U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    KRT15 keratin 15 [ Homo sapiens (human) ]

    Gene ID: 3866, updated on 7-Apr-2024

    Summary

    Official Symbol
    KRT15provided by HGNC
    Official Full Name
    keratin 15provided by HGNC
    Primary source
    HGNC:HGNC:6421
    See related
    Ensembl:ENSG00000171346 MIM:148030; AllianceGenome:HGNC:6421
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    K15; CK15; K1CO
    Summary
    The protein encoded by this gene is a member of the keratin gene family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. Most of the type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains and are clustered in a region on chromosome 17q21.2. [provided by RefSeq, Jul 2008]
    Expression
    Biased expression in skin (RPKM 317.3), esophagus (RPKM 283.6) and 1 other tissue See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Location:
    17q21.2
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (41513745..41518890, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (42369289..42379059, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (39669997..39675142, complement)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:39642150-39643103 Neighboring gene keratin 36 Neighboring gene keratin 13 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:39672893-39673777 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:39675482-39676481 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr17:39677595-39678794 Neighboring gene microRNA 6510 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:39683757-39684456 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:39684457-39685154 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:39685155-39685852 Neighboring gene CRISPRi-validated cis-regulatory element chr17.2493 Neighboring gene keratin 19 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:39695425-39696045 Neighboring gene CRISPRi-validated cis-regulatory element chr17.2497 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:39705412-39706025 Neighboring gene long intergenic non-protein coding RNA 974 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:39708567-39709067

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables scaffold protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables structural constituent of cytoskeleton TAS
    Traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in epidermis development TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in epithelial cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in intermediate filament organization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in extracellular exosome HDA PubMed 
    located_in intermediate filament IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleus HDA PubMed 

    General protein information

    Preferred Names
    keratin, type I cytoskeletal 15
    Names
    CK-15
    cytokeratin 15
    keratin 15, type I
    keratin-15, basic
    keratin-15, beta
    type I cytoskeletal 15

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_012284.2 RefSeqGene

      Range
      5000..10145
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_002275.4NP_002266.3  keratin, type I cytoskeletal 15

      Status: REVIEWED

      Source sequence(s)
      AC019349
      Consensus CDS
      CCDS11398.1
      UniProtKB/Swiss-Prot
      B3KQY1, B3KRA2, E0CX14, P19012, Q53XV8, Q9BUG4
      UniProtKB/TrEMBL
      B3KVF5
      Related
      ENSP00000254043.3, ENST00000254043.8
      Conserved Domains (1) summary
      pfam00038
      Location:104416
      Filament; Intermediate filament protein

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      41513745..41518890 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011524784.4XP_011523086.1  keratin, type I cytoskeletal 15 isoform X1

      UniProtKB/TrEMBL
      B3KVF5
      Conserved Domains (1) summary
      pfam00038
      Location:104423
      Filament; Intermediate filament protein
    2. XM_017024614.3XP_016880103.1  keratin, type I cytoskeletal 15 isoform X2

      UniProtKB/TrEMBL
      B3KVF5
      Conserved Domains (1) summary
      pfam00038
      Location:104423
      Filament; Intermediate filament protein

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      42369289..42379059 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054316023.1XP_054171998.1  keratin, type I cytoskeletal 15 isoform X3

    2. XM_054316022.1XP_054171997.1  keratin, type I cytoskeletal 15 isoform X1

    3. XM_054316024.1XP_054171999.1  keratin, type I cytoskeletal 15 isoform X2