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    NPSR1 neuropeptide S receptor 1 [ Homo sapiens (human) ]

    Gene ID: 387129, updated on 18-Sep-2024

    Summary

    Official Symbol
    NPSR1provided by HGNC
    Official Full Name
    neuropeptide S receptor 1provided by HGNC
    Primary source
    HGNC:HGNC:23631
    See related
    Ensembl:ENSG00000187258 MIM:608595; AllianceGenome:HGNC:23631
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    GPRA; NPSR; VRR1; ASRT2; PGR14; GPR154
    Summary
    This gene encodes a member of the vasopressin/oxytocin subfamily of G protein-coupled receptors. The encoded membrane protein acts as a receptor for neuropeptide S and affects a variety of cellular processes through its signaling. Increased expression of this gene in ciliated cells of the respiratory epithelium and in bronchial smooth muscle cells is associated with asthma. Polymorphisms in this gene have also been associated with asthma susceptibility, panic disorders, inflammatory bowel disease, and rheumatoid arthritis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    NEW
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    Genomic context

    See NPSR1 in Genome Data Viewer
    Location:
    7p14.3
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (34658218..34878332)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (34798021..35019005)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (34697830..34917944)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene ReSE screen-validated silencer GRCh37_chr7:33972520-33972786 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:34033417-34034047 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:34034048-34034677 Neighboring gene BMP binding endothelial regulator Neighboring gene MED14-independent group 3 enhancer GRCh37_chr7:34074011-34075210 Neighboring gene VISTA enhancer hs1336 Neighboring gene NANOG hESC enhancer GRCh37_chr7:34115590-34116091 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:34214913-34215520 Neighboring gene NANOG hESC enhancer GRCh37_chr7:34251459-34251988 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr7:34258701-34259255 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr7:34264670-34265500 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25837 Neighboring gene RNA, U6 small nuclear 438, pseudogene Neighboring gene NPSR1 antisense RNA 1 Neighboring gene ReSE screen-validated silencer GRCh37_chr7:34476732-34476921 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:34553347-34553924 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:34592037-34592538 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr7:34691494-34692079 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr7:34694009-34695208 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:34699869-34700706 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:34701543-34702378 Neighboring gene ribosomal protein L7 pseudogene 31 Neighboring gene RNA, 7SL, cytoplasmic 132, pseudogene Neighboring gene non-SMC condensin I complex subunit D2 pseudogene 1 Neighboring gene uncharacterized LOC102724723 Neighboring gene dpy-19 like C-mannosyltransferase 1 Neighboring gene microRNA 548n

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    Asthma-related traits, susceptibility to, 2
    MedGen: C1837811 OMIM: 608584 GeneReviews: Not available
    Compare labs

    EBI GWAS Catalog

    Description
    Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.
    EBI GWAS Catalog

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables neuropeptide receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables neuropeptide receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables vasopressin receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    neuropeptide S receptor
    Names
    G-protein coupled receptor 154
    G-protein coupled receptor PGR14
    G-protein coupled receptor for asthma susceptibility
    vasopressin receptor-related receptor 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_012185.2 RefSeqGene

      Range
      4934..196694
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001300933.2NP_001287862.1  neuropeptide S receptor isoform B short

      See identical proteins and their annotated locations for NP_001287862.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) uses an alternate in-frame splice site in the central coding region, and uses an alternate 3-terminal exon, compared to variant 1. The encoded isoform (B short, 15947423) is shorter and has a distinct C-terminus, compared to isoform A.
      Source sequence(s)
      AC005493, AK172847, AY310328
      Consensus CDS
      CCDS75580.1
      UniProtKB/TrEMBL
      A0A090N8G9
      Related
      ENSP00000433258.1, ENST00000531252.5
      Conserved Domains (1) summary
      pfam00001
      Location:66319
      7tm_1; 7 transmembrane receptor (rhodopsin family)
    2. NM_001300934.2NP_001287863.1  neuropeptide S receptor isoform F

      See identical proteins and their annotated locations for NP_001287863.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) lacks two consecutive in-frame exons in the central coding region, compared to variant 1. The encoded isoform (F, PMID: 15947423) is shorter, compared to isoform A.
      Source sequence(s)
      AC005493, AK172847, AY310332
      Consensus CDS
      CCDS75581.1
      UniProtKB/TrEMBL
      B7ZMA2
      Related
      ENSP00000370953.1, ENST00000381542.5
      Conserved Domains (1) summary
      pfam00001
      Location:95264
      7tm_1; 7 transmembrane receptor (rhodopsin family)
    3. NM_001300935.2NP_001287864.1  neuropeptide S receptor isoform G

      See identical proteins and their annotated locations for NP_001287864.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) includes an alternate exon in the 3' coding region, which results in a frameshift, compared to variant 1. The encoded isoform (G) has a longer and distinct C-terminus, compared to isoform A.
      Source sequence(s)
      AC005493, AK172847, AY310326, AY956448
      Consensus CDS
      CCDS75579.1
      UniProtKB/TrEMBL
      A0A090N8G9
      Related
      ENSP00000370950.3, ENST00000381539.3
      Conserved Domains (1) summary
      pfam00001
      Location:66330
      7tm_1; 7 transmembrane receptor (rhodopsin family)
    4. NM_207172.2NP_997055.1  neuropeptide S receptor isoform A

      See identical proteins and their annotated locations for NP_997055.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes isoform A (PMID: 15947423).
      Source sequence(s)
      AC005493, AY310326
      Consensus CDS
      CCDS5444.1
      UniProtKB/Swiss-Prot
      A2RTZ4, Q2XP58, Q56H76, Q56H77, Q56H78, Q6JSL4, Q6JSL5, Q6JSL6, Q6JSL7, Q6JSL8, Q6W5P3, Q6W5P4, Q6ZMB8
      UniProtKB/TrEMBL
      A0A090N8G9, A0A090N8Z1
      Related
      ENSP00000353788.1, ENST00000360581.6
      Conserved Domains (1) summary
      pfam00001
      Location:66330
      7tm_1; 7 transmembrane receptor (rhodopsin family)
    5. NM_207173.2NP_997056.1  neuropeptide S receptor isoform B

      See identical proteins and their annotated locations for NP_997056.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate 3' terminal exon, compared to variant 1. The encoded isoform (B, PMID: 15947423) has a longer and distinct C-terminus, compared to isoform A.
      Source sequence(s)
      AC005493, AY310327
      Consensus CDS
      CCDS5443.1
      UniProtKB/TrEMBL
      A0A090N8G9
      Related
      ENSP00000352839.1, ENST00000359791.5
      Conserved Domains (1) summary
      cd15197
      Location:50341
      7tmA_NPSR; neuropeptide S receptor, member of the class A family of seven-transmembrane G protein-coupled receptors

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

      Range
      34658218..34878332
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060931.1 Alternate T2T-CHM13v2.0

      Range
      34798021..35019005
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)