

      See identical proteins and their annotated locations for NP_002270.1

      Status: REVIEWED

      Source sequence(s)
      AC003958, BC009971
      Consensus CDS
      CCDS11389.1
      UniProtKB/Swiss-Prot
      O76010, Q14525
      Related
      ENSP00000251646.3, ENST00000251646.8
      Conserved Domains (1) summary
      pfam00038
      Location:55366
      Filament; Intermediate filament protein

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      41363498..41369813 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p14 PATCHES

    Genomic

    1. NW_025791801.1 Reference GRCh38.p14 PATCHES

      Range
      303402..309717 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p14 ALT_REF_LOCI_1

    Genomic

    1. NW_003315953.2 Reference GRCh38.p14 ALT_REF_LOCI_1

      Range
      70448..76763
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      42219031..42225346 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)