Format

Send to:

Choose Destination
    • Showing Current items.

    ZNF568 zinc finger protein 568 [ Homo sapiens (human) ]

    Gene ID: 374900, updated on 17-Jun-2019

    Summary

    Official Symbol
    ZNF568provided by HGNC
    Official Full Name
    zinc finger protein 568provided by HGNC
    Primary source
    HGNC:HGNC:25392
    See related
    Ensembl:ENSG00000198453 MIM:617566
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ZFP568
    Expression
    Ubiquitous expression in thyroid (RPKM 1.4), ovary (RPKM 1.3) and 25 other tissues See more
    Orthologs

    Genomic context

    See ZNF568 in Genome Data Viewer
    Location:
    19q13.12
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    109.20190607 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (36916329..36997932)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (37407231..37488834)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene zinc finger protein 790 Neighboring gene zinc finger protein 345 Neighboring gene zinc finger protein 829 Neighboring gene ribosomal protein L31 pseudogene 61 Neighboring gene zinc finger protein 420 Neighboring gene uncharacterized LOC105372390 Neighboring gene Sharpr-MPRA regulatory region 11816 Neighboring gene zinc finger protein 585A

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    • Gene Expression, organism-specific biosystem (from REACTOME)
      Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
    • Generic Transcription Pathway, organism-specific biosystem (from REACTOME)
      Generic Transcription Pathway, organism-specific biosystemOVERVIEW OF TRANSCRIPTION REGULATION: Detailed studies of gene transcription regulation in a wide variety of eukaryotic systems has revealed the general principles and mechanisms by which cell- or t...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • FLJ34820, FLJ35804, DKFZp667O0524, DKFZp686B0797

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    DNA-binding transcription factor activity, RNA polymerase II-specific ISA
    Inferred from Sequence Alignment
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    transcription regulatory region sequence-specific DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    embryonic placenta morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    in utero embryonic development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of transcription by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of transcription, DNA-templated ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001204835.2NP_001191764.1  zinc finger protein 568 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
      Source sequence(s)
      AC008733, BC016334, BC131547, BX640681
      UniProtKB/Swiss-Prot
      Q3ZCX4
      UniProtKB/TrEMBL
      A2VDJ6, Q96AZ9
      Conserved Domains (5) summary
      smart00349
      Location:48102
      KRAB; krueppel associated box
      COG5048
      Location:247633
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:419439
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:4887
      KRAB; KRAB box
      pfam13465
      Location:487512
      zf-H2C2_2; Zinc-finger double domain
    2. NM_001204836.2NP_001191765.1  zinc finger protein 568 isoform 3

      See identical proteins and their annotated locations for NP_001191765.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an alternate exon in the 5' coding region and uses a downstream start codon, compared to variant 1. Variants 3 and 4 encode the same isoform (3), which has a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AC008733, AK093123, BX640681
      Consensus CDS
      CCDS56092.1
      UniProtKB/Swiss-Prot
      Q3ZCX4
      UniProtKB/TrEMBL
      Q96AZ9
      Related
      ENSP00000466901.1, ENST00000587857.5
      Conserved Domains (5) summary
      smart00349
      Location:138
      KRAB; krueppel associated box
      COG5048
      Location:184570
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:356376
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:323
      KRAB; KRAB box
      pfam13465
      Location:424449
      zf-H2C2_2; Zinc-finger double domain
    3. NM_001204837.2NP_001191766.1  zinc finger protein 568 isoform 3

      See identical proteins and their annotated locations for NP_001191766.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks alternate exons in the 5' coding region and uses a downstream start codon, compared to variant 1. Variants 3 and 4 encode the same isoform (3), which has a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AC008733, BC111777, BX640681
      Consensus CDS
      CCDS56092.1
      UniProtKB/Swiss-Prot
      Q3ZCX4
      UniProtKB/TrEMBL
      Q96AZ9
      Related
      ENSP00000394514.1, ENST00000415168.5
      Conserved Domains (5) summary
      smart00349
      Location:138
      KRAB; krueppel associated box
      COG5048
      Location:184570
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:356376
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:323
      KRAB; KRAB box
      pfam13465
      Location:424449
      zf-H2C2_2; Zinc-finger double domain
    4. NM_001204838.1NP_001191767.1  zinc finger protein 568 isoform 5

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) has multiple differences in the coding region, compared to variant 1, one of which results in a translational frameshift. The resulting protein (isoform 5) has a distinct C-terminus and is shorter than isoform 1.
      Source sequence(s)
      AC008733, AK299626, BC016334, BC108696
      Consensus CDS
      CCDS74351.1
      UniProtKB/Swiss-Prot
      Q3ZCX4
      UniProtKB/TrEMBL
      A0A087WZ84, Q96AZ9
      Related
      ENSP00000389794.1, ENST00000444991.5
      Conserved Domains (5) summary
      smart00349
      Location:137197
      KRAB; krueppel associated box
      COG5048
      Location:278621
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:537557
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:4887
      KRAB; KRAB box
      pfam13465
      Location:437462
      zf-H2C2_2; Zinc-finger double domain
    5. NM_001204839.1NP_001191768.1  zinc finger protein 568 isoform 6

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) has multiple differences in the coding region, compared to variant 1, one of which results in a translational frameshift. The resulting protein (isoform 6) has a distinct C-terminus and is shorter than isoform 1.
      Source sequence(s)
      AC008733, AK299626, BC016334
      Consensus CDS
      CCDS56093.1
      UniProtKB/Swiss-Prot
      Q3ZCX4
      UniProtKB/TrEMBL
      Q96AZ9
      Related
      ENSP00000413396.2, ENST00000455427.6
      Conserved Domains (5) summary
      smart00349
      Location:73133
      KRAB; krueppel associated box
      COG5048
      Location:224501
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:473493
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:73112
      KRAB; KRAB box
      pfam13465
      Location:373398
      zf-H2C2_2; Zinc-finger double domain
    6. NM_198539.4NP_940941.2  zinc finger protein 568 isoform 1

      See identical proteins and their annotated locations for NP_940941.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC008733, BC031218, BC111777, BX640681
      Consensus CDS
      CCDS42558.1
      UniProtKB/Swiss-Prot
      Q3ZCX4
      UniProtKB/TrEMBL
      Q96AZ9
      Related
      ENSP00000334685.7, ENST00000333987.12
      Conserved Domains (5) summary
      smart00349
      Location:48102
      KRAB; krueppel associated box
      COG5048
      Location:248634
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:420440
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:4887
      KRAB; KRAB box
      pfam13465
      Location:488513
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

      Range
      36916329..36997932
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017026773.2XP_016882262.1  zinc finger protein 568 isoform X2

      UniProtKB/Swiss-Prot
      Q3ZCX4
      Conserved Domains (5) summary
      smart00349
      Location:138
      KRAB; krueppel associated box
      COG5048
      Location:184570
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:356376
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:323
      KRAB; KRAB box
      pfam13465
      Location:424449
      zf-H2C2_2; Zinc-finger double domain
    2. XM_017026779.2XP_016882268.1  zinc finger protein 568 isoform X6

    3. XM_017026775.2XP_016882264.1  zinc finger protein 568 isoform X3

      UniProtKB/Swiss-Prot
      Q3ZCX4
      Conserved Domains (5) summary
      smart00349
      Location:73133
      KRAB; krueppel associated box
      COG5048
      Location:224501
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:473493
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:73112
      KRAB; KRAB box
      pfam13465
      Location:373398
      zf-H2C2_2; Zinc-finger double domain
    4. XM_017026774.1XP_016882263.1  zinc finger protein 568 isoform X2

      UniProtKB/Swiss-Prot
      Q3ZCX4
      Conserved Domains (5) summary
      smart00349
      Location:138
      KRAB; krueppel associated box
      COG5048
      Location:184570
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:356376
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:323
      KRAB; KRAB box
      pfam13465
      Location:424449
      zf-H2C2_2; Zinc-finger double domain
    5. XM_017026772.1XP_016882261.1  zinc finger protein 568 isoform X1

      UniProtKB/TrEMBL
      A0A087WZ84
      Conserved Domains (5) summary
      smart00349
      Location:137197
      KRAB; krueppel associated box
      COG5048
      Location:278621
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:537557
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:4887
      KRAB; KRAB box
      pfam13465
      Location:437462
      zf-H2C2_2; Zinc-finger double domain
    6. XM_017026777.1XP_016882266.1  zinc finger protein 568 isoform X4

    7. XM_017026778.1XP_016882267.1  zinc finger protein 568 isoform X5

    8. XM_017026776.1XP_016882265.1  zinc finger protein 568 isoform X4

    Support Center