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    B3GNT8 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 8 [ Homo sapiens (human) ]

    Gene ID: 374907, updated on 17-Jun-2019

    Summary

    Official Symbol
    B3GNT8provided by HGNC
    Official Full Name
    UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 8provided by HGNC
    Primary source
    HGNC:HGNC:24139
    See related
    Ensembl:ENSG00000177191 MIM:615357
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    B3GALT7; BGALT15; beta3Gn-T8
    Expression
    Broad expression in small intestine (RPKM 4.8), duodenum (RPKM 4.7) and 15 other tissues See more
    Orthologs

    Genomic context

    See B3GNT8 in Genome Data Viewer
    Location:
    19q13.2
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    109.20190607 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (41425359..41429024, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (41931264..41934635, complement)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene exosome component 5 Neighboring gene branched chain keto acid dehydrogenase E1 subunit alpha Neighboring gene VISTA enhancer hs1948 Neighboring gene distal membrane arm assembly complex 2 Neighboring gene glutamate rich 4

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    • Metabolism of proteins, organism-specific biosystem (from REACTOME)
      Metabolism of proteins, organism-specific biosystemProtein metabolism comprises the pathways of translation, post-translational modification and protein folding.
    • O-linked glycosylation, organism-specific biosystem (from REACTOME)
      O-linked glycosylation, organism-specific biosystemO-glycosylation is an important post-translational modification (PTM) required for correct functioning of many proteins (Van den Steen et al. 1998, Moremen et al. 2012). The O-glycosylation of protei...
    • O-linked glycosylation of mucins, organism-specific biosystem (from REACTOME)
      O-linked glycosylation of mucins, organism-specific biosystemMucins are a family of high molecular weight, heavily glycosylated proteins (glycoconjugates) produced by epithelial tissues in most metazoa. Mucins' key characteristic is their ability to form gels...
    • Post-translational protein modification, organism-specific biosystem (from REACTOME)
      Post-translational protein modification, organism-specific biosystemAfter translation, many newly formed proteins undergo further covalent modifications that alter their functional properties and that are essentially irreversible under physiological conditions in the...

    General gene information

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acetylgalactosaminyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    galactosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein N-acetylglucosaminyltransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    O-glycan processing TAS
    Traceable Author Statement
    more info
     
    poly-N-acetyllactosamine biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    poly-N-acetyllactosamine biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein glycosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Golgi membrane TAS
    Traceable Author Statement
    more info
     
    endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    extracellular exosome HDA PubMed 
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 8
    Names
    BGnT-8
    UDP-Gal:betaGal beta 1,3-galactosyltransferase polypeptide 7
    beta galactosyltransferase BGALT15
    beta-1,3-Gn-T8
    beta-1,3-N-acetylglucosaminyltransferase 8
    beta1,3-N-acetylglucosaminyltransferase 8

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_198540.2NP_940942.1  UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 8 precursor

      See identical proteins and their annotated locations for NP_940942.1

      Status: VALIDATED

      Source sequence(s)
      AY277592
      Consensus CDS
      CCDS12582.1
      UniProtKB/Swiss-Prot
      Q7Z7M8
      Related
      ENSP00000312700.1, ENST00000321702.2
      Conserved Domains (1) summary
      cl21608
      Location:162349
      Galactosyl_T; Galactosyltransferase

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

      Range
      41425359..41429024 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011526934.2XP_011525236.1  UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 8 isoform X1

      See identical proteins and their annotated locations for XP_011525236.1

      UniProtKB/Swiss-Prot
      Q7Z7M8
      Conserved Domains (1) summary
      cl21608
      Location:162349
      Galactosyl_T; Galactosyltransferase
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