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    IL1R1 interleukin 1 receptor type 1 [ Homo sapiens (human) ]

    Gene ID: 3554, updated on 12-Aug-2018

    Summary

    Official Symbol
    IL1R1provided by HGNC
    Official Full Name
    interleukin 1 receptor type 1provided by HGNC
    Primary source
    HGNC:HGNC:5993
    See related
    Ensembl:ENSG00000115594 MIM:147810; Vega:OTTHUMG00000130783
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    P80; IL1R; IL1RA; CD121A; D2S1473; IL-1R-alpha
    Summary
    This gene encodes a cytokine receptor that belongs to the interleukin-1 receptor family. The encoded protein is a receptor for interleukin-1 alpha, interleukin-1 beta, and interleukin-1 receptor antagonist. It is an important mediator involved in many cytokine-induced immune and inflammatory responses. This gene is located in a cluster of related cytokine receptor genes on chromosome 2q12. [provided by RefSeq, Dec 2013]
    Expression
    Ubiquitous expression in gall bladder (RPKM 42.4), placenta (RPKM 40.4) and 24 other tissues See more
    Orthologs

    Genomic context

    See IL1R1 in Genome Data Viewer
    Location:
    2q11.2-q12.1
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 2 NC_000002.12 (102069638..102179874)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (102686836..102796334)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene interleukin 1 receptor type 2 Neighboring gene uncharacterized LOC107985926 Neighboring gene Sharpr-MPRA regulatory regions 1871 and 11985 Neighboring gene interleukin 1 receptor like 2 Neighboring gene family with sequence similarity 183 member D, pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Phenotypes

    NHGRI GWAS Catalog

    Description
    Common genetic variation at the IL1RL1 locus regulates IL-33/ST2 signaling.
    NHGRI GWA Catalog
    Genetic Loci Associated with Circulating Levels of Very Long-Chain Saturated Fatty Acids.
    NHGRI GWA Catalog
    Genome-wide association study to identify genetic determinants of severe asthma.
    NHGRI GWA Catalog
    Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
    NHGRI GWA Catalog
    Multiethnic meta-analysis of genome-wide association studies in >100 000 subjects identifies 23 fibrinogen-associated Loci but no strong evidence of a causal association between circulating fibrinogen and cardiovascular disease.
    NHGRI GWA Catalog

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat HIV-1 Tat upregulates the expression of IL-1RA in uninfected mononuclear cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from BioSystems

    • Amoebiasis, organism-specific biosystem (from KEGG)
      Amoebiasis, organism-specific biosystemEntamoeba histolytica, an extracellular protozoan parasite is a human pathogen that invades the intestinal epithelium. Infection occurs on ingestion of contaminated water and food. The pathogenesis o...
    • Amoebiasis, conserved biosystem (from KEGG)
      Amoebiasis, conserved biosystemEntamoeba histolytica, an extracellular protozoan parasite is a human pathogen that invades the intestinal epithelium. Infection occurs on ingestion of contaminated water and food. The pathogenesis o...
    • Apoptosis Modulation and Signaling, organism-specific biosystem (from WikiPathways)
      Apoptosis Modulation and Signaling, organism-specific biosystemApoptosis, or cell death program, can be activated by various mechanisms within the extrinsic and the intrinsic pathway. While activation of cell death receptors leads to the engagement of the extrin...
    • Cytokine Signaling in Immune system, organism-specific biosystem (from REACTOME)
      Cytokine Signaling in Immune system, organism-specific biosystemCytokines are small proteins that regulate and mediate immunity, inflammation, and hematopoiesis. They are secreted in response to immune stimuli, and usually act briefly, locally, at very low concen...
    • Cytokine-cytokine receptor interaction, organism-specific biosystem (from KEGG)
      Cytokine-cytokine receptor interaction, organism-specific biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
    • Cytokine-cytokine receptor interaction, conserved biosystem (from KEGG)
      Cytokine-cytokine receptor interaction, conserved biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
    • Fluid shear stress and atherosclerosis, organism-specific biosystem (from KEGG)
      Fluid shear stress and atherosclerosis, organism-specific biosystemShear stress represents the frictional force that the flow of blood exerts at the endothelial surface of the vessel wall and plays a central role in vascular biology and contributes to the progress o...
    • Fluid shear stress and atherosclerosis, conserved biosystem (from KEGG)
      Fluid shear stress and atherosclerosis, conserved biosystemShear stress represents the frictional force that the flow of blood exerts at the endothelial surface of the vessel wall and plays a central role in vascular biology and contributes to the progress o...
    • HTLV-I infection, organism-specific biosystem (from KEGG)
      HTLV-I infection, organism-specific biosystemHuman T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammato...
    • HTLV-I infection, conserved biosystem (from KEGG)
      HTLV-I infection, conserved biosystemHuman T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammato...
    • Hematopoietic cell lineage, organism-specific biosystem (from KEGG)
      Hematopoietic cell lineage, organism-specific biosystemBlood-cell development progresses from a hematopoietic stem cell (HSC), which can undergo either self-renewal or differentiation into a multilineage committed progenitor cell: a common lymphoid proge...
    • Hematopoietic cell lineage, conserved biosystem (from KEGG)
      Hematopoietic cell lineage, conserved biosystemBlood-cell development progresses from a hematopoietic stem cell (HSC), which can undergo either self-renewal or differentiation into a multilineage committed progenitor cell: a common lymphoid proge...
    • Hypertrophy Model, organism-specific biosystem (from WikiPathways)
      Hypertrophy Model, organism-specific biosystem
      Hypertrophy Model
    • IL-1 signaling pathway, organism-specific biosystem (from WikiPathways)
      IL-1 signaling pathway, organism-specific biosystemThe IL-1 family of cytokines currently consists of 11 members which are encoded by distinct genes and includes IL-1?, IL-1?, and the IL-1 Receptor antagonist (IL-1RA). The major role of IL-1 type cyt...
    • IL1 and megakaryocytes in obesity, organism-specific biosystem (from WikiPathways)
      IL1 and megakaryocytes in obesity, organism-specific biosystemSchematic of the effects of interleukin (IL)1-beta/IL1R1 on megakaryocyte and platelet function. A high fat diet will cause megakaryocytes to produce platelets with an increase in both inflammatory a...
    • IL1-mediated signaling events, organism-specific biosystem (from Pathway Interaction Database)
      IL1-mediated signaling events, organism-specific biosystem
      IL1-mediated signaling events
    • IL12-mediated signaling events, organism-specific biosystem (from Pathway Interaction Database)
      IL12-mediated signaling events, organism-specific biosystem
      IL12-mediated signaling events
    • Immune System, organism-specific biosystem (from REACTOME)
      Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
    • Inflammatory mediator regulation of TRP channels, organism-specific biosystem (from KEGG)
      Inflammatory mediator regulation of TRP channels, organism-specific biosystemThe TRP channels that exhibit a unique response to temperature have been given the name thermo-TRPs. Among all thermo- TRP channels, TRPV1-4, TRPM8, and TRPA1 are expressed in subsets of nociceptive...
    • Inflammatory mediator regulation of TRP channels, conserved biosystem (from KEGG)
      Inflammatory mediator regulation of TRP channels, conserved biosystemThe TRP channels that exhibit a unique response to temperature have been given the name thermo-TRPs. Among all thermo- TRP channels, TRPV1-4, TRPM8, and TRPA1 are expressed in subsets of nociceptive...
    • Integrated Pancreatic Cancer Pathway, organism-specific biosystem (from WikiPathways)
      Integrated Pancreatic Cancer Pathway, organism-specific biosystemAn integrated pathway model which displays the protein-protein interactions (PPIs) among the relevant proteins for pancreatic cancer. This pathway is a collection of different mechanistic protein pat...
    • Interleukin-1 signaling, organism-specific biosystem (from REACTOME)
      Interleukin-1 signaling, organism-specific biosystemInterleukin 1 (IL1) signals via Interleukin 1 receptor 1 (IL1R1), the only signaling-capable IL1 receptor. This is a single chain type 1 transmembrane protein comprising an extracellular ligand bindi...
    • Interleukin-10 signaling, organism-specific biosystem (from REACTOME)
      Interleukin-10 signaling, organism-specific biosystemInterleukin-10 (IL10) was originally described as a factor named cytokine synthesis inhibitory factor that inhibited T-helper (Th) 1 activation and Th1 cytokine production (Fiorentino et al. 1989). ...
    • MAPK Signaling Pathway, organism-specific biosystem (from WikiPathways)
      MAPK Signaling Pathway, organism-specific biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
    • MAPK signaling pathway, organism-specific biosystem (from KEGG)
      MAPK signaling pathway, organism-specific biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
    • MAPK signaling pathway, conserved biosystem (from KEGG)
      MAPK signaling pathway, conserved biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
    • Monoamine Transport, organism-specific biosystem (from WikiPathways)
      Monoamine Transport, organism-specific biosystem
      Monoamine Transport
    • NF-kappa B signaling pathway, organism-specific biosystem (from KEGG)
      NF-kappa B signaling pathway, organism-specific biosystemNuclear factor-kappa B (NF-kappa B) is the generic name of a family of transcription factors that function as dimers and regulate genes involved in immunity, inflammation and cell survival. There are...
    • NF-kappa B signaling pathway, conserved biosystem (from KEGG)
      NF-kappa B signaling pathway, conserved biosystemNuclear factor-kappa B (NF-kappa B) is the generic name of a family of transcription factors that function as dimers and regulate genes involved in immunity, inflammation and cell survival. There are...
    • Osteoclast differentiation, organism-specific biosystem (from KEGG)
      Osteoclast differentiation, organism-specific biosystemThe osteoclasts, multinucleared cells originating from the hematopoietic monocyte-macrophage lineage, are responsible for bone resorption. Osteoclastogenesis is mainly regulated by signaling pathways...
    • Osteoclast differentiation, conserved biosystem (from KEGG)
      Osteoclast differentiation, conserved biosystemThe osteoclasts, multinucleared cells originating from the hematopoietic monocyte-macrophage lineage, are responsible for bone resorption. Osteoclastogenesis is mainly regulated by signaling pathways...
    • Serotonin Transporter Activity, organism-specific biosystem (from WikiPathways)
      Serotonin Transporter Activity, organism-specific biosystem
      Serotonin Transporter Activity
    • Signaling by Interleukins, organism-specific biosystem (from REACTOME)
      Signaling by Interleukins, organism-specific biosystemInterleukins are low molecular weight proteins that bind to cell surface receptors and act in an autocrine and/or paracrine fashion. They were first identified as factors produced by leukocytes but a...
    • Spinal Cord Injury, organism-specific biosystem (from WikiPathways)
      Spinal Cord Injury, organism-specific biosystemThis pathway provides an overview of cell types, therapeutic targets, drugs, new proposed targets and pathways implicated in spinal cord injury. Spinal cord injury is a complex multistep process that...
    • Structural Pathway of Interleukin 1 (IL-1), organism-specific biosystem (from WikiPathways)
      Structural Pathway of Interleukin 1 (IL-1), organism-specific biosystemPathway published in http://www.ploscompbiol.org/article/info%3Adoi%2F10.1371%2Fjournal.pcbi.1003470 IL-1 signaling pathway reconstructed by combining related pathways and information from the litera...
    • Th17 cell differentiation, organism-specific biosystem (from KEGG)
      Th17 cell differentiation, organism-specific biosystemInterleukin (IL)-17-producing helper T (Th17) cells serve as a subset of CD4+ T cells involved in epithelial cell- and neutrophil mediated immune responses against extracellular microbes and in the p...
    • Th17 cell differentiation, conserved biosystem (from KEGG)
      Th17 cell differentiation, conserved biosystemInterleukin (IL)-17-producing helper T (Th17) cells serve as a subset of CD4+ T cells involved in epithelial cell- and neutrophil mediated immune responses against extracellular microbes and in the p...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    interleukin-1 binding IEA
    Inferred from Electronic Annotation
    more info
     
    interleukin-1 receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    interleukin-1, type I, activating receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    platelet-derived growth factor receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protease binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    transmembrane signaling receptor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    external side of plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    integral component of plasma membrane TAS
    Traceable Author Statement
    more info
    PubMed 
    membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    interleukin-1 receptor type 1
    Names
    CD121 antigen-like family member A
    IL-1R-1
    IL-1RT-1
    IL-1RT1
    interleukin 1 receptor alpha, type I
    interleukin-1 receptor alpha
    interleukin-1 receptor type I

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_000877.3NP_000868.1  interleukin-1 receptor type 1 isoform 1 precursor

      See identical proteins and their annotated locations for NP_000868.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) is transcribed from a downstream promoter compared to variant 2.
      Source sequence(s)
      AC007271, AL548240, BE144272, BQ021163, HY092388, M27492
      Consensus CDS
      CCDS2055.1
      UniProtKB/Swiss-Prot
      P14778
      Related
      ENSP00000386380.1, OTTHUMP00000161344, ENST00000410023.5, OTTHUMT00000253299
      Conserved Domains (4) summary
      smart00255
      Location:384540
      TIR; Toll - interleukin 1 - resistance
      smart00409
      Location:234328
      IG; Immunoglobulin
      cd05756
      Location:24113
      Ig1_IL1R_like; First immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R) and similar proteins
      cd05757
      Location:128219
      Ig2_IL1R_like; Second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R) and similar proteins
    2. NM_001288706.1NP_001275635.1  interleukin-1 receptor type 1 isoform 2 precursor

      Status: REVIEWED

      Source sequence(s)
      AK314433, AL548240, BE144272, BQ021163, DA861783, M27492
      Consensus CDS
      CCDS74547.1
      UniProtKB/Swiss-Prot
      P14778
      UniProtKB/TrEMBL
      B8ZZW4
      Related
      ENSP00000386776.1, OTTHUMP00000203891, ENST00000409929.5, OTTHUMT00000331191
      Conserved Domains (5) summary
      cd05756
      Location:24113
      Ig1_IL1R_like; First immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R) and similar proteins
      cd05757
      Location:128219
      Ig2_IL1R_like; Second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R) and similar proteins
      PHA02785
      Location:3320
      PHA02785; IL-beta-binding protein; Provisional
      smart00255
      Location:380509
      TIR; Toll - interleukin 1 - resistance
      cl11960
      Location:226327
      Ig; Immunoglobulin domain
    3. NM_001320978.1NP_001307907.1  interleukin-1 receptor type 1 isoform 1 precursor

      Status: REVIEWED

      Source sequence(s)
      AC007271, AK314433, CB240976, M27492
      Consensus CDS
      CCDS2055.1
      UniProtKB/Swiss-Prot
      P14778
      Conserved Domains (4) summary
      smart00255
      Location:384540
      TIR; Toll - interleukin 1 - resistance
      smart00409
      Location:234328
      IG; Immunoglobulin
      cd05756
      Location:24113
      Ig1_IL1R_like; First immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R) and similar proteins
      cd05757
      Location:128219
      Ig2_IL1R_like; Second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R) and similar proteins
    4. NM_001320980.1NP_001307909.1  interleukin-1 receptor type 1 isoform 1 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) is transcribed from a downstream promoter compared to variant 2.
      Source sequence(s)
      AC007271, AU136426, CB240976, DB226934, M27492
      Consensus CDS
      CCDS2055.1
      UniProtKB/Swiss-Prot
      P14778
      Conserved Domains (4) summary
      smart00255
      Location:384540
      TIR; Toll - interleukin 1 - resistance
      smart00409
      Location:234328
      IG; Immunoglobulin
      cd05756
      Location:24113
      Ig1_IL1R_like; First immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R) and similar proteins
      cd05757
      Location:128219
      Ig2_IL1R_like; Second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R) and similar proteins
    5. NM_001320981.1NP_001307910.1  interleukin-1 receptor type 1 isoform 1 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) is transcribed from a downstream promoter compared to variant 2.
      Source sequence(s)
      AC007271, BX472731, CB240976, M27492
      Consensus CDS
      CCDS2055.1
      UniProtKB/Swiss-Prot
      P14778
      Conserved Domains (4) summary
      smart00255
      Location:384540
      TIR; Toll - interleukin 1 - resistance
      smart00409
      Location:234328
      IG; Immunoglobulin
      cd05756
      Location:24113
      Ig1_IL1R_like; First immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R) and similar proteins
      cd05757
      Location:128219
      Ig2_IL1R_like; Second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R) and similar proteins
    6. NM_001320982.1NP_001307911.1  interleukin-1 receptor type 1 isoform 1 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) is transcribed from a downstream promoter compared to variant 2.
      Source sequence(s)
      AC007271, CB240976, DA333942, M27492
      Consensus CDS
      CCDS2055.1
      UniProtKB/Swiss-Prot
      P14778
      Conserved Domains (4) summary
      smart00255
      Location:384540
      TIR; Toll - interleukin 1 - resistance
      smart00409
      Location:234328
      IG; Immunoglobulin
      cd05756
      Location:24113
      Ig1_IL1R_like; First immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R) and similar proteins
      cd05757
      Location:128219
      Ig2_IL1R_like; Second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R) and similar proteins
    7. NM_001320983.1NP_001307912.1  interleukin-1 receptor type 1 isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: The 5' UTR variation has not been determined for this transcript.
      Source sequence(s)
      AC007271, CB240976, CD013913, CD014140, M27492, X16896
      UniProtKB/Swiss-Prot
      P14778
      Conserved Domains (4) summary
      cd05757
      Location:175
      Ig2_IL1R_like; Second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R) and similar proteins
      smart00255
      Location:240396
      TIR; Toll - interleukin 1 - resistance
      smart00410
      Location:90184
      IG_like; Immunoglobulin like
      cl11960
      Location:82183
      Ig; Immunoglobulin domain
    8. NM_001320984.1NP_001307913.1  interleukin-1 receptor type 1 isoform 4

      Status: REVIEWED

      Description
      Transcript Variant: The 5' UTR variation has not been determined for this transcript.
      Source sequence(s)
      AC007271, CB240976, CD013912, M27492, X16896
      UniProtKB/Swiss-Prot
      P14778
      Conserved Domains (3) summary
      smart00255
      Location:201357
      TIR; Toll - interleukin 1 - resistance
      smart00410
      Location:51145
      IG_like; Immunoglobulin like
      cl11960
      Location:136
      Ig; Immunoglobulin domain
    9. NM_001320985.1NP_001307914.1  interleukin-1 receptor type 1 isoform 5

      Status: REVIEWED

      Description
      Transcript Variant: The 5' UTR variation has not been determined for this transcript.
      Source sequence(s)
      AC007271, CB240976, CD013913, M27492, X16896
      UniProtKB/Swiss-Prot
      P14778
      Conserved Domains (2) summary
      smart00255
      Location:149305
      TIR; Toll - interleukin 1 - resistance
      smart00410
      Location:193
      IG_like; Immunoglobulin like
    10. NM_001320986.1NP_001307915.1  interleukin-1 receptor type 1 isoform 6 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (10) is transcribed from a downstream promoter compared to variant 2.
      Source sequence(s)
      AU136426, CA421991, DB226934
      Related
      ENSP00000386555.1, OTTHUMP00000203890, ENST00000409589.5, OTTHUMT00000331190
      Conserved Domains (3) summary
      cd05756
      Location:24113
      Ig1_IL1R_like; First immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R) and similar proteins
      smart00410
      Location:43103
      IG_like; Immunoglobulin like
      cl11960
      Location:128162
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p12 Primary Assembly

      Range
      102069638..102179874
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011511117.1XP_011509419.1  interleukin-1 receptor type 1 isoform X1

      See identical proteins and their annotated locations for XP_011509419.1

      UniProtKB/Swiss-Prot
      P14778
      Conserved Domains (4) summary
      smart00255
      Location:384540
      TIR; Toll - interleukin 1 - resistance
      smart00409
      Location:234328
      IG; Immunoglobulin
      cd05756
      Location:24113
      Ig1_IL1R_like; First immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R) and similar proteins
      cd05757
      Location:128219
      Ig2_IL1R_like; Second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R) and similar proteins
    2. XM_011511115.2XP_011509417.1  interleukin-1 receptor type 1 isoform X1

      See identical proteins and their annotated locations for XP_011509417.1

      UniProtKB/Swiss-Prot
      P14778
      Conserved Domains (4) summary
      smart00255
      Location:384540
      TIR; Toll - interleukin 1 - resistance
      smart00409
      Location:234328
      IG; Immunoglobulin
      cd05756
      Location:24113
      Ig1_IL1R_like; First immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R) and similar proteins
      cd05757
      Location:128219
      Ig2_IL1R_like; Second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R) and similar proteins
    3. XM_011511116.1XP_011509418.1  interleukin-1 receptor type 1 isoform X1

      See identical proteins and their annotated locations for XP_011509418.1

      UniProtKB/Swiss-Prot
      P14778
      Conserved Domains (4) summary
      smart00255
      Location:384540
      TIR; Toll - interleukin 1 - resistance
      smart00409
      Location:234328
      IG; Immunoglobulin
      cd05756
      Location:24113
      Ig1_IL1R_like; First immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R) and similar proteins
      cd05757
      Location:128219
      Ig2_IL1R_like; Second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R) and similar proteins
    4. XM_017003989.1XP_016859478.1  interleukin-1 receptor type 1 isoform X1

      UniProtKB/Swiss-Prot
      P14778
      Conserved Domains (4) summary
      smart00255
      Location:384540
      TIR; Toll - interleukin 1 - resistance
      smart00409
      Location:234328
      IG; Immunoglobulin
      cd05756
      Location:24113
      Ig1_IL1R_like; First immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R) and similar proteins
      cd05757
      Location:128219
      Ig2_IL1R_like; Second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R) and similar proteins
    5. XM_005263930.4XP_005263987.1  interleukin-1 receptor type 1 isoform X1

      See identical proteins and their annotated locations for XP_005263987.1

      UniProtKB/Swiss-Prot
      P14778
      Conserved Domains (4) summary
      smart00255
      Location:384540
      TIR; Toll - interleukin 1 - resistance
      smart00409
      Location:234328
      IG; Immunoglobulin
      cd05756
      Location:24113
      Ig1_IL1R_like; First immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R) and similar proteins
      cd05757
      Location:128219
      Ig2_IL1R_like; Second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R) and similar proteins
    6. XM_005263934.4XP_005263991.1  interleukin-1 receptor type 1 isoform X1

      See identical proteins and their annotated locations for XP_005263991.1

      UniProtKB/Swiss-Prot
      P14778
      Conserved Domains (4) summary
      smart00255
      Location:384540
      TIR; Toll - interleukin 1 - resistance
      smart00409
      Location:234328
      IG; Immunoglobulin
      cd05756
      Location:24113
      Ig1_IL1R_like; First immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R) and similar proteins
      cd05757
      Location:128219
      Ig2_IL1R_like; Second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R) and similar proteins
    7. XM_011511118.2XP_011509420.1  interleukin-1 receptor type 1 isoform X1

      See identical proteins and their annotated locations for XP_011509420.1

      UniProtKB/Swiss-Prot
      P14778
      Conserved Domains (4) summary
      smart00255
      Location:384540
      TIR; Toll - interleukin 1 - resistance
      smart00409
      Location:234328
      IG; Immunoglobulin
      cd05756
      Location:24113
      Ig1_IL1R_like; First immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R) and similar proteins
      cd05757
      Location:128219
      Ig2_IL1R_like; Second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R) and similar proteins
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