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    JUND JunD proto-oncogene, AP-1 transcription factor subunit [ Homo sapiens (human) ]

    Gene ID: 3727, updated on 11-Jun-2021

    Summary

    Official Symbol
    JUNDprovided by HGNC
    Official Full Name
    JunD proto-oncogene, AP-1 transcription factor subunitprovided by HGNC
    Primary source
    HGNC:HGNC:6206
    See related
    Ensembl:ENSG00000130522 MIM:165162
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    AP-1
    Summary
    The protein encoded by this intronless gene is a member of the JUN family, and a functional component of the AP1 transcription factor complex. This protein has been proposed to protect cells from p53-dependent senescence and apoptosis. Alternative translation initiation site usage results in the production of different isoforms (PMID:12105216). [provided by RefSeq, Nov 2013]
    Orthologs
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    Genomic context

    See JUND in Genome Data Viewer
    Location:
    19p13.11
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    109.20210514 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (18279694..18281622, complement)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (18390504..18392432, complement)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene IQ motif containing N Neighboring gene Sharpr-MPRA regulatory region 4774 Neighboring gene microRNA 3188 Neighboring gene ribosomal protein L39 pseudogene 38

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Vpu vpu HIV-1 Vpu-expressing U937 monocytes coculture with LX2 stellate cells to activate release of transforming growth factor beta to culture supernatant, which correlates with increased activity of the AP-1 transcription factor PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    involved_in aging IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to calcium ion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in circadian rhythm IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in osteoblast development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of macrophage activation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of osteoblast differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in regulation of cell population proliferation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in response to light stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to lipopolysaccharide IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to mechanical stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to organic cyclic compound IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to peptide hormone IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in chromatin ISA
    Inferred from Sequence Alignment
    more info
     
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    part_of protein-DNA complex IEA
    Inferred from Electronic Annotation
    more info
     
    part_of transcription factor AP-1 complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of transcription regulator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    transcription factor jun-D
    Names
    activator protein 1
    jun D proto-oncogene

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001286968.2NP_001273897.1  transcription factor jun-D isoform deltaJunD

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes two isoforms resulting from the use of alternative in-frame translation initiation codons. The longer isoform (JunD-FL) is derived from an upstream AUG (S1 ORF, PMID:12105216), while the shorter isoform (deltaJunD) is derived from a downstream AUG (S3 ORF, PMID:12105216). This RefSeq represents the shorter isoform (deltaJunD).
      Source sequence(s)
      AK223630, AW027337, BQ130444, CB050506
      UniProtKB/Swiss-Prot
      P17535
      Conserved Domains (2) summary
      cd14696
      Location:227286
      bZIP_Jun; Basic leucine zipper (bZIP) domain of Jun proteins and similar proteins: a DNA-binding and dimerization domain
      pfam03957
      Location:1214
      Jun; Jun-like transcription factor
    2. NM_005354.6NP_005345.3  transcription factor jun-D isoform JunD-FL

      See identical proteins and their annotated locations for NP_005345.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes two isoforms resulting from the use of alternative in-frame translation initiation codons. The longer isoform (JunD-FL) is derived from an upstream AUG (S1 ORF, PMID:12105216), while the shorter isoform (deltaJunD) is derived from a downstream AUG (S3 ORF, PMID:12105216). This RefSeq represents the longer isoform (JunD-FL).
      Source sequence(s)
      AK223630, AW027337, BQ130444, CB050506
      Consensus CDS
      CCDS32959.1
      UniProtKB/Swiss-Prot
      P17535
      Related
      ENSP00000252818.3, ENST00000252818.5
      Conserved Domains (2) summary
      cd14696
      Location:270329
      bZIP_Jun; Basic leucine zipper (bZIP) domain of Jun proteins and similar proteins: a DNA-binding and dimerization domain
      pfam03957
      Location:1257
      Jun; Jun-like transcription factor

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

      Range
      18279694..18281622 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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