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    ARF1 ADP ribosylation factor 1 [ Homo sapiens (human) ]

    Gene ID: 375, updated on 6-Sep-2021

    Summary

    Official Symbol
    ARF1provided by HGNC
    Official Full Name
    ADP ribosylation factor 1provided by HGNC
    Primary source
    HGNC:HGNC:652
    See related
    Ensembl:ENSG00000143761 MIM:103180
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PVNH8
    Summary
    ADP-ribosylation factor 1 (ARF1) is a member of the human ARF gene family. The family members encode small guanine nucleotide-binding proteins that stimulate the ADP-ribosyltransferase activity of cholera toxin and play a role in vesicular trafficking as activators of phospholipase D. The gene products, including 6 ARF proteins and 11 ARF-like proteins, constitute a family of the RAS superfamily. The ARF proteins are categorized as class I (ARF1, ARF2 and ARF3), class II (ARF4 and ARF5) and class III (ARF6), and members of each class share a common gene organization. The ARF1 protein is localized to the Golgi apparatus and has a central role in intra-Golgi transport. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in placenta (RPKM 152.3), thyroid (RPKM 137.5) and 25 other tissues See more
    Orthologs
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    Genomic context

    See ARF1 in Genome Data Viewer
    Location:
    1q42.13
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    109.20210514 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (228082708..228099212)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (228270409..228286913)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene Wnt family member 3A Neighboring gene long intergenic non-protein coding RNA 2809 Neighboring gene microRNA 3620 Neighboring gene chromosome 1 open reading frame 35 Neighboring gene mitochondrial ribosomal protein L55

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    Knockdown of ADP-ribosylation factor 1 (ARF1) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

    Protein interactions

    Protein Gene Interaction Pubs
    Nef nef Functional ARF1 is required for HIV-1 Nef-dependent endogenous HLA-A2 and CD4 downregulation in HIV-infected primary T cells PubMed
    nef Dominant active ARF1 (Q71L) potently stabilizes interactions among AP-1 mu1, HIV-1 Nef, and HLA-A2 and that the formation of a static complex sequesters necessary trafficking components PubMed
    nef Nef binds GTPase ARF1 directly via residues E154 and E155 and recruits the GTPase to endosomal membranes PubMed
    Pr55(Gag) gag GGA-mediated inhibition of virus particle release results from ARF1 sequestration, suggesting the interaction between HIV-1 Gag and ARF1 PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables GDP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables GTP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables GTPase activity TAS
    Traceable Author Statement
    more info
     
    enables RNA binding HDA PubMed 
    enables magnesium ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables phospholipase D activator activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein domain specific binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in Golgi to transport vesicle transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in actin filament organization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular copper ion homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cellular response to virus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in dendritic spine organization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in intracellular protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in long-term synaptic depression ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in lysosomal membrane organization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in mitotic cleavage furrow ingression IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of ER to Golgi vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of calcium ion-dependent exocytosis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of dendritic spine development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of endocytosis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of late endosome to lysosome transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of protein secretion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of sodium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in postsynaptic actin cytoskeleton organization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of Arp2/3 complex-mediated actin nucleation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of catalytic activity IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of phospholipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of receptor internalization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in synaptic vesicle budding IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in very-low-density lipoprotein particle assembly IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in COPI-coated vesicle IEA
    Inferred from Electronic Annotation
    more info
     
    located_in Golgi membrane TAS
    Traceable Author Statement
    more info
     
    located_in cell leading edge IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in extracellular exosome HDA PubMed 
    located_in focal adhesion HDA PubMed 
    located_in glutamatergic synapse IEA
    Inferred from Electronic Annotation
    more info
     
    located_in late endosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in neuron projection IEA
    Inferred from Electronic Annotation
    more info
     
    located_in perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in peroxisomal membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in postsynaptic density IEA
    Inferred from Electronic Annotation
    more info
     
    part_of protein-containing complex IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in sarcomere IEA
    Inferred from Electronic Annotation
    more info
     
    located_in trans-Golgi network IEA
    Inferred from Electronic Annotation
    more info
     

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001024226.2NP_001019397.1  ADP-ribosylation factor 1

      See identical proteins and their annotated locations for NP_001019397.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) has an alternate and shorter 5' UTR, as compared to variant 1.
      Source sequence(s)
      AK000620, BF337061, BM844480
      Consensus CDS
      CCDS1565.1
      UniProtKB/Swiss-Prot
      P84077
      UniProtKB/TrEMBL
      A0A024R3Q3
      Related
      ENSP00000442980.1, ENST00000540651.5
      Conserved Domains (1) summary
      smart00177
      Location:5179
      ARF; ARF-like small GTPases; ARF, ADP-ribosylation factor
    2. NM_001024227.1NP_001019398.1  ADP-ribosylation factor 1

      See identical proteins and their annotated locations for NP_001019398.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript.
      Source sequence(s)
      AK000620, BF337061, BG421840, BQ935470
      Consensus CDS
      CCDS1565.1
      UniProtKB/Swiss-Prot
      P84077
      UniProtKB/TrEMBL
      A0A024R3Q3
      Related
      ENSP00000440005.1, ENST00000541182.1
      Conserved Domains (1) summary
      smart00177
      Location:5179
      ARF; ARF-like small GTPases; ARF, ADP-ribosylation factor
    3. NM_001024228.2NP_001019399.1  ADP-ribosylation factor 1

      See identical proteins and their annotated locations for NP_001019399.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks a segment in the 5' UTR, as compared to variant 1.
      Source sequence(s)
      AK000620, AL136379, BF337061, BM353046, BQ949763
      Consensus CDS
      CCDS1565.1
      UniProtKB/Swiss-Prot
      P84077
      UniProtKB/TrEMBL
      A0A024R3Q3
      Conserved Domains (1) summary
      smart00177
      Location:5179
      ARF; ARF-like small GTPases; ARF, ADP-ribosylation factor
    4. NM_001658.4NP_001649.1  ADP-ribosylation factor 1

      See identical proteins and their annotated locations for NP_001649.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) has an alternate and shorter 5' UTR, as compared to variant 1.
      Source sequence(s)
      AK000620, BF337061
      Consensus CDS
      CCDS1565.1
      UniProtKB/Swiss-Prot
      P84077
      UniProtKB/TrEMBL
      A0A024R3Q3
      Related
      ENSP00000272102.5, ENST00000272102.10
      Conserved Domains (1) summary
      smart00177
      Location:5179
      ARF; ARF-like small GTPases; ARF, ADP-ribosylation factor

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

      Range
      228082708..228099212
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017001233.1XP_016856722.1  ADP-ribosylation factor 1 isoform X1

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