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    Alpg alkaline phosphatase, germ cell [ Rattus norvegicus (Norway rat) ]

    Gene ID: 367308, updated on 8-Apr-2026
    Official Symbol
    Alpgprovided by RGD
    Official Full Name
    alkaline phosphatase, germ cellprovided by RGD
    Primary source
    RGD:1565100
    See related
    Ensembl:ENSRNOG00000042889 AllianceGenome:RGD:1565100
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Alppl2; RGD1565100
    Summary
    Predicted to enable alkaline phosphatase activity. Predicted to be located in myofibril. Predicted to be active in plasma membrane. Orthologous to human ALPG (alkaline phosphatase, germ cell). [provided by Alliance of Genome Resources, Jul 2025]
    Expression
    Biased expression in Heart (RPKM 5.7), Brain (RPKM 5.4) and 9 other tissues See more
    Try the new Gene page
    Try the new Transcripts and proteins table
    See Alpg in Genome Data Viewer
    Location:
    9q35
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (95187995..95205127)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (87748721..87761500)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (94164667..94184972)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene DIS3-like 3'-5' exoribonuclease 2 Neighboring gene NSA2 ribosome biogenesis factor, pseudogene 1 Neighboring gene ribosomal protein L21, pseudogene 1 Neighboring gene alkaline phosphatase, placental Neighboring gene alkaline phosphatase, intestinal

    Go to nucleotide: Graphics FASTA GenBank

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Related articles in PubMed

    1. Mutation of a single amino acid converts germ cell alkaline phosphatase to placental alkaline phosphatase. Watanabe T, et al. J Biol Chem, 1991 Nov 5. PMID 1939159
    2. Two alkaline phosphatase genes are expressed during early development in the mouse embryo. Hahnel AC, et al. Development, 1990 Oct. PMID 2133555
    3. Distinct regulatory cascades govern extraocular and pharyngeal arch muscle progenitor cell fates. Sambasivan R, et al. Dev Cell, 2009 Jun. PMID 19531352
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables alkaline phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables alkaline phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables alkaline phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    Preferred Names
    alkaline phosphatase, germ cell type-like; intestinal-type alkaline phosphatase 1-like
    Names
    alkaline phosphatase, placental-like 2

    NEW Try the new Transcript table

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      95187995..95205127
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063268168.1 → XP_063124238.1  intestinal-type alkaline phosphatase 1-like isoform X2

    2. XM_039084682.2 → XP_038940610.1  alkaline phosphatase, germ cell type-like isoform X1

      UniProtKB/TrEMBL
      F1M8U7
      Related
      ENSRNOP00000038169.7, ENSRNOT00000033487.8
      Conserved Domains (1) summary
      pfam00245
      Location:54 → 490
      Alk_phosphatase; Alkaline phosphatase

    3. XM_039084685.2 → XP_038940613.1  alkaline phosphatase, germ cell type-like isoform X3

      UniProtKB/TrEMBL
      A0A0G2JWW9
      Related
      ENSRNOP00000070046.2, ENSRNOT00000083137.3
      Conserved Domains (1) summary
      pfam00245
      Location:54 → 445
      Alk_phosphatase; Alkaline phosphatase
    Nucleotide Protein Strain
    Heading Accession and Version

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