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    MIGA1 mitoguardin 1 [ Homo sapiens (human) ]

    Gene ID: 374986, updated on 17-Jun-2019

    Summary

    Official Symbol
    MIGA1provided by HGNC
    Official Full Name
    mitoguardin 1provided by HGNC
    Primary source
    HGNC:HGNC:24741
    See related
    Ensembl:ENSG00000180488 MIM:616773
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    FAM73A
    Expression
    Ubiquitous expression in brain (RPKM 8.8), thyroid (RPKM 7.5) and 25 other tissues See more
    Orthologs

    Genomic context

    See MIGA1 in Genome Data Viewer
    Location:
    1p31.1
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    109.20190607 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (77779624..77879540)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (78245309..78345225)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene ubiquitin specific peptidase 33 Neighboring gene actin gamma 1 pseudogene 21 Neighboring gene RNA, 5S ribosomal pseudogene 21 Neighboring gene axin interactor, dorsalization associated pseudogene Neighboring gene nuclear speckle splicing regulatory protein 1 pseudogene 1 Neighboring gene heat shock protein family E (Hsp10) member 1 pseudogene 25 Neighboring gene NEXN antisense RNA 1 Neighboring gene nexilin F-actin binding protein Neighboring gene far upstream element binding protein 1 Neighboring gene DnaJ heat shock protein family (Hsp40) member B4

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • FLJ35093, DKFZp686M07166

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein heterodimerization activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    mitochondrial fusion IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    mitochondrial fusion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    integral component of plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mitochondrial outer membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    mitoguardin 1
    Names
    family with sequence similarity 73, member A
    protein FAM73A

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001270384.1NP_001257313.1  mitoguardin 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC138392, AK296411, BC144167, BX537792, CA436207
      Consensus CDS
      CCDS72809.1
      UniProtKB/Swiss-Prot
      Q8NAN2
      UniProtKB/TrEMBL
      B4DK63, B7ZLZ8, F8W7S1
      Related
      ENSP00000393675.3, ENST00000443751.3
      Conserved Domains (1) summary
      pfam10265
      Location:59604
      DUF2217; Uncharacterized conserved protein (DUF2217)
    2. NM_001363583.1NP_001350512.1  mitoguardin 1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC114487, AC138392
      Consensus CDS
      CCDS85989.1
      Conserved Domains (1) summary
      pfam10265
      Location:27571
      Miga; Mitoguardin
    3. NM_001363584.1NP_001350513.1  mitoguardin 1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC114487, AC138392
      Consensus CDS
      CCDS85989.1
      Conserved Domains (1) summary
      pfam10265
      Location:27571
      Miga; Mitoguardin
    4. NM_001363586.1NP_001350515.1  mitoguardin 1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC114487, AC138392
      Consensus CDS
      CCDS85989.1
      Conserved Domains (1) summary
      pfam10265
      Location:27571
      Miga; Mitoguardin
    5. NM_198549.3NP_940951.1  mitoguardin 1 isoform 1

      See identical proteins and their annotated locations for NP_940951.1

      Status: VALIDATED

      Source sequence(s)
      AC138392, BX537792, CA436207
      Consensus CDS
      CCDS681.1
      UniProtKB/Swiss-Prot
      Q8NAN2
      Related
      ENSP00000359827.3, ENST00000370791.7
      Conserved Domains (1) summary
      pfam10265
      Location:59603
      DUF2217; Uncharacterized conserved protein (DUF2217)

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

      Range
      77779624..77879540
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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