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    LCE2C late cornified envelope 2C [ Homo sapiens (human) ]

    Gene ID: 353140, updated on 17-Jun-2024

    Summary

    Official Symbol
    LCE2Cprovided by HGNC
    Official Full Name
    late cornified envelope 2Cprovided by HGNC
    Primary source
    HGNC:HGNC:29460
    See related
    Ensembl:ENSG00000187180 MIM:612611; AllianceGenome:HGNC:29460
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    LEP11
    Summary
    Enables identical protein binding activity. Predicted to be involved in keratinization. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Restricted expression toward skin (RPKM 72.0) See more
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    Genomic context

    See LCE2C in Genome Data Viewer
    Location:
    1q21.3
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (152675279..152676569)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (151811823..151813113)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (152647755..152649045)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 302 Neighboring gene late cornified envelope pseudogene 3 Neighboring gene late cornified envelope 2D Neighboring gene late cornified envelope 2B Neighboring gene late cornified envelope 2A

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in keratinization IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    late cornified envelope protein 2C
    Names
    late envelope protein 11

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_178429.5NP_848516.1  late cornified envelope protein 2C

      See identical proteins and their annotated locations for NP_848516.1

      Status: VALIDATED

      Source sequence(s)
      AL139247
      Consensus CDS
      CCDS1019.1
      UniProtKB/Swiss-Prot
      Q5TA81
      Related
      ENSP00000357772.1, ENST00000368783.2
      Conserved Domains (1) summary
      pfam14672
      Location:60110
      LCE; Late cornified envelope

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      152675279..152676569
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      151811823..151813113
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)