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    IPO5 importin 5 [ Homo sapiens (human) ]

    Gene ID: 3843, updated on 28-Oct-2024

    Summary

    Official Symbol
    IPO5provided by HGNC
    Official Full Name
    importin 5provided by HGNC
    Primary source
    HGNC:HGNC:6402
    See related
    Ensembl:ENSG00000065150 MIM:602008; AllianceGenome:HGNC:6402
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    IMB3; Pse1; imp5; KPNB3; RANBP5
    Summary
    Nucleocytoplasmic transport, a signal- and energy-dependent process, takes place through nuclear pore complexes embedded in the nuclear envelope. The import of proteins containing a nuclear localization signal (NLS) requires the NLS import receptor, a heterodimer of importin alpha and beta subunits also known as karyopherins. Importin alpha binds the NLS-containing cargo in the cytoplasm and importin beta docks the complex at the cytoplasmic side of the nuclear pore complex. In the presence of nucleoside triphosphates and the small GTP binding protein Ran, the complex moves into the nuclear pore complex and the importin subunits dissociate. Importin alpha enters the nucleoplasm with its passenger protein and importin beta remains at the pore. Interactions between importin beta and the FG repeats of nucleoporins are essential in translocation through the pore complex. The protein encoded by this gene is a member of the importin beta family. [provided by RefSeq, Jul 2008]
    Expression
    Broad expression in testis (RPKM 84.9), ovary (RPKM 29.9) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See IPO5 in Genome Data Viewer
    Location:
    13q32.2
    Exon count:
    32
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 13 NC_000013.11 (97953675..98024296)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 13 NC_060937.1 (97160508..97231138)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (98605929..98676550)

    Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA U13 Neighboring gene ReSE screen-validated silencer GRCh37_chr13:98564348-98564553 Neighboring gene ReSE screen-validated silencer GRCh37_chr13:98565660-98565942 Neighboring gene ribosomal protein L7a pseudogene 61 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5453 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5454 Neighboring gene ferritin light chain pseudogene 8 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:98713754-98714350 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:98716143-98716738 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:98716739-98717336 Neighboring gene uncharacterized LOC105370328 Neighboring gene uncharacterized LOC107984566 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5455 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5456 Neighboring gene Sharpr-MPRA regulatory region 2492 Neighboring gene FERM, ARH/RhoGEF and pleckstrin domain protein 1 Neighboring gene ring finger protein 113B

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Genome-wide association study of primary dentition pit-and-fissure and smooth surface caries.
    EBI GWAS Catalog

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    HIV-1 infection (VSV-G pseudotyped) of CEMT4 T cells downregulates plasma membrane expression of IPO5 PubMed

    Protein interactions

    Protein Gene Interaction Pubs
    Rev rev importin beta specifically binds to the Rev nuclear localization signal (NLS, amino acids 35-50) and mediates the nuclear import of Rev PubMed
    rev importin beta can inhibit the interaction of HIV-1 Rev with HIV-1 RRE RNA PubMed
    Tat tat The binding of HIV-1 Tat with importin beta is inhibited by RanGTP PubMed
    tat Importin beta binds to the HIV-1 Tat protein nuclear localization signal (NLS; amino acids 49-57) and mediates the nuclear import of Tat through a novel import pathway PubMed
    Vpr vpr HIV-1 Vpr causes increased levels of CyclinB1, Plk1, and Cdk1 in a complex with the nuclear transport and spindle assembly protein, importin beta PubMed
    vpr HIV-1 Vpr co-localizes with karyopherin beta and regulates karyopherin beta-mediated docking of the HIV-1 preintegration complex at the nuclear envelope, however multiple reports indicate the two proteins do not directly interact PubMed
    capsid gag The interaction of HIV-1 CA with human cellular importin 5 protein (IPO5) is identified by yeast two-hybrid screen PubMed
    integrase gag-pol Some reports indicate a possible role for the interactions between karyopherin alpha and beta with HIV-1 integrase in the nuclear import of HIV-1 preintegration complexes (PIC), while other reports indicate integrase is not involved in PIC nuclear import PubMed
    gag-pol Karyopherin beta binds to complexes between HIV-1 integrase (integrase/GST fusion protein) and karyopherin alpha, but not to integrase alone PubMed
    gag-pol Karyopherin alpha and beta are reported to interact with HIV-1 integrase (IN) to facilitate nuclear import of IN, however a conflicting report indicates nuclear accumulation of IN does not involve karyopherin alpha, beta 1, or beta 2 mediated pathways PubMed
    matrix gag Karyopherin beta mediates the nuclear import of HIV-1 preintegration complexes through karyopherin alpha, which binds directly to nuclear localization signals in HIV-1 Matrix PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC2068, FLJ43041, DKFZp686O1576

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables GTPase inhibitor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables RNA binding HDA PubMed 
    enables nuclear import signal receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables nuclear import signal receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables nuclear import signal receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables nuclear localization sequence binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables small GTPase binding IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    located_in membrane HDA PubMed 
    is_active_in nuclear membrane IC
    Inferred by Curator
    more info
    PubMed 
    located_in nuclear membrane IDA
    Inferred from Direct Assay
    more info
     
    part_of nuclear pore TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    importin-5
    Names
    Kap beta3 import receptor
    PSE1 homolog
    RAN binding protein 5
    Ran_GTP binding protein 5
    importin beta-3 subunit
    importin subunit beta-3
    karyopherin (importin) beta 3
    karyopherin beta-3
    ran-binding protein 5

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_002271.6NP_002262.4  importin-5

      Status: REVIEWED

      Source sequence(s)
      AF339834, AK125031, AL137120, AL705630, BC000947, BC001497, BC045640, BU618294, Y08890
      Consensus CDS
      CCDS31999.2
      UniProtKB/Swiss-Prot
      B4DZA0, O00410, O15257, Q5T578, Q86XC7
      UniProtKB/TrEMBL
      H0Y8C6
      Related
      ENSP00000499125.1, ENST00000651721.2
      Conserved Domains (6) summary
      COG5215
      Location:13634
      KAP95; Karyopherin (importin) beta [Intracellular trafficking and secretion]
      sd00044
      Location:355387
      HEAT; HEAT repeat [structural motif]
      pfam13513
      Location:921966
      HEAT_EZ; HEAT-like repeat
      pfam18808
      Location:268357
      Importin_rep_4; Importin repeat
      pfam18816
      Location:10051051
      Importin_rep_5; Importin repeat
      pfam18829
      Location:765874
      Importin_rep_6; Importin repeat 6

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000013.11 Reference GRCh38.p14 Primary Assembly

      Range
      97953675..98024296
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024449346.2XP_024305114.1  importin-5 isoform X1

      UniProtKB/TrEMBL
      H0Y8C6
      Conserved Domains (6) summary
      COG5215
      Location:31652
      KAP95; Karyopherin (importin) beta [Intracellular trafficking and secretion]
      sd00044
      Location:373405
      HEAT; HEAT repeat [structural motif]
      pfam13513
      Location:939984
      HEAT_EZ; HEAT-like repeat
      pfam18808
      Location:286375
      Importin_rep_4; Importin repeat
      pfam18816
      Location:10231069
      Importin_rep_5; Importin repeat
      pfam18829
      Location:783892
      Importin_rep_6; Importin repeat 6
    2. XM_011521089.3XP_011519391.1  importin-5 isoform X1

      See identical proteins and their annotated locations for XP_011519391.1

      UniProtKB/TrEMBL
      H0Y8C6
      Conserved Domains (6) summary
      COG5215
      Location:31652
      KAP95; Karyopherin (importin) beta [Intracellular trafficking and secretion]
      sd00044
      Location:373405
      HEAT; HEAT repeat [structural motif]
      pfam13513
      Location:939984
      HEAT_EZ; HEAT-like repeat
      pfam18808
      Location:286375
      Importin_rep_4; Importin repeat
      pfam18816
      Location:10231069
      Importin_rep_5; Importin repeat
      pfam18829
      Location:783892
      Importin_rep_6; Importin repeat 6
    3. XM_047430298.1XP_047286254.1  importin-5 isoform X1

    4. XM_047430299.1XP_047286255.1  importin-5 isoform X2

      UniProtKB/Swiss-Prot
      B4DZA0, O00410, O15257, Q5T578, Q86XC7
      Related
      ENSP00000350219.3, ENST00000357602.7
    5. XM_011521087.3XP_011519389.1  importin-5 isoform X1

      See identical proteins and their annotated locations for XP_011519389.1

      UniProtKB/TrEMBL
      H0Y8C6
      Conserved Domains (6) summary
      COG5215
      Location:31652
      KAP95; Karyopherin (importin) beta [Intracellular trafficking and secretion]
      sd00044
      Location:373405
      HEAT; HEAT repeat [structural motif]
      pfam13513
      Location:939984
      HEAT_EZ; HEAT-like repeat
      pfam18808
      Location:286375
      Importin_rep_4; Importin repeat
      pfam18816
      Location:10231069
      Importin_rep_5; Importin repeat
      pfam18829
      Location:783892
      Importin_rep_6; Importin repeat 6
    6. XM_047430297.1XP_047286253.1  importin-5 isoform X1

    7. XM_011521088.3XP_011519390.1  importin-5 isoform X1

      See identical proteins and their annotated locations for XP_011519390.1

      UniProtKB/TrEMBL
      H0Y8C6
      Conserved Domains (6) summary
      COG5215
      Location:31652
      KAP95; Karyopherin (importin) beta [Intracellular trafficking and secretion]
      sd00044
      Location:373405
      HEAT; HEAT repeat [structural motif]
      pfam13513
      Location:939984
      HEAT_EZ; HEAT-like repeat
      pfam18808
      Location:286375
      Importin_rep_4; Importin repeat
      pfam18816
      Location:10231069
      Importin_rep_5; Importin repeat
      pfam18829
      Location:783892
      Importin_rep_6; Importin repeat 6
    8. XM_047430296.1XP_047286252.1  importin-5 isoform X1

    9. XM_017020562.2XP_016876051.1  importin-5 isoform X1

      UniProtKB/TrEMBL
      H0Y8C6
      Related
      ENSP00000261574.5, ENST00000261574.10
      Conserved Domains (6) summary
      COG5215
      Location:31652
      KAP95; Karyopherin (importin) beta [Intracellular trafficking and secretion]
      sd00044
      Location:373405
      HEAT; HEAT repeat [structural motif]
      pfam13513
      Location:939984
      HEAT_EZ; HEAT-like repeat
      pfam18808
      Location:286375
      Importin_rep_4; Importin repeat
      pfam18816
      Location:10231069
      Importin_rep_5; Importin repeat
      pfam18829
      Location:783892
      Importin_rep_6; Importin repeat 6
    10. XM_005254052.4XP_005254109.1  importin-5 isoform X1

      See identical proteins and their annotated locations for XP_005254109.1

      UniProtKB/TrEMBL
      H0Y8C6
      Conserved Domains (6) summary
      COG5215
      Location:31652
      KAP95; Karyopherin (importin) beta [Intracellular trafficking and secretion]
      sd00044
      Location:373405
      HEAT; HEAT repeat [structural motif]
      pfam13513
      Location:939984
      HEAT_EZ; HEAT-like repeat
      pfam18808
      Location:286375
      Importin_rep_4; Importin repeat
      pfam18816
      Location:10231069
      Importin_rep_5; Importin repeat
      pfam18829
      Location:783892
      Importin_rep_6; Importin repeat 6
    11. XM_047430300.1XP_047286256.1  importin-5 isoform X2

      UniProtKB/Swiss-Prot
      B4DZA0, O00410, O15257, Q5T578, Q86XC7
      Related
      ENSP00000418393.1, ENST00000490680.5

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060937.1 Alternate T2T-CHM13v2.0

      Range
      97160508..97231138
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054374507.1XP_054230482.1  importin-5 isoform X1

    2. XM_054374511.1XP_054230486.1  importin-5 isoform X1

    3. XM_054374514.1XP_054230489.1  importin-5 isoform X1

    4. XM_054374515.1XP_054230490.1  importin-5 isoform X2

      UniProtKB/Swiss-Prot
      B4DZA0, O00410, O15257, Q5T578, Q86XC7
    5. XM_054374508.1XP_054230483.1  importin-5 isoform X1

    6. XM_054374513.1XP_054230488.1  importin-5 isoform X1

    7. XM_054374509.1XP_054230484.1  importin-5 isoform X1

    8. XM_054374512.1XP_054230487.1  importin-5 isoform X1

    9. XM_054374510.1XP_054230485.1  importin-5 isoform X1

    10. XM_054374506.1XP_054230481.1  importin-5 isoform X1