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    INCA1 inhibitor of CDK, cyclin A1 interacting protein 1 [ Homo sapiens (human) ]

    Gene ID: 388324, updated on 26-Oct-2022

    Summary

    Official Symbol
    INCA1provided by HGNC
    Official Full Name
    inhibitor of CDK, cyclin A1 interacting protein 1provided by HGNC
    Primary source
    HGNC:HGNC:32224
    See related
    Ensembl:ENSG00000196388 MIM:617374; AllianceGenome:HGNC:32224
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HSD45
    Summary
    Enables cyclin binding activity; cyclin-dependent protein serine/threonine kinase inhibitor activity; and identical protein binding activity. Acts upstream of or within negative regulation of cyclin-dependent protein serine/threonine kinase activity. Located in cytoplasm and nuclear body. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in testis (RPKM 10.5), prostate (RPKM 1.7) and 21 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See INCA1 in Genome Data Viewer
    Location:
    17p13.2
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    110 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (4988130..4997522, complement)
    110 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (4878461..4887846, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (4891425..4900817, complement)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124903901 Neighboring gene calmodulin binding transcription activator 2 Neighboring gene microRNA 6865 Neighboring gene CAMTA2 antisense RNA 1 Neighboring gene kinesin family member 1C Neighboring gene KIF1C antisense RNA 1 Neighboring gene uncharacterized LOC105371501 Neighboring gene solute carrier family 52 member 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
    EBI GWAS Catalog

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC148150, MGC148151

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables cyclin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables cyclin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables cyclin binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables cyclin-dependent protein serine/threonine kinase inhibitor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables cyclin-dependent protein serine/threonine kinase inhibitor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein-containing complex binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nuclear body IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001167985.2NP_001161457.1  protein INCA1 isoform 2

      See identical proteins and their annotated locations for NP_001161457.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and uses an alternate in-frame splice site in the coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1. Both variants 3 and 4 encode the same isoform (2).
      Source sequence(s)
      AY601907, AY604176
      Consensus CDS
      CCDS11064.1
      UniProtKB/Swiss-Prot
      Q0VD86
      Related
      ENSP00000461844.1, ENST00000575780.5
      Conserved Domains (1) summary
      pfam15142
      Location:12175
      INCA1
    2. NM_001167986.2NP_001161458.1  protein INCA1 isoform 1

      See identical proteins and their annotated locations for NP_001161458.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1). Both variants 1 and 2 encode the same isoform (1).
      Source sequence(s)
      AY601906, AY604176, BC119781
      Consensus CDS
      CCDS54074.1
      UniProtKB/Swiss-Prot
      Q0VD86, Q6PKN9
      Related
      ENSP00000458316.1, ENST00000574617.1
      Conserved Domains (1) summary
      pfam15142
      Location:12190
      INCA1
    3. NM_001167987.2NP_001161459.1  protein INCA1 isoform 1

      See identical proteins and their annotated locations for NP_001161459.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same isoform (1).
      Source sequence(s)
      AY601906, AY604176, BC122873
      Consensus CDS
      CCDS54074.1
      UniProtKB/Swiss-Prot
      Q0VD86, Q6PKN9
      Related
      ENSP00000460673.1, ENST00000576820.5
      Conserved Domains (1) summary
      pfam15142
      Location:12190
      INCA1
    4. NM_001394788.1NP_001381717.1  protein INCA1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC004771
      Consensus CDS
      CCDS54074.1
      UniProtKB/Swiss-Prot
      Q6PKN9
      Conserved Domains (1) summary
      pfam15142
      Location:12190
      INCA1
    5. NM_001394789.1NP_001381718.1  protein INCA1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC004771
      Consensus CDS
      CCDS54074.1
      UniProtKB/Swiss-Prot
      Q6PKN9
      Related
      ENSP00000511805.1, ENST00000695324.1
      Conserved Domains (1) summary
      pfam15142
      Location:12190
      INCA1
    6. NM_001394790.1NP_001381719.1  protein INCA1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC004771
      Consensus CDS
      CCDS11064.1
      Conserved Domains (1) summary
      pfam15142
      Location:12175
      INCA1
    7. NM_001394791.1NP_001381720.1  protein INCA1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC004771
      Consensus CDS
      CCDS11064.1
      Conserved Domains (1) summary
      pfam15142
      Location:12175
      INCA1
    8. NM_213726.3NP_998891.2  protein INCA1 isoform 2

      See identical proteins and their annotated locations for NP_998891.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and uses an alternate in-frame splice site in the coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1. Both variants 3 and 4 encode the same isoform (2).
      Source sequence(s)
      AY601906, AY604176
      Consensus CDS
      CCDS11064.1
      UniProtKB/Swiss-Prot
      Q0VD86
      Related
      ENSP00000347129.3, ENST00000355025.7
      Conserved Domains (1) summary
      pfam15142
      Location:12175
      INCA1

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      4988130..4997522 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011523834.3XP_011522136.1  protein INCA1 isoform X2

      Conserved Domains (1) summary
      pfam15142
      Location:12137
      INCA1; INCA1
    2. XM_005256628.6XP_005256685.1  protein INCA1 isoform X1

      See identical proteins and their annotated locations for XP_005256685.1

      UniProtKB/Swiss-Prot
      Q0VD86, Q6PKN9
      Conserved Domains (1) summary
      pfam15142
      Location:12190
      INCA1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      4878461..4887846 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)