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    INSRR insulin receptor related receptor [ Homo sapiens (human) ]

    Gene ID: 3645, updated on 17-Jun-2019

    Summary

    Official Symbol
    INSRRprovided by HGNC
    Official Full Name
    insulin receptor related receptorprovided by HGNC
    Primary source
    HGNC:HGNC:6093
    See related
    Ensembl:ENSG00000027644 MIM:147671
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    IRR
    Expression
    Biased expression in kidney (RPKM 1.2), testis (RPKM 1.1) and 5 other tissues See more
    Orthologs

    Genomic context

    See INSRR in Genome Data Viewer
    Location:
    1q23.1
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    109.20190607 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (156840063..156859117, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (156810665..156828712, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene proline rich mitotic checkpoint control factor Neighboring gene SH2 domain containing 2A Neighboring gene neurotrophic receptor tyrosine kinase 1 Neighboring gene platelet endothelial aggregation receptor 1 Neighboring gene leucine rich repeat containing 71 Neighboring gene Rho guanine nucleotide exchange factor 11 Neighboring gene microRNA 765

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    insulin receptor substrate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    insulin-activated receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    phosphatidylinositol 3-kinase binding IEA
    Inferred from Electronic Annotation
    more info
     
    transmembrane receptor protein tyrosine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    transmembrane receptor protein tyrosine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    transmembrane receptor protein tyrosine kinase activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    actin cytoskeleton reorganization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    anatomical structure development IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cellular response to alkaline pH IDA
    Inferred from Direct Assay
    more info
    PubMed 
    insulin receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    male sex determination IEA
    Inferred from Electronic Annotation
    more info
     
    peptidyl-tyrosine phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    protein autophosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    transmembrane receptor protein tyrosine kinase signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    transmembrane receptor protein tyrosine kinase signaling pathway NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    axon IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    insulin receptor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    integral component of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    integral component of plasma membrane NAS
    Non-traceable Author Statement
    more info
    PubMed 
    receptor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    receptor complex IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    insulin receptor-related protein
    Names
    IR-related receptor
    NP_055030.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_014215.3NP_055030.1  insulin receptor-related protein precursor

      See identical proteins and their annotated locations for NP_055030.1

      Status: VALIDATED

      Source sequence(s)
      AK310760, AL158169, J05046
      Consensus CDS
      CCDS1160.1
      UniProtKB/Swiss-Prot
      P14616
      Related
      ENSP00000357178.3, ENST00000368195.4
      Conserved Domains (6) summary
      cd05032
      Location:9721248
      PTKc_InsR_like; Catalytic domain of Insulin Receptor-like Protein Tyrosine Kinases
      cd00063
      Location:819908
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00064
      Location:228275
      FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.
      pfam00757
      Location:173326
      Furin-like; Furin-like cysteine rich region
      pfam01030
      Location:346460
      Recep_L_domain; Receptor L domain
      pfam07714
      Location:9791246
      Pkinase_Tyr; Protein tyrosine kinase

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

      Range
      156840063..156859117 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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