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    ITGAD integrin subunit alpha D [ Homo sapiens (human) ]

    Gene ID: 3681, updated on 9-Dec-2024

    Summary

    Official Symbol
    ITGADprovided by HGNC
    Official Full Name
    integrin subunit alpha Dprovided by HGNC
    Primary source
    HGNC:HGNC:6146
    See related
    Ensembl:ENSG00000156886 MIM:602453; AllianceGenome:HGNC:6146
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ADB2; CD11D
    Summary
    This gene belongs to the beta-2 integrin family of membrane glycoproteins, which are are composed of non-covalently linked alpha and beta subunits to form a heterodimer. It encodes the alpha subunit of the cell surface heterodimers and is involved in the activation and adhesion functions of leukocytes. The gene is located about 11kb downstream of the integrin subunit alpha X gene, another member of the integrin family. It is expressed in the tissue and circulating myeloid leukocytes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]
    Expression
    Biased expression in spleen (RPKM 11.2), lymph node (RPKM 2.1) and 2 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See ITGAD in Genome Data Viewer
    Location:
    16p11.2
    Exon count:
    32
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (31393335..31426505)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (31780736..31813905)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (31404656..31437826)

    Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr16:31276375-31277574 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:31282603-31283128 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:31283129-31283654 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr16:31284654-31285853 Neighboring gene integrin subunit alpha M Neighboring gene MED14-independent group 3 enhancer GRCh37_chr16:31295357-31296556 Neighboring gene ReSE screen-validated silencer GRCh37_chr16:31336636-31336863 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7417 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10761 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10762 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10763 Neighboring gene integrin subunit alpha X pseudogene Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr16:31379880-31380486 Neighboring gene integrin subunit alpha X Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:31393428-31393928 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:31393929-31394429 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:31446802-31447302 Neighboring gene ReSE screen-validated silencer GRCh37_chr16:31447884-31448054 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:31453737-31454532 Neighboring gene cytochrome c oxidase subunit 6A2 Neighboring gene zinc finger protein 843

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ39841

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables integrin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in cell adhesion mediated by integrin IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cell-cell adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cell-matrix adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in heterotypic cell-cell adhesion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in immune response NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in integrin-mediated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in cell surface IC
    Inferred by Curator
    more info
    PubMed 
    is_active_in external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of integrin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of integrin complex TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    integrin alpha-D
    Names
    CD11 antigen-like family member D
    beta-2 integrin alphaD subunit
    leukointegrin alpha D

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_050624.2 RefSeqGene

      Range
      5002..38172
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001318185.2NP_001305114.1  integrin alpha-D isoform 1 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC026471, AC093520
      UniProtKB/TrEMBL
      Q59H14
      Conserved Domains (4) summary
      smart00191
      Location:453495
      Int_alpha; Integrin alpha (beta-propellor repeats)
      cd01469
      Location:149324
      vWA_integrins_alpha_subunit; Integrins are a class of adhesion receptors that link the extracellular matrix to the cytoskeleton and cooperate with growth factor receptors to promote celll survival, cell cycle progression and cell migration. Integrins consist of an alpha and a beta ...
      pfam00357
      Location:11251139
      Integrin_alpha; Integrin alpha cytoplasmic region
      pfam08441
      Location:617958
      Integrin_alpha2; Integrin alpha
    2. NM_005353.3NP_005344.2  integrin alpha-D isoform 2 precursor

      See identical proteins and their annotated locations for NP_005344.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) contains an alternate in-frame splice site in the 5' coding region, compared to variant 1. It encodes isoform 2, which is shorter by an amino acid, compared to isoform 1.
      Source sequence(s)
      AC026471, AC093520
      Consensus CDS
      CCDS32438.1
      UniProtKB/Swiss-Prot
      Q13349, Q15575, Q15576
      UniProtKB/TrEMBL
      Q59H14
      Related
      ENSP00000373854.2, ENST00000389202.3
      Conserved Domains (4) summary
      smart00191
      Location:453509
      Int_alpha; Integrin alpha (beta-propellor repeats)
      cd01469
      Location:149324
      vWA_integrins_alpha_subunit; Integrins are a class of adhesion receptors that link the extracellular matrix to the cytoskeleton and cooperate with growth factor receptors to promote celll survival, cell cycle progression and cell migration. Integrins consist of an alpha and a beta ...
      pfam00357
      Location:11241138
      Integrin_alpha; Integrin alpha cytoplasmic region
      pfam08441
      Location:616957
      Integrin_alpha2; Integrin alpha

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

      Range
      31393335..31426505
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011545835.4XP_011544137.1  integrin alpha-D isoform X1

      UniProtKB/TrEMBL
      Q59H14
      Conserved Domains (4) summary
      smart00191
      Location:464506
      Int_alpha; Integrin alpha (beta-propellor repeats)
      cd01469
      Location:149324
      vWA_integrins_alpha_subunit; Integrins are a class of adhesion receptors that link the extracellular matrix to the cytoskeleton and cooperate with growth factor receptors to promote celll survival, cell cycle progression and cell migration. Integrins consist of an alpha and a beta ...
      pfam00357
      Location:11531167
      Integrin_alpha; Integrin alpha cytoplasmic region
      pfam08441
      Location:628933
      Integrin_alpha2; Integrin alpha
    2. XM_017023215.3XP_016878704.1  integrin alpha-D isoform X6

      UniProtKB/TrEMBL
      Q59H14
    3. XM_011545839.3XP_011544141.1  integrin alpha-D isoform X5

      UniProtKB/TrEMBL
      Q59H14
      Conserved Domains (4) summary
      smart00191
      Location:464506
      Int_alpha; Integrin alpha (beta-propellor repeats)
      cd01469
      Location:149324
      vWA_integrins_alpha_subunit; Integrins are a class of adhesion receptors that link the extracellular matrix to the cytoskeleton and cooperate with growth factor receptors to promote celll survival, cell cycle progression and cell migration. Integrins consist of an alpha and a beta ...
      pfam00357
      Location:11361150
      Integrin_alpha; Integrin alpha cytoplasmic region
      pfam08441
      Location:628969
      Integrin_alpha2; Integrin alpha
    4. XM_011545837.3XP_011544139.1  integrin alpha-D isoform X3

      UniProtKB/TrEMBL
      Q59H14
      Conserved Domains (4) summary
      smart00191
      Location:464506
      Int_alpha; Integrin alpha (beta-propellor repeats)
      cd01469
      Location:149324
      vWA_integrins_alpha_subunit; Integrins are a class of adhesion receptors that link the extracellular matrix to the cytoskeleton and cooperate with growth factor receptors to promote celll survival, cell cycle progression and cell migration. Integrins consist of an alpha and a beta ...
      pfam00357
      Location:11521166
      Integrin_alpha; Integrin alpha cytoplasmic region
      pfam08441
      Location:628932
      Integrin_alpha2; Integrin alpha
    5. XM_011545844.4XP_011544146.1  integrin alpha-D isoform X11

      UniProtKB/TrEMBL
      Q59H14
      Conserved Domains (3) summary
      smart00191
      Location:464506
      Int_alpha; Integrin alpha (beta-propellor repeats)
      cd01469
      Location:149324
      vWA_integrins_alpha_subunit; Integrins are a class of adhesion receptors that link the extracellular matrix to the cytoskeleton and cooperate with growth factor receptors to promote celll survival, cell cycle progression and cell migration. Integrins consist of an alpha and a beta ...
      pfam00357
      Location:961975
      Integrin_alpha; Integrin alpha cytoplasmic region
    6. XM_011545836.4XP_011544138.1  integrin alpha-D isoform X2

      UniProtKB/TrEMBL
      Q59H14
      Conserved Domains (4) summary
      smart00191
      Location:464520
      Int_alpha; Integrin alpha (beta-propellor repeats)
      cd01469
      Location:149324
      vWA_integrins_alpha_subunit; Integrins are a class of adhesion receptors that link the extracellular matrix to the cytoskeleton and cooperate with growth factor receptors to promote celll survival, cell cycle progression and cell migration. Integrins consist of an alpha and a beta ...
      pfam00357
      Location:11521166
      Integrin_alpha; Integrin alpha cytoplasmic region
      pfam08441
      Location:627932
      Integrin_alpha2; Integrin alpha
    7. XM_011545838.3XP_011544140.1  integrin alpha-D isoform X4

      UniProtKB/TrEMBL
      Q59H14
      Conserved Domains (4) summary
      smart00191
      Location:453495
      Int_alpha; Integrin alpha (beta-propellor repeats)
      cd01469
      Location:149324
      vWA_integrins_alpha_subunit; Integrins are a class of adhesion receptors that link the extracellular matrix to the cytoskeleton and cooperate with growth factor receptors to promote celll survival, cell cycle progression and cell migration. Integrins consist of an alpha and a beta ...
      pfam00357
      Location:11421156
      Integrin_alpha; Integrin alpha cytoplasmic region
      pfam08441
      Location:617922
      Integrin_alpha2; Integrin alpha
    8. XM_047434071.1XP_047290027.1  integrin alpha-D isoform X8

      UniProtKB/TrEMBL
      Q59H14
    9. XM_011545841.3XP_011544143.1  integrin alpha-D isoform X7

      UniProtKB/TrEMBL
      Q59H14
      Conserved Domains (4) summary
      smart00191
      Location:453509
      Int_alpha; Integrin alpha (beta-propellor repeats)
      cd01469
      Location:149324
      vWA_integrins_alpha_subunit; Integrins are a class of adhesion receptors that link the extracellular matrix to the cytoskeleton and cooperate with growth factor receptors to promote celll survival, cell cycle progression and cell migration. Integrins consist of an alpha and a beta ...
      pfam00357
      Location:11231137
      Integrin_alpha; Integrin alpha cytoplasmic region
      pfam08441
      Location:616956
      Integrin_alpha2; Integrin alpha
    10. XM_011545842.4XP_011544144.1  integrin alpha-D isoform X9

      UniProtKB/TrEMBL
      Q59H14
      Conserved Domains (4) summary
      smart00191
      Location:377419
      Int_alpha; Integrin alpha (beta-propellor repeats)
      cd01469
      Location:149324
      vWA_integrins_alpha_subunit; Integrins are a class of adhesion receptors that link the extracellular matrix to the cytoskeleton and cooperate with growth factor receptors to promote celll survival, cell cycle progression and cell migration. Integrins consist of an alpha and a beta ...
      pfam00357
      Location:10661080
      Integrin_alpha; Integrin alpha cytoplasmic region
      pfam08441
      Location:541846
      Integrin_alpha2; Integrin alpha
    11. XM_011545847.4XP_011544149.1  integrin alpha-D isoform X14

      Conserved Domains (2) summary
      cd01469
      Location:149324
      vWA_integrins_alpha_subunit; Integrins are a class of adhesion receptors that link the extracellular matrix to the cytoskeleton and cooperate with growth factor receptors to promote celll survival, cell cycle progression and cell migration. Integrins consist of an alpha and a beta ...
      pfam00357
      Location:741755
      Integrin_alpha; Integrin alpha cytoplasmic region
    12. XM_011545843.4XP_011544145.1  integrin alpha-D isoform X10

      UniProtKB/TrEMBL
      Q59H14
      Conserved Domains (3) summary
      smart00191
      Location:464506
      Int_alpha; Integrin alpha (beta-propellor repeats)
      cd01469
      Location:149324
      vWA_integrins_alpha_subunit; Integrins are a class of adhesion receptors that link the extracellular matrix to the cytoskeleton and cooperate with growth factor receptors to promote celll survival, cell cycle progression and cell migration. Integrins consist of an alpha and a beta ...
      pfam08441
      Location:628933
      Integrin_alpha2; Integrin alpha
    13. XM_011545845.4XP_011544147.1  integrin alpha-D isoform X12

      Conserved Domains (2) summary
      smart00191
      Location:464506
      Int_alpha; Integrin alpha (beta-propellor repeats)
      cd01469
      Location:149324
      vWA_integrins_alpha_subunit; Integrins are a class of adhesion receptors that link the extracellular matrix to the cytoskeleton and cooperate with growth factor receptors to promote celll survival, cell cycle progression and cell migration. Integrins consist of an alpha and a beta ...
    14. XM_011545848.4XP_011544150.1  integrin alpha-D isoform X15

      Conserved Domains (2) summary
      smart00191
      Location:464506
      Int_alpha; Integrin alpha (beta-propellor repeats)
      cd01469
      Location:149324
      vWA_integrins_alpha_subunit; Integrins are a class of adhesion receptors that link the extracellular matrix to the cytoskeleton and cooperate with growth factor receptors to promote celll survival, cell cycle progression and cell migration. Integrins consist of an alpha and a beta ...
    15. XM_011545846.4XP_011544148.1  integrin alpha-D isoform X13

      Conserved Domains (2) summary
      smart00191
      Location:464506
      Int_alpha; Integrin alpha (beta-propellor repeats)
      cd01469
      Location:149324
      vWA_integrins_alpha_subunit; Integrins are a class of adhesion receptors that link the extracellular matrix to the cytoskeleton and cooperate with growth factor receptors to promote celll survival, cell cycle progression and cell migration. Integrins consist of an alpha and a beta ...

    RNA

    1. XR_950791.3 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060940.1 Alternate T2T-CHM13v2.0

      Range
      31780736..31813905
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054380250.1XP_054236225.1  integrin alpha-D isoform X1

      UniProtKB/TrEMBL
      Q59H14
    2. XM_054380255.1XP_054236230.1  integrin alpha-D isoform X6

      UniProtKB/TrEMBL
      Q59H14
    3. XM_054380254.1XP_054236229.1  integrin alpha-D isoform X5

      UniProtKB/TrEMBL
      Q59H14
    4. XM_054380252.1XP_054236227.1  integrin alpha-D isoform X3

      UniProtKB/TrEMBL
      Q59H14
    5. XM_054380260.1XP_054236235.1  integrin alpha-D isoform X11

      UniProtKB/TrEMBL
      Q59H14
    6. XM_054380251.1XP_054236226.1  integrin alpha-D isoform X2

      UniProtKB/TrEMBL
      Q59H14
    7. XM_054380253.1XP_054236228.1  integrin alpha-D isoform X4

      UniProtKB/TrEMBL
      Q59H14
    8. XM_054380257.1XP_054236232.1  integrin alpha-D isoform X8

      UniProtKB/TrEMBL
      Q59H14
    9. XM_054380256.1XP_054236231.1  integrin alpha-D isoform X7

      UniProtKB/TrEMBL
      Q59H14
    10. XM_054380258.1XP_054236233.1  integrin alpha-D isoform X9

      UniProtKB/TrEMBL
      Q59H14
    11. XM_054380263.1XP_054236238.1  integrin alpha-D isoform X14

    12. XM_054380259.1XP_054236234.1  integrin alpha-D isoform X10

      UniProtKB/TrEMBL
      Q59H14
    13. XM_054380261.1XP_054236236.1  integrin alpha-D isoform X12

    14. XM_054380264.1XP_054236239.1  integrin alpha-D isoform X15

    15. XM_054380262.1XP_054236237.1  integrin alpha-D isoform X13

    RNA

    1. XR_008489085.1 RNA Sequence